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Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults

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Abstract

Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The present study examines the correspondence between white matter fiber bundle length and behavioral inhibition in 37 community-dwelling older adults (aged 51–78 years). Participants underwent neuroimaging with 3 Tesla MRI, and completed a behavioral test of inhibition (i.e., Go/NoGo task). Quantitative tractography derived from diffusion tensor imaging (qtDTI) was used to measure white matter fiber bundle lengths (FBLs) in tracts known to innervate frontal brain regions, including the anterior corpus callosum (AntCC), the cingulate gyrus segment of the cingulum bundle (CING), uncinate fasciculus (UNC), and the superior longitudinal fasciculus (SLF). Performance on the Go/NoGo task was measured by the number of commission errors standardized to reaction time. Hierarchical regression models revealed that shorter FBLs in the CING (p < 0.05) and the bilateral UNC (p < 0.01) were associated with lower inhibitory performance after adjusting for multiple comparisons, supporting a disconnection model of response inhibition in older adults. Prospective longitudinal studies are needed to examine the evolution of inhibitory errors in older adult populations and potential for therapeutic intervention.

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Funding

Supported by National Institutes of Health/National Institute of Neurological Disorders and Stroke grant number R01 NS052470 and R01 NS039538, National Institutes of Health/National Institute of Mental Health grant R21 MH090494.

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Authors and Affiliations

  1. Department of Psychological Sciences, University of Missouri, St. Louis, MO, 63121, USA

    Paola M. Garcia-Egan & Robert H. Paul

  2. Missouri Institute of Mental Health, St. Louis, MO, 63134, USA

    Rebecca N. Preston-Campbell, Jodi M. Heaps-Woodruff, Lila Balla & Robert H. Paul

  3. Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, CA, 90292, USA

    Lauren E. Salminen

  4. Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, LosAngeles, CA, 90033, USA

    Ryan P. Cabeen

  5. Department of Computer Science, Brown University, Providence, RI, 02906, USA

    David H. Laidlaw

  6. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA

    Thomas E. Conturo

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  2. Rebecca N. Preston-Campbell
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  3. Lauren E. Salminen
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  4. Jodi M. Heaps-Woodruff
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  6. Ryan P. Cabeen
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  7. David H. Laidlaw
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  9. Robert H. Paul
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Corresponding author

Correspondence to Robert H. Paul.

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Conflict of interest

Drs. Paul, Heaps, Salminen, Preston-Campbell, Cabeen, Laidlaw, Conturo, and Ms. García-Egan declare no conflicts of interest.

Informed consent

All procedures were in accordance with the ethical standards of the responsible committee in research involving human subjects (Institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all participants.

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Garcia-Egan, P.M., Preston-Campbell, R.N., Salminen, L.E. et al. Behavioral inhibition corresponds to white matter fiber bundle integrity in older adults. Brain Imaging and Behavior 13, 1602–1611 (2019). https://doi.org/10.1007/s11682-019-00144-1

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