Abstract
This paper reviews the present theories and empirical research of autisms’ cognitive research and mirror systems and introduces a new hypothesis about the causes of autism spectrum disorders (ASD): autistic mirror neuron dysfunction hypothesis. ASD subjects show obvious lack of the activation of the mirror system during the task of observation or emotional cognition. It is significant to investigate the mirror system for revealing the causes of autism and it is also helpful for developing new ways to diagnose or treat this disorder.
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Baron-Cohen S, Leslie A M, Frith U. Does the autistic child have a ‘theory of mind’? Cognition, 1985, 21(1): 37–46
Brunet E, Sarfati Y, Hardy-Baylé M C, Decety J. Abnormalities of brain function during a nonverbal theory of mind task in schizophrenia. Neuropsychologia, 2003, 41(12): 1574–1582
Sabbagh M A. Understanding orbit frontal contributions to theory-of-mind reasoning: Implications for autism. Brain Cogn, 2004, 55(1): 209–219
Williams J H, Whiten A, Suddendorf T, Perrett D I. Imitation, mirror neurons and autism. Neurosci Biobehav Rev, 2001, 25(4): 287–295
Gallese V, Fadiga L, Fogassi L, Rizzolatti G. Action recognition in the premotor cortex. Brain, 1996, 119(Pt2): 593–609
Rizzolatti G, Fadiga L, Matelli M, Bettinardi V, Paulesu E, Perani D, Fazio F. Localization of grasp representation in humans by PET: 1. Observation versus execution. Exp Brain Res, 1996, 111(2): 246–252
Grafton S T, Arbib MA, Fadiga L, Rizzolatti G. Localization of grasp representation in humans by positron emission tomography: 2. Observation compared with imagination. Exp Brain Res, 1996, 112(1): 103–111
Kohler E, Keysers C, Umiltà M A, Fogassi L, Gallese V, Rizzolatti G. Hearing sounds, understanding actions: action representation in mirror neurons. Science, 2002, 297(5582): 846–848
Umiltà M A, Kohler E, Gallese V, Fogassi L, Fadlga L, Keysers C, Rizzolatti G. I know what you are doing: a neurophysiological study. Neuron, 2001, 31(1): 155–165
Wicker B, Keysers C, Plailly J, Royet J, Gallese V, Rizzolatti G. Both of us disgusted in my insula: the common neural basis of seeing and feeling disgust. Neuron, 2003, 40(3): 655–664
Nishitani N, Avikainen S, Hari R. Abnormal imitation-related cortical activation sequences in Asperger’s syndrome. Ann Neurol, 2004, 55(4): 558–562
Oberman L M, Hubbard E M, McCleery J P, Altschuler E L, Ramachandran V S, Pineda J A. EEG evidence for mirror neuron dysfunction in autism spectrum disorders. Brain Res Cogn Brain Res, 2005, 24(2): 190–198
Williams J H G, Waiter G D, Gilchrist A, Perrett D I, Murray A D, Whiten A. Neural mechanisms of imitation and ‘mirror neuron’ functioning in autistic spectrum disorder. Neuropsychologia, 2006, 44(4): 610–621
Dapretto M, Davies M S, Pfeifer J H, Scott A A, Sigman M, Bookheimer S Y, Iacoboni M. Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders. Nat Neurosci, 2006, 9(1): 28–30
Gallese V, Goldman A. Mirror neurons and the simulation theory of mind-reading. Trends Cogn Sci, 1998, 2(12): 493–501
Rizzolatti G, Fogassi L, Gallese V. Neurophysiological mechanisms underlying the understanding and imitation of action. Nat Rev Neurosci, 2001, 2(9): 661–670
Muthukumaraswamy S D, Johnson B W. Primary motor cortex activation during action observation revealed by wavelet analysis of the EEG. Clin Neurophysiol, 2004, 115(8): 1760–1766
Pfurtscheller G, Neuper C, Andrew C, Edlinger G. Foot and hand area mu rhythms. Int J Psychophysiol, 1997, 26(1): 121–135
Iacoboni M, Dapretto M. The mirror neuron system and the consequences of its dysfunction. Nat Rev Neurosci, 2006, 7(12): 942–951
Gallese V. Intentional attunement: a neurophysiological perspective on social acognition and its disruption in autism. Brain Res, 2006, 1079(1): 15–24
Catmur C, Walsh V, Heyes C. Sensorimotor learning configures the human mirror system. Curr Biol, 2007, 17(17): 1527–1531
Ramachandran V S, Oberman L M. Broken mirrors: a theory of autism. Sci Am, 2006, 295(5): 62–69
Southgate V, Hamilton A F. Unbroken mirrors: challenging a theory of Autism. Trends Cogn Sci, 2008, 12(6): 225–229
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Chen, W., Zhang, J. & Ding, J. Mirror system based therapy for autism spectrum disorders. Front. Med. China 2, 344–347 (2008). https://doi.org/10.1007/s11684-008-0065-3
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DOI: https://doi.org/10.1007/s11684-008-0065-3