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Spontaneous neural activity in the right fusiform gyrus and putamen is associated with consummatory anhedonia in obsessive compulsive disorder

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Abstract

Background

Accumulating evidence indicated that anhedonia as a transdiagnostic construct might be an inherent feature of obsessive–compulsive disorder(OCD). Moreover, our recent study demonstrated that OCD patients exhibited consummatory anhedonia but not anticipatory anhedonia. However, neural mechanisms of consummatory anhedonia in OCD has not been explored. This study aimed to investigate this issue using resting-state functional magnetic resonance imaging (fMRI).

Methods

44 OCD patients with high consummatory anhedonia(OCD-HCA), 41 OCD patients with low consummatory anhedonia(OCD-LCA) and 47 healthy controls (HC) underwent fMRI scan. Spontaneous neural activity was analyzed and compared among the three groups by adopting the amplitude of low-frequency fluctuation (ALFF). Relationships between the consummatory anhedonia levels and regional ALFFs were examined in OCD patients.

Results

Compared with HC, OCD-HCA showed decreased ALFF in the right putamen and right thalamus, and OCD-LCA showed increased ALFF in the right orbitofrontal cortex and decreased ALFF in the right fusiform gyrus, left Precentral/postcentral gyrus. Notably, ALFF values differed between the two patient groups in the right putamen (OCD-HCA < OCD-LCA), and right fusiform gyrus (OCD-HCA > OCD-LCA). Further analysis revealed that the consummatory anhedonia was positively correlated with ALFF values in the right fusiform, and negatively correlated with ALFFs in the right putamen.

Conclusions

Spontaneous neural activity in right fusiform gyrus and right putamen is associated with consummatory anhedonia in OCD. The findings provided first insights into neural mechanism of consummatory anhedonia in OCD and confirmed the importance of exploring the transdiagnostic role of anhedonia.

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Data availability

The datasets used or analysed during the current study are available from the corresponding author on reasonable request.

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Funding

This work was financially supported by Grant from the National Natural Science Foundation of China (grant no. 81671341).

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Authors and Affiliations

  1. Medical Psychological Center, the Second Xiangya Hospital, Central South University, 139 Renmin Road, Changsha, Hunan, 410011, People’s Republic of China

    Hongyu Du, Jie Xia, Jie Fan, Feng Gao, Xiang Wang, Yan Han & Xiongzhao Zhu

  2. Medical Psychological Institute of Central South University, Changsha, Hunan, 410011, People’s Republic of China

    Hongyu Du & Xiongzhao Zhu

  3. National Clinical Research Center for Mental Disorders, Changsha, Hunan, 410011, People’s Republic of China

    Xiongzhao Zhu

  4. Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China

    Changlian Tan

Authors
  1. Hongyu Du
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  2. Jie Xia
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  3. Jie Fan
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  4. Feng Gao
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  5. Xiang Wang
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  6. Yan Han
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  7. Changlian Tan
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  8. Xiongzhao Zhu
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Contributions

Hongyu Du: Data curation, study design, data analysis, Writing—original draft. Jie Xia: Data curation, review & editing. Jie Fan: review. Feng Gao: Data curation. Xiang Wang: editing. Yan Han: Data curation. Changlian Tan: Conceptualization, Supervision. Xiongzhao Zhu: Conceptualization, Supervision.

Corresponding author

Correspondence to Xiongzhao Zhu.

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Du, H., Xia, J., Fan, J. et al. Spontaneous neural activity in the right fusiform gyrus and putamen is associated with consummatory anhedonia in obsessive compulsive disorder. Brain Imaging and Behavior 16, 1708–1720 (2022). https://doi.org/10.1007/s11682-021-00619-0

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