Abstract
Growing evidence has supported that the nucleus accumbens (NAc), especially its shell portion, has been involved in epileptogenesis. However, relevant studies on vivo human brain are quite limited. In this study, we investigated left mesial temporal lobe epilepsy (MTLE) related function connectivity (FC) changes of NAc subregions using resting-state functional magnetic resonance imaging. We calculated functional connectivity from two NAc subregions to both whole brain and 16 related targets. Two-sample t-test (Alphasim multiple comparisons corrected) was performed to identify the effect of the disease on each seed’s whole brain network. Repeated-measures ANOVA and Post hoc pairwise t test (Bonferroni corrections) were performed to visualize the seed to target FC group differences in each subdivision. In whole brain FC networks, neither the left or right core show different FC changes. The left shell showed decreased FC with a cluster located around the right inferior frontal gyrus. The right shell portion showed increased FC with a cluster located around the left inferior temporal gyrus. The seed to targets results showed that the left shell of LTLE group exhibited lower FC with left posterior-parahippocampal gyrus and right caudate, putamen, thalamus, paracingulate gyrus but higher FC with right subcallosal cortex. The right core of LTLE group exhibited higher FC with right frontal pole and the right shell exhibited lower FC with left thalamus and left anterior-parahippocampal gyrus. This is the first study to investigate the functional connectivity changes of NAc subdivisions of epilepsy in vivo human brain. Our results showed that the left MTLE related FC changes on NAc are mainly on shell portion rather than core. The decrease FC between the left shell and right frontal area and the decrease FC between the right shell and left temporal area suggested they serve vital roles for MTLE.
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This study was funded by National Natural Science Foundation Guangdong United Found (grant number U1501256), the science and technology project of Guangdong Province (grant number 2015B010131011), the science and technology project of Guangdong Province (grant number 2015B010106008) and the National Natural Science Foundation of China (grant number 61971275).
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Qianjin Feng, YiKai Xu and Xixi Zhao designed the study; Xixi Zhao collected the data; Ru Yang analyzed the data; Ru Yang and Feng Hou undertook the statistical analysis; Xixi Zhao and Ru Yang wrote the manuscript; Xufeng Yao and Jun Liu contributed to the final manuscript.
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Yang, R., Zhao, X., Liu, J. et al. Functional connectivity changes of nucleus Accumbens Shell portion in left mesial temporal lobe epilepsy patients. Brain Imaging and Behavior 14, 2659–2667 (2020). https://doi.org/10.1007/s11682-019-00217-1
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DOI: https://doi.org/10.1007/s11682-019-00217-1