Abstract
Adolescent-onset schizophrenia (AOS) is a severe neuropsychiatric disease associated with frequency-specific abnormalities across distributed neural systems in a slow rhythm. Recently, functional magnetic resonance imaging (fMRI) studies have determined that the global signal. (GS) is an important source of the local neuronal activity in 0.01–0.1 Hz frequency band. However, it remains unknown whether the effects follow a specific spatially preferential pattern in different frequency bands in schizophrenia. To address this issue, resting-state fMRI data from 39 drug-naïve AOS patients and 31 healthy controls (HCs) were used to assess the changes in GS topography patterns in the slow-4 (0.027–0.073 Hz) and slow-5 bands (0.01–0.027 Hz). Results revealed that GS mainly affects the default mode network (DMN) in slow-4 and sensory regions in the slow-5 band respectively, and GS has a stronger driving effect in the slow-5 band. Moreover, significant frequency-by-group interaction was observed in the frontoparietal network. Compared with HCs, patients with AOS exhibited altered GS topography mainly located in the DMN. Our findings demonstrated that the influence of the GS on brain networks altered in a frequency-specific way in schizophrenia.
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This research was supported by the National Key Project of Research and Development of Ministry of Science and Technology (2018AAA0100705), the Natural Science Foundation of China (61,533,006, u1808204, 61,806,042 and 61,673,089), and the Sichuan Science and Technology Program(2018TJPT0016 and 2019YJ0180).
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Wang, X., Liao, W., Han, S. et al. Frequency-specific altered global signal topography in drug-naïve first-episode patients with adolescent-onset schizophrenia. Brain Imaging and Behavior 15, 1876–1885 (2021). https://doi.org/10.1007/s11682-020-00381-9
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DOI: https://doi.org/10.1007/s11682-020-00381-9