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Patterns of intrinsic brain activity in essential tremor with resting tremor and tremor-dominant Parkinson’s disease

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Abstract

The clinical pictures of essential tremor (ET) with resting tremor (rET) and tremor-dominant Parkinson’s disease (tPD) are often quite mimic at the early stage, current approaches to the diagnosis and treatment therefore remain challenging. The regional homogeneity (ReHo) method under resting-state functional magnetic resonance imaging (rs-fMRI) would help exhibit the patterns in neural activity, which further contribute to differentiate these disorders and explore the relationship between symptoms and regional functional abnormalities. Sixty-eight Chinese participants were recruited, including 19 rET patients, 24 tPD patients and 25 age- and gender-matched healthy controls (HCs). All participants underwent clinical assessment and rs-fMRI with a ReHo method to investigate the alterations of neural activity, and the correlation between them. Differences were compared by two-sample t-test (corrected with AlphaSim, p < 0.05). Compared with HCs, patients’ groups both displayed decreased ReHo in the default mode network (DMN), bilateral putamen and bilateral cerebellum. While tPD patients specifically exihibited decreased ReHo in the bilateral supplementary motor area (SMA) and precentral gyrus (M1). The correlation analysis revealed that ReHo in the bilateral putamen, right SMA and left cerebellum_crus I were negatively correlated with the UPDRS-III score, respectively, in tPD group. Our results indicated the rET patients may share part of the pathophysiological mechanism of tPD patients. In addition, we found disorder-specific involvement of the SMA and M1 in tPD. Such a distinction may lend itself to use as a potential biomarker for differentiating between these two diseases.

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Acknowledgements

We thank all the patients who participated in this study and are grateful to the Department of Neurology at the West China Hospital for their support of this work. We also gratefully acknowledge Professor Dong Zhou, Li He, Guanggu Yuan and all staffs in the laboratory for their help.

Funding

The study was supported by the National Natural Science Foundation of China (81801272), China Postdoctoral Science Foundation (2017 M610605), Sichuan Science and Technology Program (2018FZ0029 and 2018HH0077), The Fundamental Research Funds for the Central Universities (2018SCU12029), and Post-Doctor Research Project, West China Hospital, Sichuan University (2018HXBH085).

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  1. Jun-ying Li and Zhong-jiao Lu contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People’s Republic of China

    Jun-ying Li, Zhong-jiao Lu, Nan-nan Li, Ling Wang, Jia-xin Peng, Li-ren Duan, Jing Xi, Yi Jiang & Rong Peng

  2. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China

    Xue-ling Suo, Du Lei & Qi-yong Gong

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  1. Jun-ying Li
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Correspondence to Rong Peng.

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Li, Jy., Lu, Zj., Suo, Xl. et al. Patterns of intrinsic brain activity in essential tremor with resting tremor and tremor-dominant Parkinson’s disease. Brain Imaging and Behavior 14, 2606–2617 (2020). https://doi.org/10.1007/s11682-019-00214-4

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