Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention

Kong, Jian; Wolcott, Emily; Wang, Zengjian; Jorgenson, Kristen; Harvey, William F.; Tao, Jing; Rones, Ramel; Wang, Chenchen

doi:10.1007/s11682-018-9875-3

Original Research
Published: 02 May 2018

Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention

Jian Kong¹,
Emily Wolcott²,
Zengjian Wang¹,
Kristen Jorgenson¹,
William F. Harvey²,
Jing Tao¹,
Ramel Rones¹ &
Chenchen Wang²

Brain Imaging and Behavior volume 13, pages 482–492 (2019)Cite this article

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Abstract

This study examines altered resting state functional connectivity (rsFC) of the cognitive control network (CCN) in fibromyalgia patients as compared to healthy controls, as well as how an effective mind-body intervention, Tai Chi, can modulate the altered rsFC of the CCN. Patients with fibromyalgia and matched healthy subjects were recruited in this study. Fibromyalgia patients were scanned 12 weeks before and after intervention. The bilateral dorsolateral prefrontal cortex (DLPFC) was used as a seed to explore the rsFC of the CCN. Data analysis was conducted with 21 patients and 20 healthy subjects. Compared to healthy subjects, fibromyalgia patients exhibited increased rsFC between the DLPFC and the bilateral rostral anterior cingulate cortex (rACC) and medial prefrontal cortex (MPFC) at baseline. The rsFC between the CCN and rACC/MPFC further increased after Tai Chi intervention, and this increase was accompanied by clinical improvements. This rsFC change was also significantly associated with corresponding changes in the Overall Impact domain of the Revised Fibromyalgia Impact Questionnaire (FIQR). Further analysis showed that the rACC/MPFC rsFC with both the PAG and hippocampus significantly decreased following Tai Chi intervention. Our study suggests that fibromyalgia is associated with altered CCN rsFC and that effective mind-body treatment may elicit clinical improvements by further increasing this altered rsFC. Elucidating this mechanism of enhancing the allostasis process will deepen our understanding of the mechanisms underlying mind-body interventions in fibromyalgia patients and facilitate the development of new pain management methods.

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Acknowledgements

Dr. Chenchen Wang is supported by R01 AT005521, R01AT006367 and K24AT007323, the National Center for Research Resources, National Institutes of Health (UL1 RR025752) and the National Center for Advancing Translational Sciences, National Institutes of Health (UL1TR000073 and UL1TR001064). Dr. Jian Kong is supported by R01AT006364, R01AT008563, R61 AT009310, R21AT008707, and P01 AT006663 from NIH/NCCIH. We also thank Courtney Lang for her help in manuscript revision and proof reading.

Funding

This study was supported by the National Center for Complementary and Integrative Health of the National Institutes of Health (R01 AT005521, R01 AT006367 and K24 AT007323, R01AT006364, R01 AT008563, R21AT008707, R61 AT009310, and P01 AT006663 from NIH/NCCIH), the National Center for Research Resources, National Institutes of Health (UL1 RR025752) and the National Center for Advancing Translational Sciences, National Institutes of Health (UL1TR000073 and UL1TR001064).

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Affiliations

Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
Jian Kong, Zengjian Wang, Kristen Jorgenson, Jing Tao & Ramel Rones
Center For Complementary And Integrative Medicine, Department of Rheumatology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA
Emily Wolcott, William F. Harvey & Chenchen Wang

Authors

Jian Kong
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Emily Wolcott
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Zengjian Wang
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Kristen Jorgenson
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William F. Harvey
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Jing Tao
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Ramel Rones
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Chenchen Wang
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Contributions

Experimental design: Chenchen Wang, Jian Kong, Ramel Rones, William F Harvey.

Data collection: Jian Kong, Emily Wolcott, Jing Tao, Kristen Jorgenson, William F Harvey.

Data analysis: Zengjian Wang, Jian Kong.

Manuscript preparation: Jian Kong, Zengjian Wang, Chenchen Wang, Kristen Jorgenson, William F Harvey.

Corresponding authors

Correspondence to Jian Kong or Chenchen Wang.

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Conflict of interest

Jian Kong holds equity of a start-up Inc. (MNT). All authors declare that they have no competing financial interests.

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Kong, J., Wolcott, E., Wang, Z. et al. Altered resting state functional connectivity of the cognitive control network in fibromyalgia and the modulation effect of mind-body intervention. Brain Imaging and Behavior 13, 482–492 (2019). https://doi.org/10.1007/s11682-018-9875-3

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Published: 02 May 2018
Issue Date: 15 April 2019
DOI: https://doi.org/10.1007/s11682-018-9875-3

Keywords

Resting state functional connectivity
Fibromyalgia
Cognitive control network
Dorsal lateral prefrontal cortex
Tai Chi
Anterior cingulate cortex
Mind-body intervention