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Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx)

  • SI: Pacific Rim 2020
  • Published:
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Abstract

Traumatic brain injury (TBI) can produce heterogeneous injury patterns including a variety of hemorrhagic and non-hemorrhagic lesions. The impact of lesion size, location, and interaction between total number and location of contusions may influence the occurrence of seizures after TBI. We report our methodologic approach to this question in this preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). We describe lesion identification and segmentation of hemorrhagic contusions by early posttraumatic magnetic resonance imaging (MRI). We describe the preliminary methods of manual lesion segmentation in an initial cohort of 32 TBI patients from the EpiBioS4Rx cohort and the preliminary association of hemorrhagic contusion and edema location and volume to seizure incidence.

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Data availability

The data analyzed in this study is subject to the following licenses/restrictions: access to data must be requested and approved by the EpiBioS4Rx steering committee. Requests to access these datasets should be directed to epibiossteeringcommittee@loni.usc.edu.

Code availability

Data processing and analysis were performed with Oxford FMRIB Software Library (FSL) and R version 3.6.3 that are publicly available at the following links:

https://www.r-project.org/

https://fsl.fmrib.ox.ac.uk/fsl/fslwiki

Notes

  1. https://epibios.loni.usc.edu

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Acknowledgements

Data used in the preparation of this article were obtained from the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) database (https://epibios.loni.usc.edu). EpiBioS4Rx was funded by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) in 2017. EpiBioS4Rx is a large, international, multi-site Center without Walls (CWOW) which has been collecting longitudinal EEG, imaging, and blood data from human patients and an animal model with the primary goal to identify biomarkers of epileptogenesis after a traumatic brain injury and then provide therapies and treatments that may stop the development of posttraumatic epilepsy. EpiBioS4Rx is the result of efforts of many investigators from a broad range of academic institutions and private corporations, and subjects have been recruited from over 30 sites across the world. EpiBioS4Rx data are disseminated by the Laboratory of Neuro Imaging at the University of Southern California.

We would like to acknowledge the following EpiBioS4Rx investigators and collaborators: Agoston, Denes, Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences; Au, Alicia K., Critical Care Medicine, University of Pittsburgh Medical Center; Bell, Michael, Critical Care Medicine, Children’s National Hospital DC; Churn, Ben, NINDS, National Institute of Health; Claassen, Jan, Neurology, Columbia University; Diaz-Arrastia, Ramon, Neurology, University of Pennsylvania; Foreman, Brandon, Neurology and Rehabilitation Medicine, University of Cincinnati Medical Center; Galanopoulou, Aristea, Neurology, Albert Einstein College of Medicine; Hunn, Martin, Neurosurgery, The Alfred/Monash University; Jette, Nathalie, Neurology, Icahn School of Medicine at Mount Sinai; Morokoff, Andrew, Surgery, Royal Melbourne Hospital/The University of Melbourne; Moshé, Solomon L., Neurology, Albert Einstein College of Medicine; O’Brien, Terence, Neurology, The Alfred/Monash University/The University of Melbourne; Laing, Joshua, Neurology, The Alfred/Monash University; Perucca, Piero, Neurology, The Royal Melbourne Hospital/ Monash University; O’Phelan, Kristine H., Neurology, University of Miami; Pitkanen, Asla, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland; Courtney Real, Neurosurgery, University of California Los Angeles; Ellingson, Ben, Radiology, University of California Los Angeles; Jesus E. Ruiz Tajeda, University of California Los Angeles; Buitrago Blanco, Manuel, Neurology, University of California Los Angeles; Correa, Daniel, Neurology, Montefiore Medical Center; Harrar, Dana, Pediatrics, Children’s National Hospital DC; Bleck, Thomas P., Neurology, Northwestern University; Burrows, Brian, Phoenix Children’s Hospital; Appavu, Brian, Neurology, Phoenix Children’s Hospital; Struck, Aaron, Neurology, University of Wisconsin; Allen, Baxter, Neurology, Weill Cornell; Keselman, Inna, Neurology, University of California Los Angeles Health; Kennedy, Jeff, Neurology, University of California Davis Medical Center; Ferastraoaru, Victor, Neurology, Albert Einstein College of Medicine; Yoo, Ji Yeoun, Neurology, Icahn School of Medicine at Mount Sinai.

Funding

This study was conducted with the support of the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) under award number U54 NS100064 (EpiBioS4Rx).

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Authors and Affiliations

  1. Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA

    Marianna La Rocca, Giuseppe Barisano, Alexis Bennett, Rachael Garner, James Stanis, Arthur W. Toga & Dominique Duncan

  2. David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA

    Jerome Engel, David L. McArthur & Paul Vespa

  3. Comprehensive Epilepsy Center, Department of Neurology, Yale University, New Haven, CT, USA

    Emily J. Gilmore

  4. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Eric Rosenthal

  5. Phoenix Children’s Hospital, Phoenix, AZ, USA

    Frederick Willyerd

  6. University of California Davis Medical Center, Sacramento, CA, USA

    Lara L. Zimmermann

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  1. Marianna La Rocca
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for the EpiBioS4Rx Study Group

Contributions

M.L.R., D.D. and A.T. conceived the work. M.L.R. and A.B. conducted the analyses and wrote the manuscript. E.G., E.R., F.W., L.Z. and P.V. collected the data. G.B., J.E., E.G., E.R., F.W., L.Z. and P.V. reviewed clinically the work. J.S. produced 3D animations. All authors M.L.R., G.B., A.B., R.G., J.E., E.G., D.M., E.R., J.S., F.W., L.Z., P.V, A.T. and D.D. analyzed the results, reviewed the manuscript, approved the final version to be published and agreed to be accountable for the integrity and accuracy of all aspects of the work.

Corresponding author

Correspondence to Marianna La Rocca.

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Conflicts of Interest/Competing interests

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Ethics approval

This work was approved by the UCLA Institutional Review Board (IRB# 16–001 576) and the local review boards at each EpiBioS4Rx Study Group institution. Assent and written consent was obtained from the legal representative as per state law.

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All patients have consented for data to be deidentified and then analyzed.

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Not Applicable.

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This study was conducted with the support of the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) under award number U54 NS100064 (EpiBioS4Rx). We have no conflicts of interest to disclose.

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La Rocca, M., Barisano, G., Bennett, A. et al. Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). Brain Imaging and Behavior 15, 2804–2812 (2021). https://doi.org/10.1007/s11682-021-00603-8

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