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Altered amygdala resting-state functional connectivity following acupuncture stimulation at BaiHui (GV20) in first-episode drug-Naïve major depressive disorder

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Abstract

Amygdala is an important locus of dysfunction implicated in major depressive disorder(MDD). Aberrant amygdala networks(AN) had been reported in resting-state functional magnetic resonance imaging (rs-fMRI) study. The safety and efficacy of acupuncture treatment for MDD have been verified in previous clinical studies. This study is aimed to investigate whether acupuncture at GV20 could modulate the abnormal AN of patients with the first-episode, drug-naïve MDD by using rs-fMRI combined with functional connectivity (FC) method. Thirty MDD patient underwent 6-min rs-fMRI scans respectively before and after 20-min electro-acupuncture stimulate(EAS) at GV20. Twenty-nine healthy subjects underwent only a 6-min rs-fMRI scan. Based on the amygdala as the seed region, FC method was adopted to examine abnormal AN in patients by comparing with healthy subjects and to evaluate the influence of EAS on intrinsic connectivity within the AN in patients with MDD. Compared to healthy subjects, MDD patients had aberrant intrinsic AN which mainly showed increased FC between amygdala and hippocampus, precuneus, precentral gyrus and angular gyrus, as well as decreased FC between amygdala and orbital frontal cortex(OFC). Moreover, our results indicated that EAS at GV20 induced increased/decreased FC between amygdala and certain regions in MDD patients. In addition, the intrinsic amygdala FC within other certain brain regions in MDD patients were regulated by EAS at GV20. The abnormal AN of MDD patients could be modulated by EAS at GV20. Our findings may further provide the potential imaging evidence to support the modulatory mechanisms of acupuncture on MDD.

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Acknowledgments

The current study was supported by the National Natural Science Foundation of China [Grant Nos. 81760886, 81771918] and the Guangxi Natural Science Foundation [Grant Nos. 2017GXNSFBA198095, 2016GXNSFAA380086].

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  1. Gaoxiong Duan, Qianchao He, Yong Pang and Wenfu Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, 530023, Guangxi, China

    Gaoxiong Duan, Wenfu Chen, Hai Liao, Jian Zhang, Xiaomei Wei, Peiyi Sun & Demao Deng

  2. Department of Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, 530023, Guangxi, China

    Qianchao He & Lulu Tan

  3. Department of Acupuncture, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, 530023, Guangxi, China

    Yong Pang, Huimei Liu & Jien Tao

  4. Life Science Research Center, School of Life Science and Technology, Xidian University, Xi’an, 710071, Shaanxi, China

    Yanfei Liu & Peng Liu

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  1. Gaoxiong Duan
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Contributions

DD, LH and PL obtained funding. DD, YP and PL participated in the study concept and design and final approval of the version to be published. GD, QH, YP and WC recruited volunteers and carried out the experiment. MHL and HL ensured the integrity of the data. LT, JT and YL analyzed the data, and helped to draft the manuscript. JZ, XW and PS drafted the manuscript and revised it critically. GD is the first author and QH, YP and WC are co-first author. All authors read and approved the final manuscript.

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Correspondence to Demao Deng.

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Every subject was clearly told the whole experiment procedure and signed an informed consent in the current study, which was permitted by the Medicine Ethics Committee of First Affiliated Hospital, Guangxi University of Chinese Medicine, Guangxi, China. Procedures of the study were conducted in accordance with the Declaration of Helsinki.

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Duan, G., He, Q., Pang, Y. et al. Altered amygdala resting-state functional connectivity following acupuncture stimulation at BaiHui (GV20) in first-episode drug-Naïve major depressive disorder. Brain Imaging and Behavior 14, 2269–2280 (2020). https://doi.org/10.1007/s11682-019-00178-5

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