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Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin

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Abstract

The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats. A rat model with pulmonary fibrosis was established by intratracheal injection of bleomycin. On days 14, 28 and 45, the contents of laminin, collagen I and collagen III in lung tissue homogenate in the model group, the sham operated group, the Feixian group and the prednisone group were measured. The contents of laminin and collagen I and III were decreased significantly by the Feixian Recipe. Feixian Recipe has a significant therapeutic effect on bleomycin-induced pulmonary fibrosis in rats.

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Authors and Affiliations

  1. Department of Respiratory Diseases, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, 100078, China

    Xiaomei Zhang

  2. Department of Internal Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China

    Liangduo Jiang & Wei Zhang

  3. Department of Traditional Chinese Medicine, Beijing Royal Integrative Medicine Hospital, Beijing, 102209, China

    Jianjun Wu

  4. Department of Pathology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China

    Xiangfeng Lu

Authors
  1. Xiaomei Zhang
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  2. Liangduo Jiang
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  3. Wei Zhang
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  4. Jianjun Wu
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  5. Xiangfeng Lu
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Corresponding author

Correspondence to Xiaomei Zhang.

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Translated from Journal of Beijing University of Traditional Chinese Medicine, 2007, 30(9): 608–610 [译自: 北京中医药大学学报]

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Zhang, X., Jiang, L., Zhang, W. et al. Effect of Feixian Recipe on laminin, collagen I and III in rats with pulmonary fibrosis induced by bleomycin. Front. Med. China 2, 314–316 (2008). https://doi.org/10.1007/s11684-008-0060-8

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  • DOI: https://doi.org/10.1007/s11684-008-0060-8

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