Abstract
Children with attention-deficit/hyperactivity disorder (ADHD) demonstrate reduced response inhibition, increased response time variability, and atypical frontal lobe white matter microstructure with emerging evidence of sex differences. This study aims to examine whether frontal lobe white matter microstructure is differentially impacted in ADHD by sex and whether this relates to Go/No-Go (GNG) task performance. Diffusion tensor imaging (DTI) from 187 children (8–12 years), including ADHD (n = 94) and typically developing controls (TD; n = 93). Participants completed three GNG tasks with varying cognitive demands and incentives (standard, cognitive, and motivational). Fractional anisotropy (FA) was examined as an index of white matter microstructure within bilateral frontal lobe regions of interest. Children with ADHD showed reduced FA in primary motor (M1) and supplementary motor area (SMA) regardless of sex. Sex-based dissociation for the effect of diagnosis was observed in medial orbitofrontal cortex (mOFC), with higher FA in girls with ADHD and lower FA in boys with ADHD. Both diagnosis and sex contributed to performance on measures of response inhibition and reaction time (RT) variability, with all children with ADHD demonstrating poorer performance on all GNG tasks, but boys with ADHD demonstrating more impulsivity on standard and motivational behavioral paradigms compared to girls with ADHD. Analyses revealed associations between reduced FA in M1, SMA, and mOFC and increased response inhibition and RT variability with some sex-based differences. These findings provide novel insights regarding the brain basis of ADHD and associated impairments in response inhibition and RT variability, and contribute to our understanding of sexual dimorphic behavioral outcomes.
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The datasets generated during and/or analyzed during the current study are available from the authors on reasonable request.
Code Availability
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References
Andersson, J. L. R., & Sotiropoulos, S. N. (2016). An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage, 125, 1063–1078. https://doi.org/10.1016/j.neuroimage.2015.10.019.
Andersson, J. L. R., Skare, S., & Ashburner, J. (2003). How to correct susceptibility distortions in spin-echo echo-planar images: Application to diffusion tensor imaging. Neuroimage, 20(2), 870–888. https://doi.org/10.1016/S1053-8119(03)00336-7.
Andersson, J. L. R., Graham, M. S., Zsoldos, E., & Sotiropoulos, S. N. (2016). Incorporating outlier detection and replacement into a non-parametric framework for movement and distortion correction of diffusion MR images. Neuroimage, 141, 556–572. https://doi.org/10.1016/j.neuroimage.2016.06.058.
Aoki, Y., Cortese, S., & Castellanos, F. X. (2017). Research Review: Diffusion tensor imaging studies of attention-deficit/hyperactivity disorder: meta‐analyses and reflections on head motion. Journal of Child Psychology and Psychiatry, 59(3), 193–202. https://doi.org/10.1111/jcpp.12778.
Asato, M. R., Terwilliger, R., Woo, J., & Luna, B. (2010). White matter development in adolescence: A DTI study. Cerebral Cortex, 20(9), 2122–2131.
Bari, A., & Robbins, T. W. (2013). Inhibition and impulsivity: Behavioral and neural basis of response control. Progress in Neurobiology, 108(2013), 44–79. https://doi.org/10.1016/j.pneurobio.2013.06.005.
Barkley, R. A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121(1), 65.
Behrens, T. E. J., Woolrich, M. W., Jenkinson, M., Johansen-Berg, H., Nunes, R. G., Clare, S., Matthews, P. M., Brady, J. M., & Smith, S. M. (2003). Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magnetic Resonance in Medicine, 50(5), 1077–1088. https://doi.org/10.1002/mrm.10609.
Behrens, T. E. J., Berg, J., Jbabdi, H., Rushworth, S.,, M. F. S., & Woolrich, M. W. (2007). Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? Neuroimage, 34(1), 144–155. https://doi.org/10.1016/j.neuroimage.2006.09.018.
Bitsko, R. H., Claussen, A. H., Lichstein, J., Black, L. I., Jones, S. E., Danielson, M. L., & Meyer, L. N. (2022). Mental health surveillance among children—United States, 2013–2019. MMWR Supplements, 71(2), 1–42. https://doi.org/10.15585/mmwr.su7102a1.
Bush, G., Valera, E. M., & Seidman, L. J. (2005). Functional neuroimaging of attention-deficit/hyperactivity disorder: A review and suggested future directions. Biological Psychiatry, 57(11), 1273–1284. https://doi.org/10.1016/j.biopsych.2005.01.034.
Castellanos, F. X., Sonuga-Barke, E. J., Scheres, A., Di Martino, A., Hyde, C., & Walters, J. R. (2005). Varieties of attention-deficit/hyperactivity disorder-related intra-individual variability. Biological Psychiatry, 57(11), 1416–1423. https://doi.org/10.1016/j.biopsych.2004.12.00.
Castellanos, F. X., Sonuga-Barke, E. J., Milham, M. P., & Tannock, R. (2006). Characterizing cognition in ADHD: Beyond executive dysfunction. Trends in Cognitive Sciences, 10(3), 117–123.
Cole, W. R., Mostofsky, S. H., Larson, J. G., Denckla, M. B., & Mahone, E. M. (2008). Age-related changes in motor subtle signs among girls and boys with ADHD. Neurology, 71(19), 1514–1520.
Conners, C. K. (Conners’ Rating Scales - Revised. Published online 1997).
Conners, C. K. Conners, Third Edition (Conners-3). Published online 2008.
Cubillo, A., Halari, R., Smith, A., Taylor, E., & Rubia, K. (2012). A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with attention deficit hyperactivity disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior, 48(2), 194–215. https://doi.org/10.1016/j.cortex.2011.04.007.
Danielson, M. L., Holbrook, J. R., Bitsko, R. H., Newsome, K., Charania, S. N., McCord, R. F., & Blumberg, S. J. (2022). State-level estimates of the prevalence of parent-reported ADHD diagnosis and treatment among US children and adolescents, 2016 to 2019. Journal of Attention Disorders, 26(13), 1685–1697. https://doi.org/10.1177/10870547221099961.
De Bellis, M. D., Keshavan, M. S., Beers, S. R., Hall, J., Frustaci, K., Masalehdan, A., & Boring, A. M. (2001). Sex differences in brain maturation during childhood and adolescence. Cerebral Cortex, 11(6), 552–557.
DeRonda, A., Zhao, Y., Seymour, K. E., Mostofsky, S. H., & Rosch, K. S. (2021). Distinct patterns of impaired cognitive control among boys and girls with ADHD Across Development. Research on Child and Adolescent Psychopathology, 49(7), 835–848.
Dirlikov, B., Rosch, K. S., Crocetti, D., Denckla, M. B., Mahone, E. M., & Mostofsky, S. H. (2015). Distinct frontal lobe morphology in girls and boys with ADHD. NeuroImage: Clinical, 7, 222–229. https://doi.org/10.1016/j.nicl.2014.12.010.
DuPaul, G. J., Reid, R., Anastopoulos, A. D., Lambert, M. C., Watkins, M. W., & Power, T. J. (2016). Parent and teacher ratings of attention-deficit/hyperactivity disorder symptoms: Factor structure and normative data. Psychological Assessment, 28(2), 214. https://doi.org/10.1037/pas0000166.
Gaddis, A., Rosch, K. S., Dirlikov, B., Crocetti, D., MacNeil, L., Barber, A. D., & Mostofsky, S. H. (2015). Motor overflow in children with attention-deficit/hyperactivity disorder is associated with decreased extent of neural activation in the motor cortex. Psychiatry Research: Neuroimaging, 233(3), 488–495.
Gaub, M., & Carlson, C. L. (1997). Gender differences in ADHD: A meta-analysis and critical review. Journal of the American Academy of Child & Adolescent Psychiatry, 36(8), 1036–1045.
Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., & Rapoport, J. L. (1999). Brain development during childhood and adolescence: A longitudinal MRI study. Nature Neuroscience, 2(10), 861–863.
Gilbert, D. L., Isaacs, K. M., Augusta, M., Macneil, L. K., & Mostofsky, S. H. (2011). Motor cortex inhibition: A marker of ADHD behavior and motor development in children. Neurology, 76(7), 615–621.
Gumus, K., Keating, B., Poser, B. A., Armstrong, B., Chang, L., Maclaren, J., & Ernst, T. (2014). Prevention of motion-induced signal loss in diffusion‐weighted echo‐planar imaging by dynamic restoration of gradient moments. Magnetic Resonance in Medicine, 71(6), 2006–2013. https://doi.org/10.1002/mrm.24857.
Haber, S. N. (2003). The primate basal ganglia: Parallel and integrative networks. Journal of Chemical Neuroanatomy, 26(4), 317–330.
Haber, S. N. (2016). Corticostriatal circuitry. Dialogues in Clinical Neuroscience, 18(1), 7–21.
Hasson, R., & Fine, J. G. (2012). Gender differences among children with ADHD on continuous performance tests: A meta-analytic review. Journal of Attention Disorders, 16(3), 190–198.
Jacobson, L. A., Peterson, D. J., Rosch, K. S., Crocetti, D., Mori, S., & Mostofsky, S. H. (2015). Sex-based dissociation of white matter microstructure in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 54(11), 938–946.
Karalunas, S. L., Geurts, H. M., Konrad, K., Bender, S., & Nigg, J. T. (2014). Annual research review: Reaction time variability in ADHD and autism spectrum disorders: Measurement and mechanisms of a proposed trans-diagnostic phenotype. Journal of Child Psychology and Psychiatry, 55(6), 685–710. https://doi.org/10.1111/jcpp.12217.
Kaso, A., & Ernst, T. (2021). Motion-insensitive diffusion imaging of the brain using optical tracking and dynamic sequence updates. Magnetic Resonance in Medicine, 86(2), 926–934. https://doi.org/10.1002/mrm.28747.
Kaufman, J., Birmaher, B., Brent, D., Rao, U. M. A., Flynn, C., Moreci, P., & Ryan, N. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 36(7), 980–988. https://doi.org/10.1097/00004583-199707000-00021.
Kofler, M. J., Rapport, M. D., Sarver, D. E., Raiker, J. S., Orban, S. A., Friedman, L. M., & Kolomeyer, E. G. (2013). Reaction time variability in ADHD: A meta-analytic review of 319 studies. Clinical Psychology Review, 33(6), 795–811. https://doi.org/10.1016/j.cpr.2013.06.001.
Kofler, M. J., Irwin, L. N., Soto, E. F., Groves, N. B., Harmon, S. L., & Sarver, D. E. (2019). Executive functioning heterogeneity in pediatric ADHD. Journal of Abnormal Child Psychology, 47(2), 273–286. https://doi.org/10.1007/s10802-018-0438-2.
Konrad, K., & Eickhoff, S. B. (2010). Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Human Brain Mapping, 31(6), 904–916.
Lacouture, Y., & Cousineau, D. (2008). How to use MATLAB to fit the ex-gaussian and other probability functions to a distribution of response times. Tutorials in Quantitative Methods for Psychology, 4(1), 35–45.
Lenroot, R. K., & Giedd, J. N. (2006). Brain development in children and adolescents: Insights from anatomical magnetic resonance imaging. Neuroscience & Biobehavioral Reviews, 30(6), 718–729.
Lenroot, R. K., Gogtay, N., Greenstein, D. K., Wells, E. M., Wallace, G. L., Clasen, L. S., & Giedd, J. N. (2007). Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage, 36(4), 1065–1073.
Leth-Steensen, C., Elbaz, Z. K., & Douglas, V. I. (2000). Mean response times, variability, and skew in the responding of ADHD children: A response time distributional approach. Acta Psychologica, 104(2), 167–190. https://doi.org/10.1016/S0001-6918(00)00019-6.
Lijffijt, M., Kenemans, J. L., Verbaten, M. N., & van Engeland, H. (2005). A meta-analytic review of stopping performance in attention-deficit/hyperactivity disorder: Deficient inhibitory motor control? Journal of Abnormal Psychology, 114(2), 216. https://doi.org/10.1037/0021-843X.114.2.216.
Loyer Carbonneau, M., Demers, M., Bigras, M., & Guay, M. C. (2021). Meta-analysis of sex differences in ADHD symptoms and associated cognitive deficits. Journal of Attention Disorders, 25(12), 1640–1656.
MacNeil, L. K., Xavier, P., Garvey, M. A., Gilbert, D. L., Ranta, M. E., Denckla, M. B., & Mostofsky, S. H. (2011). Quantifying excessive mirror overflow in children with attention-deficit/hyperactivity disorder. Neurology, 76(7), 622–628.
Mahone, E. M., Ranta, M. E., Crocetti, D., O’Brien, J., Kaufmann, W. E., Denckla, M. B., & Mostofsky, S. H. (2011). Comprehensive examination of frontal regions in boys and girls with attention-deficit/hyperactivity disorder. Journal of the International Neuropsychological Society, 17(6), 1047–1057.
Mostofsky, S. H., Cooper, K. L., Kates, W. R., Denckla, M. B., & Kaufmann, W. E. (2002). Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder. Biological Psychiatry, 52(8), 785–794.
Mostofsky, S. H., Newschaffer, C. J., & Denckla, M. B. (2003). Overflow movements predict impaired response inhibition in children with ADHD. Perceptual and Motor Skills, 97(3 Pt 2), 1315–1331.
Mostofsky, S. H., Rimrodt, S. L., Schafer, J. G., Boyce, A., Goldberg, M. C., Pekar, J. J., & Denckla, M. B. (2006). Atypical motor and sensory cortex activation in attention-deficit/hyperactivity disorder: A functional magnetic resonance imaging study of simple sequential finger tapping. Biological Psychiatry, 59(1), 48–56.
Nigg, J. T. (2005). Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: The state of the field and salient challenges for the coming decade. Biological Psychiatry, 57(11), 1424–1435.
Nigg, J. T., Karalunas, S. L., Feczko, E., & Fair, D. A. (2020). Toward a revised nosology for attention-deficit/hyperactivity disorder heterogeneity. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(8), 726–737. https://doi.org/10.1016/j.bpsc.2020.02.005.
Nikolaidis, A., He, X., Pekar, J., Rosch, K., & Mostofsky, S. H. (2022). Frontal corticostriatal functional connectivity reveals task positive and negative network dysregulation in relation to ADHD, sex, and inhibitory control. Developmental Cognitive Neuroscience, 54, 101101. https://doi.org/10.1016/j.dcn.2022.101101.
O’Brien, J. W., Dowell, L. R., Mostofsky, S. H., Denckla, M. B., & Mahone, E. M. (2010). Neuropsychological profile of executive function in girls with attention-deficit/hyperactivity disorder. Archives of Clinical Neuropsychology, 25(7), 656–670.
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012). Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage, 59(3), 2142–2154.
Ranta, M. E., Crocetti, D., Clauss, J. A., Kraut, M. A., Mostofsky, S. H., & Kaufmann, W. E. (2009). Manual MRI parcellation of the frontal lobe. Psychiatry Research: Neuroimaging, 172(2), 147–154.
Ranta, M. E., Chen, M., Crocetti, D., Prince, J. L., Subramaniam, K., Fischl, B., & Mostofsky, S. H. (2014). Automated MRI parcellation of the frontal lobe. Human Brain Mapping, 35(5), 2009–2026.
Rapport, M. D., Alderson, R. M., Kofler, M. J., Sarver, D. E., Bolden, J., & Sims, V. (2008). Working memory deficits in boys with attention-deficit/hyperactivity disorder (ADHD): The contribution of central executive and subsystem processes. Journal of Abnormal Child Psychology, 36(6), 825–837. https://doi.org/10.1007/s10802-010-9387-0.
Reich, W. (2000). Diagnostic interview for children and adolescents (DICA). Journal of the American Academy of Child & Adolescent Psychiatry, 39(1), 59–66. https://doi.org/10.1097/00004583-200001000-00017.
Roalf, D. R., Quarmley, M., Elliott, M. A., Satterthwaite, T. D., Vandekar, S. N., Ruparel, K., Gennatas, E. D., Calkins, M. E., Moore, T. M., Hopson, R., Prabhakaran, K., Jackson, C. T., Verma, R., Hakonarson, H., Gur, R. C., & Gur, R. E. (2016). The impact of quality assurance assessment on diffusion tensor imaging outcomes in a large-scale population-based cohort. Neuroimage, 125, 903–919. https://doi.org/10.1016/j.neuroimage.2015.10.068.
Rosch, K. S., & Mostofsky, S. H. (2016). Increased delay discounting on a novel real-time task among girls, but not boys, with ADHD. Journal of the International Neuropsychological Society, 22(1), 12–23. https://doi.org/10.1017/S1355617715001071.
Rosch, K. S., Dirlikov, B., & Mostofsky, S. H. (2015). Reduced intrasubject variability with reinforcement in boys, but not girls, with ADHD: Associations with prefrontal anatomy. Biological Psychology, 110, 12–23. https://doi.org/10.1016/j.biopsycho.2015.06.010.
Rosch, K. S., Crocetti, D., Hirabayashi, K., Denckla, M. B., Mostofsky, S. H., & Mahone, E. M. (2018a). Reduced subcortical volumes among preschool-age girls and boys with ADHD. Psychiatry Research: Neuroimaging, 271, 67–74. https://doi.org/10.1016/j.pscychresns.2017.10.013.
Rosch, K. S., Mostofsky, S. H., & Nebel, M. B. (2018b). ADHD-related sex differences in fronto-subcortical intrinsic functional connectivity and associations with delay discounting. Journal of Neurodevelopmental Disorders, 10(1), 1–14.
Rucklidge, J. J. (2010). Gender differences in attention-deficit/hyperactivity disorder. Psychiatric Clinics, 33(2), 357–373.
Sergeant, J. A. (2005). Modeling attention-deficit/hyperactivity disorder: A critical appraisal of the cognitive-energetic model. Biological Psychiatry, 57(11), 1248–1255. https://doi.org/10.1016/j.biopsych.2004.09.010.
Seymour, K. E., Mostofsky, S. H., & Rosch, K. S. (2016). Cognitive load differentially impacts response control in girls and boys with ADHD. Journal of Abnormal Child Psychology, 44(1), 141–154. https://doi.org/10.1007/s10802-015-9976-z.
Seymour, K. E., Tang, X., Crocetti, D., Mostofsky, S. H., Miller, M. I., & Rosch, K. S. (2017). Anomalous subcortical morphology in boys, but not girls, with ADHD compared to typically developing controls and correlates with emotion dysregulation. Psychiatry Research: Neuroimaging, 261, 20–28. https://doi.org/10.1016/j.pscychresns.2017.01.002.
Shaw, P., Stringaris, A., Nigg, J., & Leibenluft, E. (2014). Emotion dysregulation in attention deficit hyperactivity disorder. American Journal of Psychiatry, 171(3), 276–293.
Shiels Rosch, K., Dirlikov, B., & Mostofsky, S. H. (2013). Increased intrasubject variability in boys with ADHD across tests of motor and cognitive control. Journal of Abnormal Child Psychology, 41(3), 485–495.
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., Niazy, R. K., Saunders, J., Vickers, J., Zhang, Y., De Stefano, N., Brady, J. M., & Matthews, P. M. (2004). Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage, 23, S208–S219. https://doi.org/10.1016/j.neuroimage.2004.07.051.
Sonuga-Barke, E. J., Bitsakou, P., & Thompson, M. (2010). Beyond the dual pathway model: Evidence for the dissociation of timing, inhibitory, and delay-related impairments in attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49(4), 345–355.
Spencer, T. J., Brown, A., Seidman, L. J., Valera, E. M., Makris, N., Lomedico, A., & Biederman, J. (2013). Effect of psychostimulants on brain structure and function in ADHD: A qualitative literature review of magnetic resonance imaging-based neuroimaging studies. The Journal of Clinical Psychiatry, 74(9), 902–912.
Stevens, M. C., Pearlson, G. D., Calhoun, V. D., & Bessette, K. L. (2017). Functional neuroimaging evidence for distinct neurobiological pathways in Attention-Deficit/Hyperactivity disorder. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3(8), 675–685.
Tamm, L., Narad, M. E., Antonini, T. N., O’Brien, K. M., Hawk, L. W., & Epstein, J. N. (2012). Reaction time variability in ADHD: A review. Neurotherapeutics, 9(3), 500–508. https://doi.org/10.1007/s13311-012-0138-5.
Tao, R., Fletcher, P. T., Gerber, S., & Whitaker, R. T. (2009). A Variational Image-Based Approach to the Correction of Susceptibility Artifacts in the Alignment of Diffusion Weighted and Structural MRI. Information Processing in Medical Imaging: Proceedings of the … Conference, 21, 664–675.
Townsend, L., Kobak, K., Kearney, C., Milham, M., Andreotti, C., Escalera, J., & Kaufman, J. (2020). Development of three web-based computerized versions of the kiddie schedule for affective disorders and schizophrenia child psychiatric diagnostic interview: Preliminary validity data. Journal of the American Academy of Child & Adolescent Psychiatry, 59(2), 309–325. https://doi.org/10.1016/j.jaac.2019.05.009.
Vaurio, R. G., Simmonds, D. J., & Mostofsky, S. H. (2009). Increased intra-individual reaction time variability in attention-deficit/hyperactivity disorder across response inhibition tasks with different cognitive demands. Neuropsychologia, 47(12), 2389–2396. https://doi.org/10.1016/j.neuropsychologia.2009.01.022.
Wechsler, D. (2002). Wechsler individual achievement test, second edition. Psychological Corp.
Wechsler, D. (2003). Wechsler Intelligence Scale for Children, Fourth edition. Psychological Corp.
Wechsler, D. (2009). Wechsler individual achievement test, third edition. Psychological Corp.
Wechsler, D. (2014). Wechsler Intelligence Scale for Children, Fifth Edition. NCS Pearson.
Willcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biological Psychiatry, 57(11), 1336–1346.
Wodka, E. L., Mahone, M., Blankner, E., Larson, J. G. G., Fotedar, J. C., Denckla, S., M. B., & Mostofsky, S. H. (2007). Evidence that response inhibition is a primary deficit in ADHD. Journal of Clinical and Experimental Neuropsychology, 29(4), 345–356. https://doi.org/10.1080/13803390600678046.
Wu, M., Chang, L. C., Walker, L., Lemaitre, H., Barnett, A. S., Marenco, S., & Pierpaoli, C. (2008). Comparison of EPI Distortion Correction Methods in Diffusion Tensor MRI Using a Novel Framework. Medical Image Computing and Computer-Assisted Intervention: MICCAI … International Conference on Medical Image Computing and Computer-Assisted Intervention, 11(Pt 2), 321–329.
Yendiki, A., Koldewyn, K., Kakunoori, S., Kanwisher, N., & Fischl, B. (2014). Spurious group differences due to head motion in a diffusion MRI study. Neuroimage, 88, 79–90. https://doi.org/10.1016/j.neuroimage.2013.11.027.
Zhao, Y., Nebel, M. B., Caffo, B. S., Mostofsky, S. H., & Rosch, K. S. (2022). Beyond massive univariate tests: Covariance regression reveals complex patterns of functional connectivity related to attention-deficit/hyperactivity disorder, age, sex, and response control. Biological Psychiatry Global Open Science, 2(1), 8–16. https://doi.org/10.1016/j.bpsgos.2021.06.003.
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This work was supported by the NIH with grants awarded to KSR (K23-MH101322, R03-MH119457), SHM (R01-MH078160 and R01-MH085328), and P50HD103538. The MRI equipment in this study was funded by NIH grant 1S10OD021648. These sponsors had no role in the study design, collection of data, analysis of data, or interpretation of data.
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Peterson, R.K., Duvall, P., Crocetti, D. et al. ADHD-related sex differences in frontal lobe white matter microstructure and associations with response control under conditions of varying cognitive load and motivational contingencies. Brain Imaging and Behavior 17, 674–688 (2023). https://doi.org/10.1007/s11682-023-00795-1
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DOI: https://doi.org/10.1007/s11682-023-00795-1