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Aberrant brain connectivity is associated with childhood maltreatment in individuals with major depressive disorder

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Abstract

Although childhood maltreatment confers a high risk for the development of major depressive disorder, the neurobiological mechanisms underlying this connection remain unknown. The present study sought to identify the specific resting-state networks associated with childhood maltreatment. We recruited major depressive disorder patients with and without a history of childhood maltreatment (n = 31 and n = 30, respectively) and healthy subjects (n = 80). We used independent component analysis to compute inter- and intra- network connectivity. We found that individuals with major depressive disorder and childhood maltreatment could be characterized by the following network disconnectivity model relative to healthy subjects: (i) decreased intra-network connectivity in the left frontoparietal network and increased intra-network connectivity in the right frontoparietal network, (ii) decreased inter-network connectivity in the posterior default mode network—auditory network, posterior default mode network—limbic system, posterior default mode network—anterior default mode network, auditory network—medial visual network, lateral visual network - medial visual network, medial visual network—sensorimotor network, medial visual network - anterior default mode network, occipital pole visual network—dorsal attention network, and posterior default mode network—anterior default mode network, and (iii) increased inter-network connectivity in the sensorimotor network—ventral attention network, and dorsal attention network—ventral attention network. Moreover, we found significant correlations between the severity of childhood maltreatment and the intra-network connectivity of the frontoparietal network. Our study demonstrated that childhood maltreatment is integrally associated with aberrant network architecture in patients with major depressive disorder.

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Acknowledgment

We thank our participants for their readiness to engage in this study. We thank Sydney Koke, MFA, from Liwen Bianji (Edanz) (www.liwenbianji.cn), for editing the English text of a draft of this manuscript.

Funding

The Guangdong Natural Science Foundation, China (2015A030313800 to HP) supported the design of the study. The Guangzhou municipal key discipline in medicine for Guangzhou Brain Hospital (GBH2014-ZD04 to HP) supported the data collection of the study.

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Authors and Affiliations

  1. Department of Clinical Psychology, The Affiliated Brain Hospital of Guangzhou Medical University, No.36, Mingxin Road, Liwan District, Guangzhou, 510370, China

    Qianyi Luo, Juran Chen, Yuhong Li, Zhiyao Wu, Xinyi Lin, Jiazheng Yao, Huiwen Yu & Hongjun Peng

  2. Department of Radiology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, 510370, China

    Huawang Wu

  3. Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, 510370, China

    Huawang Wu & Hongjun Peng

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  1. Qianyi Luo
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  2. Juran Chen
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Contributions

HP, HW and QL designed the study and drafted the primary manuscript. HW, ZW, and QL supervised the recruitment and made statistical analyses. JC, LQ and YL took part in recruitment and data management. HP and HW made further revisions of the manuscript. All the authors had read and approved the final manuscript.

Corresponding authors

Correspondence to Huawang Wu or Hongjun Peng.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Luo, Q., Chen, J., Li, Y. et al. Aberrant brain connectivity is associated with childhood maltreatment in individuals with major depressive disorder. Brain Imaging and Behavior 16, 2021–2036 (2022). https://doi.org/10.1007/s11682-022-00672-3

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