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Brain Imaging and Behavior

, Volume 12, Issue 2, pp 499–508 | Cite as

Impaired engagement of the ventral attention system in neurofibromatosis type 1

  • Natalie A. Pride
  • Mayuresh S. Korgaonkar
  • Kathryn N. North
  • Jonathan M. Payne
Original Research

Abstract

Individuals with neurofibromatosis type 1 (NF1) exhibit significant impairments in attention across multiple domains. Very little is known about the contributing neural networks. We used task-based functional magnetic resonance imaging (fMRI) to examine dorsal and ventral attention networks during auditory oddball processing in children and adolescents with NF1 and typically developing controls. Significant differences in neural activation patterns were identified within brain regions supporting the ventral attention system. Children with NF1 demonstrated hypoactivation in the temporoparietal junction and the anterior cingulate cortex compared to typically developing children. Hypoactivation in the anterior cingulate cortex was associated with poorer selective attention and attentional control in children with NF1. Results indicate an abnormality in bottom-up attention networks in NF1 that may lead to inefficient and faulty suppression of stimulus-driven information outside the current attentional set that play a significant role in the NF1 behavioral phenotype.

Keywords

Neurofibromatosis 1 fMRI Attention Auditory oddball 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11682_2017_9717_MOESM1_ESM.pdf (220 kb)
ESM 1 (PDF 220 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Natalie A. Pride
    • 1
  • Mayuresh S. Korgaonkar
    • 2
    • 3
  • Kathryn N. North
    • 1
    • 4
    • 5
  • Jonathan M. Payne
    • 1
    • 4
    • 5
  1. 1.Institute for Neuroscience and Muscle ResearchThe Children’s Hospital at WestmeadWestmeadAustralia
  2. 2.Brain Dynamics CentreWestmead Institute for Medical ResearchSydneyAustralia
  3. 3.University of Sydney Medical SchoolSydneyAustralia
  4. 4.Murdoch Childrens Research InstituteThe Royal Children’s HospitalMelbourneAustralia
  5. 5.Department of PaediatricsUniversity of MelbourneMelbourneAustralia

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