Abnormal interaction between cognitive control network and affective network in patients with end-stage renal disease

Mu, Junya; Chen, Tao; Liu, Qianqian; Ding, Dun; Ma, Xueying; Li, Peng; Li, Anmao; Huang, Mingxia; Zhang, Zengjun; Liu, Jixin; Zhang, Ming

doi:10.1007/s11682-017-9782-z

Original Research
Published: 23 October 2017

Abnormal interaction between cognitive control network and affective network in patients with end-stage renal disease

Junya Mu^1,2,
Tao Chen^1,2,
Qianqian Liu^1,2,
Dun Ding³,
Xueying Ma³,
Peng Li³,
Anmao Li^3,4,
Mingxia Huang⁴,
Zengjun Zhang⁴,
Jixin Liu^1,2 &
Ming Zhang³

Brain Imaging and Behavior volume 12, pages 1099–1111 (2018)Cite this article

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Abstract

End-stage renal disease (ESRD) is a common complicated disorder that is generally associated with an altered central nervous system and cognitive impairment. Neuroimaging studies have recorded aberrant brain circuits in patients with ESRD that were closely associated with abnormal clinical manifestations. However, whether the altered interaction was within and/or between these circuits is largely unclear. We investigated brain topological organization and/or module interaction by employing resting-state functional magnetic resonance imaging (rs-fMRI) and modularity network analysis in 24 patients with ESRD and 20 age- and gender-matched healthy control (HC) subjects. Stroop task was used to evaluate the performance of cognitive control in all subjects. At the global level, ESRD patients exhibited significantly decreased global and local efficiency which were mainly related to abnormal functional connectivity of the amygdala and inferior frontal gyrus (IFG). Stepwise regression analysis was applied to estimate the relationships between network efficiency and blood biochemistry level (urea, creatine, phosphate, Ca²⁺, hematocrit, cystatin, hemoglobin levels, parathyroid hormone, K⁺ and Na⁺), and only the hematocrit level was significantly associated with global efficiency in patients with ESRD. At the modular level, we discovered an aberrant brain interaction between the amygdala- and IFG-related circuits in the ESRD group, and the regional efficiency of the amygdala was observably relative to the performance of cognitive control in patients with ESRD. Our results suggested that ESRD exhibited aberrant brain functional topological organization and module-level interaction between the affective and cognitive control circuits, providing crucial insights into the pathophysiological mechanism of ESRD patients.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China under Grant Nos. 81471737, 81473603, 81571640, 81371530, 81501543, 81401478, 81571751, 81470816, and 81301281; and the Fundamental Research Funds for the Central Universities.

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Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi’an, 710071, People’s Republic of China
Junya Mu, Tao Chen, Qianqian Liu & Jixin Liu
Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, Xi’an, 710126, People’s Republic of China
Junya Mu, Tao Chen, Qianqian Liu & Jixin Liu
Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, No. 277, West Yanta Road, Xi’an, 710061, Shaanxi-Province, People’s Republic of China
Dun Ding, Xueying Ma, Peng Li, Anmao Li & Ming Zhang
Xi’an Children’s Hospital, Xi’an, 710061, People’s Republic of China
Anmao Li, Mingxia Huang & Zengjun Zhang

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Junya Mu
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Tao Chen
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Qianqian Liu
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Dun Ding
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Xueying Ma
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Peng Li
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Anmao Li
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Mingxia Huang
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Zengjun Zhang
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Jixin Liu
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Ming Zhang
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Junya Mu, Qianqian Liu, Tao Chen, Dun Ding, Xueying Ma, Peng Li, Anmao Li, Mingxia Huang, Zengjun Zhang, Jixin Liu, and Ming Zhang declare that they have no conflict of interest.

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Mu, J., Chen, T., Liu, Q. et al. Abnormal interaction between cognitive control network and affective network in patients with end-stage renal disease. Brain Imaging and Behavior 12, 1099–1111 (2018). https://doi.org/10.1007/s11682-017-9782-z

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Published: 23 October 2017
Issue Date: August 2018
DOI: https://doi.org/10.1007/s11682-017-9782-z

Keywords

End-stage renal disease
Functional magnetic resonance imaging
Cognitive control
Affective
Interaction