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Functional connectivity change between posterior cingulate cortex and ventral attention network relates to the impairment of orientation for time in Alzheimer’s disease patients

  • Ken-ichiro Yamashita
  • Taira Uehara
  • Pukovisa Prawiroharjo
  • Koji Yamashita
  • Osamu Togao
  • Akio Hiwatashi
  • Yoshihide Taniwaki
  • Hidetsuna Utsunomiya
  • Takuya Matsushita
  • Ryo Yamasaki
  • Jun-ichi Kira
Original Research

Abstract

Alzheimer’s disease (AD) patients exhibit various cognitive dysfunctions, including impairment of orientation for time (OT). The brain regions underlying OT impairment remain to be elucidated. A previous single-photon emission computed tomography study has indicated hypoperfusion of the posterior cingulate cortex (PCC) in relation to deterioration of OT. In this study, we investigated whole brain functional connectivity changes of PCC using resting-state functional magnetic resonance imaging. Voxel-based functional connectivity with PCC was analyzed in OT-poor or OT-good AD patients, classified according to the mean OT scores of the Mini-Mental State Examination subscale. The connectivities of dorsal frontal lobe, and lateral parietal and lateral temporal lobes with PCC in the right hemisphere were reduced in the OT-poor AD group compared with the OT-good AD group. A subtraction connectivity map of OT score differences (OT-good minus OT-poor) revealed the right middle temporal gyrus near the temporo-parietal junction as a significantly connected region with PCC. These results suggest that the right posterior part of the middle temporal gyrus may play an important role in OT in conjunction with PCC, and that disconnection between PCC and the right ventral attention network may cause OT disturbance in AD patients.

Keywords

Alzheimer’s disease Orientation for time Resting-state fMRI Posterior cingulate cortex Middle temporal gyrus Attention network 

Notes

Acknowledgements

This work was supported in part by a Grant-in-Aid for Scientific Research (C) to K.Y. (15 K09353) from the Japan Society for the Promotion of Science (JSPS), Japan.

Compliance with ethical standards

Conflict of interest

Ken-ichiro Yamashita, Taira Uehara, Pukovia Prawiroharjo, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Yoshihide Taniwaki, Hidetsuna Utsunomiya, Takuya Matsushita, Ryo Yamasaki and Jun-ichi Kira report no conflicts of interest.

Informed consent

All procedures performed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975. Informed consent was obtained from all patients included in the study.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ken-ichiro Yamashita
    • 1
  • Taira Uehara
    • 1
  • Pukovisa Prawiroharjo
    • 1
  • Koji Yamashita
    • 2
  • Osamu Togao
    • 2
  • Akio Hiwatashi
    • 2
  • Yoshihide Taniwaki
    • 3
  • Hidetsuna Utsunomiya
    • 4
  • Takuya Matsushita
    • 1
  • Ryo Yamasaki
    • 1
  • Jun-ichi Kira
    • 1
  1. 1.Department of Neurology, Neurological Institute, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  2. 2.Department of Clinical Radiology, Graduate School of Medical SciencesKyushu UniversityFukuokaJapan
  3. 3.Department of NeurologyFukuoka Sanno HospitalFukuokaJapan
  4. 4.Department of RadiologyFukuoka Sanno HospitalFukuokaJapan

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