Skip to main content
SpringerLink
Log in

Clinical manifestations and outcomes in severe ulcerative colitis

  • Research Article
  • Published:
Frontiers of Medicine in China Aims and scope Submit manuscript

Abstract

In order to evaluate the clinical manifestations and outcomes of severe ulcerative colitis (UC), we retrospectively reviewed 41 patients with severe UC from 144 consecutively hospitalized UC cases from 1988 to 2004. Data recorded included onset, symptoms, signs, laboratory results, endoscopic, radiologic and pathologic findings, the clinical treatment process and follow-up. Of these severe cases, 92.7% (38/41) had pancolitis. Clinically, 36.9% (15/41) were categorized as first onset type, 36.9% (15/41) were chronic persistent and 26.8% (11/41) were chronic recurrent. Steroids played a main role in the remission of severe UC (61.0%). Thirty-one cases (75.6%) were relieved by drug therapy. Seven cases (17.1%) progressed to the need for operation. An early age of onset, pancolitis, low hemoglobin and serum albumin levels, and the need for intravenous steroids tended to be associated with the need for surgery. In conclusion, most of the severe UC patients respond well to drug therapy, but for individuals who are unresponsive to drug therapy, or for those depending on steroids, after a reasonable duration of treatment, the necessity for surgery should be considered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Travis S P. Review article: The management of mild to severe acute ulcerative colitis. Aliment Pharmacol Ther, 2004, 20(Suppl 4): 88–92

    Article  PubMed  Google Scholar 

  2. Aspenvall L, Aadland E. Severe ulcerative colitis. Tidsskr Nor Laegeforen, 1990, 110(12): 1520–1522

    CAS  PubMed  Google Scholar 

  3. Chinese Society of Gastroenterology. Suggestive guidline of diagnosis and treatment for inflammatory bowel disease. Chin J Dig, 2001, 21(4): 236–239 (in Chinese)

    Google Scholar 

  4. Kumar S, Ghoshal U C, Aggarwal R, Saraswat V A, Choudhuri G. Severe ulcerative colitis: Prospective study of parameters determineing outcome. J Gastroenterol Hepatol, 2004, 19(11):1247–12525.

    Article  PubMed  Google Scholar 

  5. Veloso F T. Review article: Skin complications associated with inflamematory bowel disease. Aliment Pharmacol Ther, 2004, 20(Suppl 4): 50–53

    Article  Google Scholar 

  6. Benazzato L, D’Inca R, Grigoletto F, Perissinotto E, Medici V, Angriman I, Sturniolo G C. Prognosis of severe attacks in ulcerative colitiss: Effect of intensive medical treatment. Dig Liver Dis, 2004, 36(7): 461–466

    Article  CAS  PubMed  Google Scholar 

  7. Gionchetti P, Rizzelo F, Habal F, Morselli C, Amadini C, Romagnoli R, Campieri M. Standard treatment of ulcerative colitis. Dig Dis, 2003, 21(2): 157–167

    Article  PubMed  Google Scholar 

  8. Han Y. The evaluation of clinical treatment for maintenance remission of inflammatory bowel disease. Eval Anal Drug-use Hosp Chin, 2004, 4(6): 338–340 (in Chinese)

    Google Scholar 

  9. Xu C T, Meng S Y, Pan B R. Drug therapy for ulcerative colitis. World J Gastroenterol, 2004, 10(16): 2311–2317

    CAS  PubMed  Google Scholar 

  10. Ghirardi M, Fabio F D, Mariani P P, Nascimbeni R, Salerni B. Surgery in severe ulcerative colitis: Our experience. Ann Ital Chir, 2003, 74(5): 543–546

    CAS  PubMed  Google Scholar 

  11. Reinisch W, Dejaco C, Knoflach P, Petritsch W, Vogelsang H, Tilg H. Immunosupressive therapy for inflamematory bowel disease: Consensus by the Austrian working group on IBD. Z Gastroenterol, 2004, 42(9): 1033–1045

    Article  CAS  PubMed  Google Scholar 

  12. Danalioglu A, Kaymakoglu S, Mungan Z, Karaca C, Demir K, Durakoglu Z, Besisik F, Boztas G, Cakaloglu Y, Okyen A. Cyclosporin for severe ulcerative colitis attacks. Hepatogastroenterology, 2003, 50(Suppl 2): ccxcviii–ccc

    PubMed  Google Scholar 

  13. Bebb J R, Scott B B. How effective are the usual treatments for ulcerative colitis? Aliment Pharmacol Ther, 2004, 20(2): 143–149

    Article  CAS  PubMed  Google Scholar 

  14. Ho G T, Mowat C, Goddard C J, Fennell J M, Shah N B, Prescott R J, Satsangi J. Predicting the outcome of severe ulcerative colitis: Development of a novel risk score to aid early selection of patients for second-line medical therapy or surgery. Aliment Pharmacol Ther, 2004, 19(10): 1079–1087

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Gastroenterology, Peking University Third Hospital, Beijing, 100083, China

    Yang Xuesong MD, Yao Wei MD, Liu Wenbin MD, Li Jun MD & Lu Yumin MD

Authors
  1. Yang Xuesong MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yao Wei MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Liu Wenbin MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Li Jun MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lu Yumin MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yang Xuesong MD.

Additional information

Translated from Chinese Journal of Digestion, 2006, 26(5): 291–294 [译自: 中华消化杂志]

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yang, X., Yao, W., Liu, W. et al. Clinical manifestations and outcomes in severe ulcerative colitis. Front. Med. China 1, 192–195 (2007). https://doi.org/10.1007/s11684-007-0036-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11684-007-0036-0

Keywords

Search

Navigation