Abstract
Protracted abstinence (PA) and Methadone maintenance treatment (MMT) are two main types of heroin addiction treatment, however, the effects of both measures on the functional connectivity (FC) of the brain in heroin dependents in the drug cue event-related response are unclear. Functional magnetic resonance imaging (fMRI) based drug cue-reactivity task has been widely used in addiction research, which may provide a new way to understand the change of brain function during a certain period of treatment. The default function network (DMN) with posterior cingulate cortex (PCC) as the core is generally involved in the process of addiction. The aim of the present study was to explore the brain response of FC in patients with heroin-dependent during PA, MMT treatment under task-fMRI. Twenty-two heroin-dependent patients during PA, 18 heroin-dependent patients during MMT and 16 healthy control (HC) individuals were included to conduct the heroin cue-reactivity task during fMRI. The MMT and PA patients’ subjective craving for heroin was evaluated. The psychophysiological interaction (PPI) analysis of SPM12 was used to get FC during the task state. There was a significant difference on FC between PCC and the right medial Prefrontal Cortex (mPFC) in three groups. The post-hoc analysis showed that there was a significant difference of brain regions between the MMT and the PA group. The FC of PCC-mPFC in the MMT group was significantly stronger than that in the PA group. Compared with the PA group, the FC of the DMN in the MMT group was significantly increased under drug cue response. Therefore, PA is more beneficial for the heroin-dependent patients to lower the salience value of drug related cues, in turn to reduce relapse risks. It also reflected the important role of PCC-mPFC pathway in heroin dependents induced by heroin cues.
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Acknowledgments
We thank Mr. Xinhai Wu for contributions to the recruitment of heroin-dependent subjects.
Funding
This study was funded by National Natural Science Foundation of China (81771813, 81671661 and 81401393), Technology Innovation Development Foundation of Tangdu Hospital (2013LCYJ003), Reserve Talents Foundation of Tangdu Hospital (2016), Science and Technology Development Fund of the fourth military medical university (2017XD062), China Postdoctoral Science Foundation (2020 M680607), and Research Foundation of Beijing Friendship Hospital, Capital Medical University (yyqdkt2019–31).
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Wei, X., Chen, J., Zhu, J. et al. Functional connectivity of posterior cingulate gyrus in heroin dependents treated by methadone maintenance and protracted abstinence measures: an event-related fMRI study. Brain Imaging and Behavior 15, 2472–2480 (2021). https://doi.org/10.1007/s11682-020-00447-8
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DOI: https://doi.org/10.1007/s11682-020-00447-8