Frontiers of Medicine

, Volume 10, Issue 4, pp 522–526 | Cite as

Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated with herpes zoster: a case report

Case Report


Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient’s symptoms were alleviated. Furthermore, he recovered from hematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.


autograft bone marrow stem cells ulcerative colitis cell therapy 


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Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Hang Xiang
    • 1
  • Xiaomei Zhang
    • 1
  • Chao Yang
    • 2
  • Wenhuan Xu
    • 1
  • Xin Ge
    • 3
  • Rong Zhang
    • 2
  • Ya Qiu
    • 1
  • Wanjun Sun
    • 2
  • Fan Li
    • 1
  • Tianyuan Xiang
    • 4
  • Haixu Chen
    • 1
  • Zheng Wang
    • 5
  • Qiang Zeng
    • 1
  1. 1.Institute of Health Management, Institute of Geriatrics, Beijing Key Laboratory of Normal Aging and Geriatrics, Department of Gerontal GastroenterologyChinese PLA General HospitalBeijingChina
  2. 2.Department of Blood Transfusion, Department of HematologyThe General Hospital of the PLA Rocket ForceBeijingChina
  3. 3.Galactophore Department of the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  4. 4.Geriatrics Institute of Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijingChina
  5. 5.Department of Biotherapy of PLA 455 HospitalShanghaiChina

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