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The ENIGMA Brain Injury working group: approach, challenges, and potential benefits

  • SI: ENIGMA TBI
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Abstract

The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium brings together researchers from around the world to try to identify the genetic underpinnings of brain structure and function, along with robust, generalizable effects of neurological and psychiatric disorders. The recently-formed ENIGMA Brain Injury working group includes 10 subgroups, based largely on injury mechanism and patient population. This introduction to the special issue summarizes the history, organization, and objectives of ENIGMA Brain Injury, and includes a discussion of strategies, challenges, opportunities and goals common across 6 of the subgroups under the umbrella of ENIGMA Brain Injury. The following articles in this special issue, including 6 articles from different subgroups, will detail the challenges and opportunities specific to each subgroup.

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Acknowledgements

We acknowledge funding sources including K99 NS096116 to Dr. Dennis and PT12051 and I01 RX002174 (CENC) to Drs. Wilde, Tate, and Dennis. The authors wish to acknowledge the leadership of Dr. Paul Thompson (ENIGMA PI) as well as the leadership of Drs. Frank Hillary, Alexander Olsen, Inga Koerte, David Baron, Alexander Lin, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, and Neda Jahanshad, as well as ENIGMA support personnel and all working group members and contributors. We wish to acknowledge the contribution of Eamonn Kennedy in the conceptualization and creation of the figures. We also wish to thank all participants who have contributed to this research. Finally, we extend our gratitude to Drs. Erin D. Bigler and Martha E. Shenton for their thoughtful review of this manuscript and their enduring mentorship and support.

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Authors and Affiliations

  1. TBICC, Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT, USA

    Elisabeth A. Wilde, Emily L. Dennis & David F. Tate

  2. George E. Wahlen VA Medical Center, Salt Lake City, UT, USA

    Elisabeth A. Wilde, Emily L. Dennis & David F. Tate

  3. H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA

    Elisabeth A. Wilde

  4. Psychiatry Neuroimaging Laboratory, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Emily L. Dennis

  5. Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, Los Angeles, CA, USA

    Emily L. Dennis

  6. Missouri Institute of Mental Health, University of Missouri, St. Louis, MO, USA

    David F. Tate

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  1. Elisabeth A. Wilde
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  2. Emily L. Dennis
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Correspondence to Emily L. Dennis.

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Wilde, E.A., Dennis, E.L. & Tate, D.F. The ENIGMA Brain Injury working group: approach, challenges, and potential benefits. Brain Imaging and Behavior 15, 465–474 (2021). https://doi.org/10.1007/s11682-021-00450-7

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