Frontiers of Medicine

, Volume 11, Issue 1, pp 68–73 | Cite as

Improved control of hypertension following laparoscopic fundoplication for gastroesophageal reflux disease

  • Zhiwei Hu
  • Meiping Chen
  • Jimin Wu
  • Qing Song
  • Chao Yan
  • Xing Du
  • Zhonggao Wang
Research Article


This study aims to determine whether successful laparoscopic fundoplication for gastroesophageal reflux disease (GERD) can improve the control of hypertension. We conducted an observational study of GERD patients with hypertension. The esophageal and gastroesophageal symptoms of these patients were successfully treated with laparoscopic fundoplication, as measured by the reduced GERD symptoms and proton pump inhibitor consumption. A hypertension control scale was used to classify the use of antihypertensive medications and the quality of blood pressure control before and after anti-reflux surgery.Wilcoxon signed-ranks test was used for the statistical analyses. Seventy GERD patients were included in the analysis and followed up for a mean period of 3.5 ± 1.4 years. Prior to surgery, all participating patients were taking at least one class of antihypertensive medication, and 56 patients (80%) had intermittently high blood pressure. After surgery, the mean number of antihypertensive medication classes per patient was significantly reduced from 1.61 ± 0.77 pre-procedure to 1.27 ± 0.88 post-procedure (P < 0.001). The blood pressure of 48 of the 56 cases (86%) with preoperative intermittent high blood pressure returned to normal post procedure. A total of 50 patients (71%) recorded improvements on the hypertension control scale, with the overall mean score decreasing from 3.1 ± 1.0 preprocedure to 1.4 ± 1.0 post-procedure (P < 0.001). Therefore, successful laparoscopic fundoplication may result in better blood pressure control in some hypertensive GERD patients. This result suggests a possible connection between gastroesophageal reflux and hypertension.


gastroesophageal reflux disease hypertension blood pressure laparoscopic fundoplication 


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This study is supported by Beijing Municipal Science and Technology Commission (No. Z141107002514109).


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Zhiwei Hu
    • 1
  • Meiping Chen
    • 1
  • Jimin Wu
    • 1
  • Qing Song
    • 1
  • Chao Yan
    • 2
  • Xing Du
    • 2
  • Zhonggao Wang
    • 1
    • 2
  1. 1.Department of Gastroesophageal Reflux DiseasePLA Rocket Force General HospitalBeijingChina
  2. 2.Department of Vascular Surgery, Xuanwu HospitalCapital Medical UniversityBeijingChina

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