Frontiers of Medicine

, Volume 11, Issue 2, pp 169–177 | Cite as

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis of infectious diseases

  • Changlin Cao
  • Jingxian Gu
  • Jingyao Zhang


Sensitive and useful biomarkers for the diagnosis and prognosis of infectious diseases have been widely developed. An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which is a cell surface receptor expressed on monocytes/macrophages and neutrophils. TREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway. This pathway is triggered by the interaction of TREM-1 with ligands or stimulation by bacterial lipopolysaccharide. Consequently, pro-inflammatory cytokines and chemokines are secreted. Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluids and well-known biomarker for infectious diseases. sTREM-1 level can be potentially used for the early diagnosis and prognosis prediction of some infectious diseases, including infectious pleural effusion, lung infections, sepsis, bacterial meningitis, viral infections (e.g., Crimean Congo hemorrhagic fever and dengue fever), fungal infections (e.g., Aspergillus infection), and burn-related infections. sTREM-1 is a more sensitive and specific biomarker than traditional indices, such as C-reactive protein and procalcitonin levels, for these infectious diseases. Therefore, sTREM-1 is a feasible biomarker for the targeted therapy and rapid and early diagnosis of infectious diseases.


soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis biomarker 


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This study was supported by the National Natural Science Foundation of China (No. 81601672) and the Fundamental Research Funds for the Central Universities (No.1191320114). We are indebted to all individuals who participated in or helped with this research project.


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of Pulmonary MedicineChenzhou No.1 People’s HospitalChenzhouChina
  2. 2.Department of Hepatobiliary Surgerythe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina
  3. 3.Department of SICUthe First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

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