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Activations in gray and white matter are modulated by uni-manual responses during within and inter-hemispheric transfer: effects of response hand and right-handedness

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An Erratum to this article was published on 22 September 2017

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Abstract

Because the visual cortices are contra-laterally organized, inter-hemispheric transfer tasks have been used to behaviorally probe how information briefly presented to one hemisphere of the visual cortex is integrated with responses resulting from the ipsi- or contra-lateral motor cortex. By forcing rapid information exchange across diverse regions, these tasks robustly activate not only gray matter regions, but also white matter tracts. It is likely that the response hand itself (dominant or non-dominant) modulates gray and white matter activations during within and inter-hemispheric transfer. Yet the role of uni-manual responses and/or right hand dominance in modulating brain activations during such basic tasks is unclear. Here we investigated how uni-manual responses with either hand modulated activations during a basic visuo-motor task (the established Poffenberger paradigm) alternating between inter- and within-hemispheric transfer conditions. In a large sample of strongly right-handed adults (n = 49), we used a factorial combination of transfer condition [Inter vs. Within] and response hand [Dominant(Right) vs. Non-Dominant (Left)] to discover fMRI-based activations in gray matter, and in narrowly defined white matter tracts. These tracts were identified using a priori probabilistic white matter atlases. Uni-manual responses with the right hand strongly modulated activations in gray matter, and notably in white matter. Furthermore, when responding with the left hand, activations during inter-hemispheric transfer were strongly predicted by the degree of right-hand dominance, with increased right-handedness predicting decreased fMRI activation. Finally, increasing age within the middle-aged sample was associated with a decrease in activations. These results provide novel evidence of complex relationships between uni-manual responses in right-handed subjects, and activations during within- and inter-hemispheric transfer suggest that the organization of the motor system exerts sophisticated functional effects. Moreover, our evidence of activation in white matter tracts is consistent with prior studies, confirming fMRI-detectable white matter activations which are systematically modulated by experimental condition.

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Change history

  • 22 September 2017

    The original version of this article unfortunately contained a mistake. The family name of Paolo Brambilla was incorrectly spelled as Bambilla.

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Acknowledgements

This study was partly supported from grants from Fondazione CariVerona (Obiettivo di ricerca A9 del progetto di Neuroscience "Disabilità cognitiva e comportamentale nelle demenze e nelle psicosi”) to PB and MR and from the Ministry of Health to PB (GR-2010-2319022), and MB (GR-2010-2316745). VAD was supported by a Cooperint Visiting Professorship from the University of Verona, a Career Development Chair from Wayne State University, the Thomas Gershenson Distinguished Faculty Fellowship from Wayne State University, the Lyckaki-Young Fund from the State of Michigan, the Prechter Family Bipolar Foundation, the Children’s Hospital of Michigan Foundation, the Cohen Neuroscience Endowmentand the National Institute of Mental Health (MH111177). We thank Alberto Beltramello for helping in MRI acquisition and data management. The work constitutes a collaborative effort between VAD and PB. Their authorship order is inter-changeable.

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Authors and Affiliations

  1. Brain Imaging Research Division, Department of Psychiatry & Behavioral Neurosciences, Wayne State University School of Medicine, Suite 5B, 3901 Chrysler Drive, Detroit, MI, 48201, USA

    Vaibhav A. Diwadkar & Asadur Chowdury

  2. Department of Public Health and Community Medicine, Section of Psychiatry and Section of Clinical Psychology, University of Verona, 37129, Verona, Italy

    Marcella Bellani, Cinzia Perlini, Veronica Marinelli, Gianluca Rambaldelli & Mirella Ruggieri

  3. Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

    Silvia Savazzi & Carlo A. Marzi

  4. National Institute of Neuroscience-Verona, Verona, Italy

    Silvia Savazzi & Carlo A. Marzi

  5. Neuroradiology Department, Azienda Ospedaliera Universitaria Integrata di Verona, 37126, Verona, Italy

    Giada Zoccatelli, Franco Alessandrini & Elisa Ciceri

  6. Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy

    A. Carlo Altamura & Paolo Brambilla

  7. Department of Psychiatry and Behavioral Neurosciences, University of Texas at Houston, Houston, TX, USA

    Paolo Brambilla

Authors
  1. Vaibhav A. Diwadkar
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  2. Marcella Bellani
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  3. Asadur Chowdury
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  4. Silvia Savazzi
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  5. Cinzia Perlini
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  6. Veronica Marinelli
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  7. Giada Zoccatelli
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  8. Franco Alessandrini
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  9. Elisa Ciceri
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  10. Gianluca Rambaldelli
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  11. Mirella Ruggieri
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  12. A. Carlo Altamura
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  13. Carlo A. Marzi
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  14. Paolo Brambilla
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Corresponding author

Correspondence to Vaibhav A. Diwadkar.

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The authors have no conflicts of interest to report.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.

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The original version of this article was revised: The family name of Paolo Brambilla was corrected

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Diwadkar, V.A., Bellani, M., Chowdury, A. et al. Activations in gray and white matter are modulated by uni-manual responses during within and inter-hemispheric transfer: effects of response hand and right-handedness. Brain Imaging and Behavior 12, 942–961 (2018). https://doi.org/10.1007/s11682-017-9750-7

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  • DOI: https://doi.org/10.1007/s11682-017-9750-7

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