Skip to main content
SpringerLink
Log in

Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

  • Research Article
  • Published:
Frontiers of Medicine in China Aims and scope Submit manuscript

Abstract

The overall diagnostic capabilities and utility of frequency-doubling technology (FDT) in patients with primary glaucoma, which was diagnosed by standard automated perimetry (SAP) and/or optic disc appearance as the gold standard, were assessed. A comprehensive electric retrieval in MEDLINE, EMBASE, Cochrane Library, BIOSIS, Previews, HMIC, IPA, OVID, CNKI, CBMdisc, VIP information, CMCC, CCPD, SSreader, 21dmedia and manual retrieval in related textbooks, journals, congress articles and their references at home and abroad were performed to identify relevant articles in English or Chinese. The corresponding references were retrieved by means of electric retrieval and manual retrieval from different databases or materials. Criteria for inclusion or exclusion were established according to validity criteria for diagnostic studies published by the Cochrane Methods Group on Screening and Diagnostic Tests. The quality of the included articles was then assessed and characteristics were extracted. Statistical analysis was performed with Meta Test version 0.6 software to test the heterogeneity of the included articles. The appropriate effects model was selected to calculate pooled weighted sensitivity and specificity. Summary receiver operating characteristic (SROC) curve was drawn and the area under the curve (AUC) was calculated. Finally, sensitivity analysis was performed. Twenty-one studies out of 206 retrieved articles were included, with a total of 3172 patients. The reported sensitivity of FDT ranged from 0.51 to 1.00, and specificity from 0.58 to 1.00. The pooled weighted sensitivity and specificity of FDT with 95% confidence intervals (95% CI) after correction for standard error were 0.86 (0.80–0.90) and 0.87 (0.81–0.91), respectively. The AUC of SROC was 93.01%. Sensitivity analysis demonstrated no disproportionate influences of individual studies. The included articles are of good quality and FDT can be a highly efficient diagnostic test for primary glaucom a based on Meta-analysis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kelly D H. Diffusion model of linear flicker responses. J Opt Soc Am, 1969, 59(12): 665–670

    Article  Google Scholar 

  2. Muskens R P, Heeg G P, Jansonius N M. An evaluation of algorithms designed to classify the results from frequency doubling perimetry. Ophthalmic Physiol Opt, 2004, 24(6): 498–503

    Article  PubMed  Google Scholar 

  3. Stoutenbeek R, Heeg G P, Jansonius N M. Frequency doubling perimetry screening mode compared to the full-threshold mode. Ophthalmic Physiol Opt, 2004, 24(6): 493–497

    Article  PubMed  Google Scholar 

  4. Chandrasekhar G, Kunjam V, Rao V S, Nutheti R. Humphrey visual field and frequency doubling perimetry in the diagnosis of early glaucoma. Indian J Ophthalmol, 2003, 51(1): 35–38

    CAS  PubMed  Google Scholar 

  5. Bayer A U, Erb C. Short wavelength automated perimetry, frequency doubling technology perimetry, and pattern electroretinography for prediction of progressive glaucomatous standard visual field defects. Ophthalmology, 2002, 109(5): 1009–1017

    Article  PubMed  Google Scholar 

  6. Thomas R, Bhat S, Muliyil J P, Parikh R, George R. Frequency doubling perimetry in glaucoma. J Glaucoma, 2002, 11(5): 46–50

    Article  PubMed  Google Scholar 

  7. Bowd C, Zangwill L M, Berry C C, Blumenthal E Z, Vasile C, Sanchez-Galeana C, Bosworth C F, Sample P A, Weinreb R N. Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function. Invest Ophthalmol Vis Sci, 2001, 42(9): 1993–2003

    CAS  PubMed  Google Scholar 

  8. Andrada M T, Bemaldo De Quiros P, Villegas R S, Anton A. Diagnostic accuracy of frequency doubling perimetry. Arch Soc Esp Oftalmol, 2001, 76(12): 711–718

    CAS  PubMed  Google Scholar 

  9. Thomas D, Thomas R, Muliyil J P, George R. Role of frequency doubling perimetry in detecting neuro-ophthalmic visual field defects. Am J Ophthalmol, 2001, 131(6): 734–741

    Article  CAS  PubMed  Google Scholar 

  10. Casson R, James B, Rubinstein A, Ali H. Clinical comparison of frequency doubling technology perimetry and Humphrey perimetry. Br J Ophthalmol, 2001, 85(3): 360–362

    Article  CAS  PubMed  Google Scholar 

  11. Sample P A, Bosworth C F, Blumenthal E Z, Girkin C, Weinreb R N. Visual function-specific perimetry for indirect comparison of different ganglion cell populations in glaucoma. Invest Ophthalmol Vis Sci, 2000, 41(7): 1783–1790

    CAS  PubMed  Google Scholar 

  12. Trible J R, Schultz R O, Robinson J C, Rothe T L. Accuracy of glaucoma detection with frequency-doubling perimetry. Am J Ophthalmol, 2000, 129(6): 740–745

    Article  CAS  PubMed  Google Scholar 

  13. Fabre K, Michiels I, Zeyen T. The sensitivity and specificity of TOP, FDP and GDx in screening for early glaucoma. Bull Soc Belge Ophthalmol, 2000, 275: 17–23

    CAS  Google Scholar 

  14. Cello K E, Nelson-Quigg J M, Johnson C A. Frequency doubling technology perimetry for detection of glaucomatous visual field loss. Am J Ophthalmol, 2000, 129(3): 314–322

    Article  CAS  PubMed  Google Scholar 

  15. Yamada N, Chen PP, Mills RP, Leen M M, Lieberman M F, Stamper R L, Stanford D C. Screening for glaucoma with frequency-doubling technology and Damato campimetry. Arch Ophthalmol, 1999, 117(11): 1479–1484

    Article  CAS  PubMed  Google Scholar 

  16. Wu T X, Liu G J. Introduction of Bayes Library and Meta-analysis of diagnostic trials. Chin JEBM, 2002, 2: 182–186

    Google Scholar 

  17. Liu G J, Wu T X. Introduction of SROC method-Meta-analysis of diagnostic trials. Chin J EBM, 2003, 1: 41–44

    Google Scholar 

  18. Moses L E, Shapiro D, Littenberg B. Combining independent studies of a diagnostic test into a summary ROC curve: data analytic approaches and some additional considerations. Stat Med, 1993, 12(14): 1293–1316

    Article  CAS  PubMed  Google Scholar 

  19. Deeks J J. Systematic reviews in healthcare: Systematic reviews of evaluations of diagnostic and screening tests. BMJ, 2001, 323(7305): 157–162

    Article  CAS  PubMed  Google Scholar 

  20. Wall M, Neahring R K, Woodward K R. Sensitivity and specificity of frequency doubling perimetry in neuro-ophthalmic disorders: a comparison with conventional automated perimetry. Invest Ophthalmol Vis Sci, 2002, 43(4): 1277–1283

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China

    Liu Ting MS & He Xiangge MD PhD

Authors
  1. Liu Ting MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. He Xiangge MD PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to He Xiangge MD PhD.

Additional information

Translated from Chin J Ophthalmol, 2006, 42(5): 403–408 [译自: 中华眼科杂志]

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liu, T., He, X. Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma. Front. Med. China 1, 109–114 (2007). https://doi.org/10.1007/s11684-007-0021-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11684-007-0021-7

Keywords

Search

Navigation