Abstract
Syndromes of coronary heart disease with angina pectoris were analyzed to provide guidance for clinical practice and to improve accuracy of traditional Chinese medicine (TCM) diagnoses and efficacy of TCM treatment. A total of 860 cases with coronary heart disease with angina pectoris were selected from TCM Clinical Research Information Sharing System for TCM clinics and research. Syndromes were automatically extracted with the cluster method and were analyzed to provide objective evidence for clinical studies. Final syndrome classifications were recognized and confirmed by clinical experts. Popular syndromes included Qi and blood deficiency, blood stasis and obstruction collaterals, liver depression and spleen deficiency, and Qi stagnation and blood stasis. Syndromes Qi and blood deficiency and blood stasis and obstruction collaterals accounted for 28.61% of total syndromes, whereas liver depression and spleen deficiency and Qi stagnation and blood stasis accounted for 26.44%. The main syndrome elements comprised Qi deficiency, blood deficiency, blood stasis, and Qi stagnation.
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References
Zhou J, Ji W, Lu H, Tang M, Li J, Nie Y. Study of the pattern characteristics and diversity of stable and unstable angina pectoris based on cluster analysis. World J Inter Tradit West Med (Shi Jie Zhong Xi Yi Jie He Za Zhi) 2012; 7(1): 43–45 (in Chinese)
Zhou JX, Tang M, Li J. Analysis of Chinese syndrome features and combination laws of 2029 patients with coronary heart disease angina. Chin J Integr Tradit West Med (Zhongguo Zhong Xi Yi Jie He Za Zhi) 2011; 31(6): 753–755 (in Chinese)
Zhou JX, Yu GY, Nie YY, Tang M, Jie L. Chinese medicine syndrome characteristic based on clustering analysis of 2029 cases of angina pectoris of coronary heart disease. Chin J Inform Tradit Chin Med (Zhongguo Zhong Yi Yao Xin Xi Za Zhi) 2011; 18(8): 19–21 (in Chinese)
Li DT, Li J, Wang J, Zhang MZ, Wei LB, Jiang RX. Study of TCM syndromes diagnostic criterion of coronary heart disease. J Shandong Univ Tradit Chin Med (Shandong Zhong Yi Yao Da Xue Xue Bao) 2011; 35(2): 117–120 (in Chinese)
Nelson LC, Ryan LJ. The treatment of cardiovascular disease with acupuncture. Med Acup 2014; 26(6): 333–340
Liu W, Xiong X, Yang X, Chu F, Liu H. The effect of Chinese herbal medicine gualouxiebaibanxia decoction for the treatment of angina pectoris: a systematic review. Evid Based Complement Alternat Med 2016; 2016: 8565907
Chen J, Lu P, Zuo X, Shi W, Zhao H, Luo L, Yi J, Zheng C, Yang Y, Wang W. Clinical data mining of phenotypic network in angina pectoris of coronary heart disease. Evid Based Complement Alternat Med 2012; 2012: 546230
Huang J, Tang X, Ye F, He J, Kong X. Clinical therapeutic effects of aspirin in combination with Fufang Danshen Diwan, a traditional Chinese medicine formula on coronary heart disease: a systematic review and meta-analysis. Cell Physiol Biochem 2016; 39(5): 1955–1963
Li P, Ma H. Efficacy of Qingxin Huatan therapy in regulating cardiac autonomic nerve function in patients with chronic stable angina: study protocol for a randomized controlled trial. Clin Trials Degener Dis 2016; 1(2): 51–57
Li S, Xu H. Integrative western and Chinese medicine on coronary heart disease: where is the orientation. Evid Based Complement Alternat Med 2013; 2013: 459264
Yang T, Hu K. Study on distribution rules of TCM four diagnostic information based on complex network in patients with CHD angina pectoris. International Conference on Bioinformatics and Biomedicine, December 15–18, 2016. Shenzhen, China. 1385–1388
Hao PP, Jiang F, Chen YG, Yang J, Zhang K, Zhang MX, Zhang C, Zhao YX, Zhang Y. Traditional Chinese medication for cardiovascular disease. Nat Rev Cardiol 2015; 12(2): 115–122
Zhao Y, He L, Xie Q, Li G, Liu B, Wang J, Zhang X, Zhang X, Luo L, Li K, Jing X. A novel classification method for syndrome differentiation of patients with AIDS. Evid Based Complement Alternat Med 2015; 2015: 936290
Zhao YF, He LY, Liu BY, Li J, Li FY, Huo RL, Jing XH. Syndrome classification based on manifold ranking for viral hepatitis. Chin J Integr Med 2014; 20(5): 394–399
Zhao Y, Xie Q, He L, Liu B, Li K, Zhang X, Bai W. Comparison analysis of data mining models applied to clinical research in traditional Chinese medicine. J Tradit Chin Med 2014; 34(5): 627–634
Gu Z, Qi X, Zhai X, Lang Q, Lu J, Ma C, Liu L, Yue X. Study on TCM syndrome differentiation of primary liver cancer based on the analysis of latent structural model. Evid Based Complement Alternat Med 2014; 2014: 761565
Li G, Yan S, You M, Sun S, Ou A. Intelligent ZHENG classification of hypertension depending on ML-kNN and feature fusion. Evid Based Complement Alternat Med 2012; 2012: 837245
Soni J, Ansari U, Sharma D, Soni S. Predictive data mining for medical diagnosis: an overview of heart disease prediction. Int J Comput Appl 2014; 8(17): 43–48
Wu D, Lin J, Wang P, Wang Y, Lu F. Analysis on composition principles of prescriptions for erectile dysfunction by using traditional Chinese medicine inheritance system. Chin Tradit Patent Med (Zhong Cheng Yao) 2016; 38(4): 755–759 (in Chinese)
Li Y, Zheng G, Liu L. Treatment rules of Sinomenium acutum by text mining. World Chin Med (Shi Jie Zhong Yi Yao) 2015; 10(6): 823–827 (in Chinese)
Liu B, Zhou X, Zhang R, Wang Y, Xie Q, Guo Y, Zhang X, Zhou X, He L, Zhang L, Song G, Zhang Y, Zhang H, Li B, Zhao S. Basic requirements of TCM Electronic Medical Record System in Medical Treatment and Clinical Scientific Research Information Sharing System. Chin Digital Med (Zhongguo Shu Zi Yi Xue) 2012; 7(10): 57–60 (in Chinese)
Acknowledgements
This study was supported by National Natural Science Foundation of China (Nos. 81674101 and 81202858), National Key Technology Support Program (No. 2012BAI25B02), Self-selected subject of China Academy of Chinese Medical Sciences (Nos. ZZ05003, ZZ03090, and Z0217), Beijing Key Laboratory of Advanced Information Science Network Technology (No. XDXX1306), and Autonomous Grant from Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences (No. Z254).
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Zhao, Y., Yu, X., Cao, X. et al. Cluster analysis for syndromes of real-world coronary heart disease with angina pectoris. Front. Med. 12, 566–571 (2018). https://doi.org/10.1007/s11684-017-0556-1
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DOI: https://doi.org/10.1007/s11684-017-0556-1