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Hippocampal subfield volumes in mild cognitive impairment and alzheimer’s disease: a systematic review and meta-analysis

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Abstract

The hippocampus is a complex structure that consists of several subfields with distinct and specialized functions. Although numerous studies have been performed to explore hippocampal atrophy at the sub-regional level in mild cognitive impairment (MCI) and Alzheimer’s disease (AD), the results have been inconsistent especially for whether and which subfields can be served as the most potential biomarkers in MCI and AD. Herein, we used a meta-analytic approach to synthesize the extant literatures on hippocampal subfields in MCI and AD through PubMed, Web of Science, and Embase (PROSPERO CRD42021257586). As a result, a total of twenty studies using Freesurfer 5 and Freesurfer 6 were included in this investigation. These studies revealed that at the sub-regional level, hippocampal subfield volume reductions in MCI and AD were not restricted to specific subfields, and subiculum and presubiculum had the largest z-scores across most comparisons. However, none of the subfield performed much better in discriminating MCI and HC, AD and MCI, AD and HC as compared to whole hippocampus volume. These results suggested that we should explore the changes in the hippocampal subfields in subtypes of MCI or even at an earlier stage, that is subjective cognitive impairment.

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Data Availability

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Funding

This work was supported by National Natural Science Foundation of China (No. 82305388, 62006220 and 62001462), National Key R&D Program of China (2019YFC1712200), International standards research on clinical research and service of Acupuncture-Moxibustion (2019YFC1712205), Shenzhen Science and Technology Research Program (No. JCYJ20180507182441903 and JCYJ20200109114816594), and Special Innovation Project of the Guangdong Provincial Department of Education (2021WQNCX068).

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  1. Jinhuan Zhang and Linlin, Xie contributed equally.

Authors and Affiliations

  1. The fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, 518033, China

    Jinhuan Zhang, Linlin Xie, Changjiang Cheng & Haibo Yu

  2. Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China

    Jinhuan Zhang, Xiaodong Zhang, Haoyu Wang & Jinping Xu

  3. Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, China

    Jinhuan Zhang, Linlin Xie, Yongfeng Liu & Haibo Yu

  4. College of Creative Design, Shenzhen Technology University, Shenzhen, China

    Jingting Hu

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  1. Jinhuan Zhang
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Contributions

Y.H.B, and X.J.P designed the whole study. Z.J.H, Z.X.D, and W.H.Y analyzed the data, Z.J.H wrote the manuscript. L.Y.F, H.J.T and X.L.L searched and selected the studies. C.C.J participated in the discussion. All authors read and approved the final manuscript.

Corresponding authors

Correspondence to Haibo Yu or Jinping Xu.

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Ethical approval and consent to participate

Not applicable. This meta-analysis uses data from already published papers. The data collection procedures for the participants’ data employed here were approved by the local Institutional Review Boards of the respective data acquisition sites.

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Informed consent was obtained from all participants included in the study.

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Zhang, J., Xie, L., Cheng, C. et al. Hippocampal subfield volumes in mild cognitive impairment and alzheimer’s disease: a systematic review and meta-analysis. Brain Imaging and Behavior 17, 778–793 (2023). https://doi.org/10.1007/s11682-023-00804-3

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