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Quantitative susceptibility mapping as a biomarker for evaluating white matter alterations in Parkinson’s disease

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Abstract

Myelinated white matter showing diamagnetic susceptibility is important for information transfer in the brain. In Parkinson’s disease (PD), the white matter is also suffering degenerative alterations. Quantitative susceptibility mapping (QSM) is a novel technique for noninvasive assessment of regional white matter ultrastructure, and provides different information of white matter in addition to standard diffusion tensor imaging (DTI). In this study, we used QSM to detect spatial white matter alterations in PD patients (n = 65) and age- and sex-matched normal controls (n = 46). Voxel-wise tract-based spatial statistics were performed to analyze QSM and DTI data. QSM showed extensive white matter involvement—including regions adjacent to the frontal, parietal, and temporal lobes—in PD patients, which was more widespread than that observed using DTI. Both QSM and DTI showed similar alterations in the left inferior longitudinal fasciculus and right cerebellar hemisphere. Further, alterations in the white matter were correlated with motor impairment and global disease severity in PD patients. We suggest that QSM may provide a novel approach for detecting white matter alterations and underlying network disruptions in PD. Further, the combination of QSM and DTI would provide a more complete evaluation of the diseased brain by analyzing different biological tissue properties.

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Acknowledgements

We wish to thank all the participants including patients with Parkinson’s disease and normal volunteers. We also thank the assistance from department of Neurology in our institute. Finally, Xiaojun Guan would like to personally thank Dr. Jingrui Jin, for her infinite patience, care and love.

Funding

This work was supported by the 13th Five-year Plan for National Key Research and Development Program of China (Grant No. 2016YFC1306600), the Fundamental Research Funds for the Central Universities of China (2017XZZX001-01), the 12th Five-year Plan for National Science and Technology Supporting Program of China (Grant No. 2012BAI10B04) and the National Natural Science Foundation of China (Grant Nos. 81571654, 81371519, 81701647 and 81771820). P.H. was supported in part by the Projects of Medical and Health Technology Development Program in Zhejiang Province (2015KYB174) and C.L. was supported in part by the National Institutes of Health through grants NIMH R01MH096979, and by the National Natural Science Foundation of China (Grant No. 81428013).

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  1. Xiaojun Guan and Peiyu Huang contribute equally to this paper.

Authors and Affiliations

  1. Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Xiaojun Guan, Peiyu Huang, Qiaoling Zeng, Min Xuan, Quanquan Gu, Xiaojun Xu, Xinfeng Yu, Xiao Luo & Minming Zhang

  2. Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA, USA

    Chunlei Liu & Hongjiang Wei

  3. Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA

    Chunlei Liu

  4. Brain Imaging and Analysis Center, Duke University School of Medicine, Durham, NC, USA

    Nian Wang

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  1. Xiaojun Guan
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Correspondence to Minming Zhang.

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Guan, X., Huang, P., Zeng, Q. et al. Quantitative susceptibility mapping as a biomarker for evaluating white matter alterations in Parkinson’s disease. Brain Imaging and Behavior 13, 220–231 (2019). https://doi.org/10.1007/s11682-018-9842-z

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