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Different patterns of functional and structural alterations of hippocampal sub-regions in subcortical vascular mild cognitive impairment with and without depression symptoms

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Abstract

In addition to cognitive impairments, depression symptoms were reported in subcortical vascular mild cognitive impairment. Although hippocampal alterations were associated with cognitive decline in subcortical vascular mild cognitive impairment, the neural mechanism underlying depression symptoms remains unclear. Thus, a cohort of 18 patients with depression symptoms, 17 patients without depression symptoms, and 23 normal controls was used. Functionally, significantly altered resting-state functional connectivity between hippocampal emotional sub-region and right posterior cingulate cortex, between hippocampal cognitive sub-region and right inferior parietal gyrus and between hippocampal perceptual sub-region and left inferior temporal gyrus were identified among three groups. Structurally, significantly altered structural associations between hippocampal emotional sub-region and 6 frontal regions/right pole part of superior temporal gyrus/right inferior occipital gyrus, between hippocampal cognitive sub-region and right orbital part of inferior frontal gyrus /right anterior cingulate cortex, and between hippocampal perceptual and right orbital part of inferior frontal gyrus / left inferior temporal gyrus / left thalamus were identified among the three groups. Further analyses also showed correlations between functional connectivity and depression symptoms and/or cognitive impairments of patients. Together, these results showed different patterns of functional and structural alterations of the hippocampal sub-regions in the subcortical vascular mild cognitive impairment with and without depression, which might be specially associated with the depression symptoms and cognitive impairments in these patients.

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Funding

This work was supported by the Key R&D Program of Guangdong Province (No.2018B030339001), the National Natural Science Foundation of China (61,671,440 and U1713215), the National key research program (No.2017YFC1703606), and Shenzhen Science and Technology Research Program (No.JCYJ20170307155203481 and No.JCYJ20170412174037594).

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  1. Jinping Xu and Jianjun Wang contributed equally to this work.

Authors and Affiliations

  1. Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China

    Jinping Xu, Ziyun Xu & Qingmao Hu

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Jinping Xu, Ziyun Xu & Qingmao Hu

  3. Department of Neurology and Psychiatry, Shenzhen Traditional Chinese Medicine Hospital / the Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China

    Jianjun Wang & Zhouke Guo

  4. Department of Radiology, Shenzhen Traditional Chinese Medicine Hospital / the Fourth Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen, 518033, China

    Hanqing Lyu, Xuejia Pu & Yuanming Hu

  5. Department of Acupuncture and Moxibustion, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, China

    Haibo Yu

  6. CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China

    Qingmao Hu

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Qingmao Hu and Zhouke Guo designed the study. Jianjun Wang, Hanqing Lyu, and Yuanming Hu collected the data. Jinping Xu and Ziyun Xu processed the data. Xuejia Pu helped with statistical analysis. Haibo Yu helped data analyses and revised manuscript. Jinping Xu wrote the manuscript. All authors reviewed the paper and approved the final version to be published.

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Correspondence to Qingmao Hu.

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Xu, J., Wang, J., Lyu, H. et al. Different patterns of functional and structural alterations of hippocampal sub-regions in subcortical vascular mild cognitive impairment with and without depression symptoms. Brain Imaging and Behavior 15, 1211–1221 (2021). https://doi.org/10.1007/s11682-020-00321-7

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