Brain Imaging and Behavior

, Volume 12, Issue 2, pp 309–323 | Cite as

Structural connectivity in spatial attention network: reconstruction from left hemispatial neglect

  • Takaaki Hattori
  • Kenji Ito
  • Chika Nakazawa
  • Yoshiyuki Numasawa
  • Mayumi Watanabe
  • Shigeki Aoki
  • Hidehiro Mizusawa
  • Sumio Ishiai
  • Takanori Yokota
Original Research


Left hemispatial neglect (neglect) is an impaired state of spatial attention. We aimed to reconstruct structural connectivity in the spatial attention network and to identify disconnection patterns underlying neglect. We enrolled 59 right-handed patients who had their first-ever infarction in the right hemisphere and classified them into neglect group (34 patients with neglect) and control group (25 patients without neglect). The neglect group was further subcategorized into 6 subgroups based on infarcted vascular territories. Diffusion tensor imaging data were obtained from all patients. Fractional anisotropy maps were compared between neglect group/subgroups and the control group by using non-parametric voxel-based analysis, generating a lesion path mask. Probabilistic tractography analysis using the lesion path mask reconstructed the following structural connectivity in the spatial attention network, which is specifically damaged in neglect patients: (1) superior longitudinal fasciculus (SLF) I connecting the superior parietal lobule/intraparietal sulcus with the superior frontal gyrus/frontal eye field (SFG/FEF) (dorsal attention network); (2) SLF III/the arcuate fasciculus (AF) and the extreme capsule/inferior fronto-occipital fasciculus (IFOF) connecting the right inferior parietal lobule/temporoparietal junction/superior temporal gyrus (IPL/TPJ/STG) with the middle frontal gyrus/inferior frontal gyrus (ventral attention network); (3) the thalamic radiations to the spatial attention-related cortices; and (4) SLF II and IFOF interconnecting dorsal and ventral attention networks. Individual analysis indicated that isolated damage in SLF I, SLF II, SLF III/AF or the thalamic radiations to IPL/TPJ/STG due to posterior cerebral artery infarction, or simultaneous damage in four thalamic radiations due to anterior choroidal artery infarction, underlies different phenotypes of neglect.


Left hemispatial neglect Diffusion tensor imaging Structural connectivity 



We would like to thank Devera G. Schoenberg, M.Sc. Editor and the NIH Fellows Editorial Board, for reviewing the manuscript.

Compliance with ethical standards


This study was supported by Comprehensive Brain Science Network, Japan.

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

11682_2017_9698_MOESM1_ESM.docx (20 kb)
Supplementary Table 1 (DOCX 19 kb)
11682_2017_9698_MOESM2_ESM.docx (24 kb)
Supplementary Table 2 (DOCX 24 kb)


  1. Andersen, S. M., Rapcsak, S. Z., & Beeson, P. M. (2010). Cost function masking during normalization of brains with focal lesions: Still a necessity? NeuroImage, 53(1), 78–84.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Asanuma, C., Andersen, R. A., & Cowan, W. M. (1985). The thalamic relations of the caudal inferior parietal lobule and the lateral prefrontal cortex in monkeys: Divergent cortical projections from cell clusters in the medial pulvinar nucleus. The Journal of Comparative Neurology, 241(3), 357–381.CrossRefPubMedGoogle Scholar
  3. Astafiev, S. V., Shulman, G. L., & Corbetta, M. (2006). Visuospatial reorienting signals in the human temporo-parietal junction are independent of response selection. The European Journal of Neuroscience, 23(2), 591–596.CrossRefPubMedGoogle Scholar
  4. Azouvi, P., Olivier, S., de Montety, G., Samuel, C., Louis-Dreyfus, A., & Tesio, L. (2003). Behavioral assessment of unilateral neglect: study of the psychometric properties of the Catherine Bergego scale. Archives of Physical Medicine and Rehabilitation, 84(1), 51–57.CrossRefPubMedGoogle Scholar
  5. Bartolomeo, P., Thiebaut de Schotten, M., & Doricchi, F. (2007). Left unilateral neglect as a disconnection syndrome. Cerebral Cortex, 17(11), 2479–2490.CrossRefPubMedGoogle Scholar
  6. Behrens, T. E., Johansen-Berg, H., Woolrich, M. W., Smith, S. M., Wheeler-Kingshott, C. A., Boulby, P. A., et al. (2003). Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nature Neuroscience, 6(7), 750–757.CrossRefPubMedGoogle Scholar
  7. Behrens, T. E., Berg, H. J., Jbabdi, S., Rushworth, M. F., & Woolrich, M. W. (2007). Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? NeuroImage, 34(1), 144–155.CrossRefPubMedGoogle Scholar
  8. Bird, C. M., Malhotra, P., Parton, A., Coulthard, E., Rushworth, M. F., & Husain, M. (2006). Visual neglect after right posterior cerebral artery infarction. Journal of Neurology, Neurosurgery, and Psychiatry, 77(9), 1008–1012.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Bisiach, E., Geminiani, G., Berti, A., & Rusconi, M. L. (1990). Perceptual and premotor factors of unilateral neglect. Neurology, 40(8), 1278–1281.CrossRefPubMedGoogle Scholar
  10. Bogousslavsky, J., Miklossy, J., Regli, F., Deruaz, J. P., Assal, G., & Delaloye, B. (1988). Subcortical neglect: neuropsychological, SPECT, and neuropathological correlations with anterior choroidal artery territory infarction. Annals of Neurology, 23(5), 448–452.CrossRefPubMedGoogle Scholar
  11. Bourgeois, A., Chica, A. B., Migliaccio, R., Bayle, D. J., Duret, C., Pradat-Diehl, P., et al. (2015). Inappropriate rightward saccades after right hemisphere damage: oculomotor analysis and anatomical correlates. Neuropsychologia, 73, 1–11.CrossRefPubMedGoogle Scholar
  12. Budisavljevic, S., Dell'Acqua, F., Zanatto, D., Begliomini, C., Miotto, D., Motta, R., et al. (2016). Asymmetry and structure of the fronto-parietal networks underlie Visuomotor processing in humans. Cereb Cortex. doi: 10.1093/cercor/bhv348.
  13. Catani, M., Howard, R. J., Pajevic, S., & Jones, D. K. (2002). Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage, 17(1), 77–94.CrossRefPubMedGoogle Scholar
  14. Caverzasi, E., Papinutto, N., Amirbekian, B., Berger, M. S., & Henry, R. G. (2014). Q-ball of inferior fronto-occipital fasciculus and beyond. PloS One, 9(6), e100274.CrossRefPubMedPubMedCentralGoogle Scholar
  15. Chechlacz, M., Rotshtein, P., Bickerton, W. L., Hansen, P. C., Deb, S., & Humphreys, G. W. (2010). Separating neural correlates of allocentric and egocentric neglect: distinct cortical sites and common white matter disconnections. Cognitive Neuropsychology, 27(3), 277–303.CrossRefPubMedGoogle Scholar
  16. Chechlacz, M., Rotshtein, P., Roberts, K. L., Bickerton, W. L., Lau, J. K., & Humphreys, G. W. (2012). The prognosis of allocentric and egocentric neglect: evidence from clinical scans. PloS One, 7(11), e47821.CrossRefPubMedPubMedCentralGoogle Scholar
  17. Committeri, G., Pitzalis, S., Galati, G., Patria, F., Pelle, G., Sabatini, U., et al. (2007). Neural bases of personal and extrapersonal neglect in humans. Brain, 130(Pt 2), 431–441.CrossRefPubMedGoogle Scholar
  18. Corbetta, M., & Shulman, G. L. (2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews. Neuroscience, 3(3), 201–215.CrossRefPubMedGoogle Scholar
  19. Corbetta, M., & Shulman, G. L. (2011). Spatial neglect and attention networks. Annual Review of Neuroscience, 34, 569–599.CrossRefPubMedPubMedCentralGoogle Scholar
  20. Corbetta, M., Kincade, J. M., Ollinger, J. M., McAvoy, M. P., & Shulman, G. L. (2000). Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nature Neuroscience, 3(3), 292–297.CrossRefPubMedGoogle Scholar
  21. Corbetta, M., Kincade, M. J., Lewis, C., Snyder, A. Z., & Sapir, A. (2005). Neural basis and recovery of spatial attention deficits in spatial neglect. Nature Neuroscience, 8(11), 1603–1610.CrossRefPubMedGoogle Scholar
  22. Dick, A. S., & Tremblay, P. (2012). Beyond the arcuate fasciculus: consensus and controversy in the connectional anatomy of language. Brain, 135(Pt 12), 3529–3550.CrossRefPubMedGoogle Scholar
  23. Doricchi, F., & Tomaiuolo, F. (2003). The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? Neuroreport, 14(17), 2239–2243.CrossRefPubMedGoogle Scholar
  24. Downar, J., Crawley, A. P., Mikulis, D. J., & Davis, K. D. (2000). A multimodal cortical network for the detection of changes in the sensory environment. Nature Neuroscience, 3(3), 277–283.CrossRefPubMedGoogle Scholar
  25. Ferro, J. M., & Kertesz, A. (1984). Posterior internal capsule infarction associated with neglect. Archives of Neurology, 41(4), 422–424.CrossRefPubMedGoogle Scholar
  26. Fox, M. D., Corbetta, M., Snyder, A. Z., Vincent, J. L., & Raichle, M. E. (2006). Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proceedings of the National Academy of Sciences of the United States of America, 103(26), 10046–10051.CrossRefPubMedPubMedCentralGoogle Scholar
  27. Gillebert, C. R., Mantini, D., Thijs, V., Sunaert, S., Dupont, P., & Vandenberghe, R. (2011). Lesion evidence for the critical role of the intraparietal sulcus in spatial attention. Brain, 134(Pt 6), 1694–1709.CrossRefPubMedGoogle Scholar
  28. He, B. J., Snyder, A. Z., Vincent, J. L., Epstein, A., Shulman, G. L., & Corbetta, M. (2007). Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect. Neuron, 53(6), 905–918.CrossRefPubMedGoogle Scholar
  29. Husain, M., & Kennard, C. (1996). Visual neglect associated with frontal lobe infarction. Journal of Neurology, 243(9), 652–657.CrossRefPubMedGoogle Scholar
  30. Ishiai, S. (1999). Behavioral inattention test (Japanese ed.). Tokyo: Shinkoh Igaku Shuppan.Google Scholar
  31. Kamishina, H., Yurcisin, G. H., Corwin, J. V., & Reep, R. L. (2008). Striatal projections from the rat lateral posterior thalamic nucleus. Brain Research, 1204, 24–39.CrossRefPubMedGoogle Scholar
  32. Karnath, H. O., Himmelbach, M., & Rorden, C. (2002). The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain, 125(Pt 2), 350–360.CrossRefPubMedGoogle Scholar
  33. Karnath, H. O., Fruhmann Berger, M., Kuker, W., & Rorden, C. (2004). The anatomy of spatial neglect based on voxelwise statistical analysis: a study of 140 patients. Cerebral Cortex, 14(10), 1164–1172.CrossRefPubMedGoogle Scholar
  34. Karnath, H. O., Rennig, J., Johannsen, L., & Rorden, C. (2011). The anatomy underlying acute versus chronic spatial neglect: a longitudinal study. Brain, 134(Pt 3), 903–912.CrossRefPubMedGoogle Scholar
  35. Kinsbourne, M. (1977). Hemi-neglect and hemisphere rivalry. Advances in Neurology, 18, 41–49.PubMedGoogle Scholar
  36. Kucyi, A., Moayedi, M., Weissman-Fogel, I., Hodaie, M., & Davis, K. D. (2012). Hemispheric asymmetry in white matter connectivity of the temporoparietal junction with the insula and prefrontal cortex. PloS One, 7(4), e35589.CrossRefPubMedPubMedCentralGoogle Scholar
  37. Leh, S. E., Johansen-Berg, H., & Ptito, A. (2006). Unconscious vision: New insights into the neuronal correlate of blindsight using diffusion tractography. Brain, 129(Pt 7), 1822–1832.CrossRefPubMedGoogle Scholar
  38. Leibovitch, F. S., Black, S. E., Caldwell, C. B., Ebert, P. L., Ehrlich, L. E., & Szalai, J. P. (1998). Brain-behavior correlations in hemispatial neglect using CT and SPECT: the Sunnybrook stroke study. Neurology, 50(4), 901–908.CrossRefPubMedGoogle Scholar
  39. Lunven, M., Thiebaut De Schotten, M., Bourlon, C., Duret, C., Migliaccio, R., Rode, G., et al. (2015). White matter lesional predictors of chronic visual neglect: a longitudinal study. Brain, 138(Pt 3), 746–760.CrossRefPubMedPubMedCentralGoogle Scholar
  40. Martino, J., Brogna, C., Robles, S. G., Vergani, F., & Duffau, H. (2010). Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data. Cortex, 46(5), 691–699.CrossRefPubMedGoogle Scholar
  41. Mesulam, M. M. (1981). A cortical network for directed attention and unilateral neglect. Annals of Neurology, 10(4), 309–325.CrossRefPubMedGoogle Scholar
  42. Mesulam, M. M. (1999). Spatial attention and neglect: parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 354(1387), 1325–1346.CrossRefPubMedPubMedCentralGoogle Scholar
  43. Mort, D. J., Malhotra, P., Mannan, S. K., Rorden, C., Pambakian, A., Kennard, C., et al. (2003). The anatomy of visual neglect. Brain, 126(Pt 9), 1986–1997.CrossRefPubMedGoogle Scholar
  44. Mukherjee, P. (2005). Diffusion tensor imaging and fiber tractography in acute stroke. Neuroimaging Clinics of North America, 15(3), 655–665 xii.CrossRefPubMedGoogle Scholar
  45. Neggers, S. F., Van der Lubbe, R. H., Ramsey, N. F., & Postma, A. (2006). Interactions between ego- and allocentric neuronal representations of space. NeuroImage, 31(1), 320–331.CrossRefPubMedGoogle Scholar
  46. Ota, H., Fujii, T., Tabuchi, M., Sato, K., Saito, J., & Yamadori, A. (2003). Different spatial processing for stimulus-centered and body-centered representations. Neurology, 60(11), 1846–1848.CrossRefPubMedGoogle Scholar
  47. Park, K. C., Lee, B. H., Kim, E. J., Shin, M. H., Choi, K. M., Yoon, S. S., et al. (2006). Deafferentation-disconnection neglect induced by posterior cerebral artery infarction. Neurology, 66(1), 56–61.CrossRefPubMedGoogle Scholar
  48. Petrides, M., & Pandya, D. N. (2002). Comparative cytoarchitectonic analysis of the human and the macaque ventrolateral prefrontal cortex and corticocortical connection patterns in the monkey. The European Journal of Neuroscience, 16(2), 291–310.CrossRefPubMedGoogle Scholar
  49. Ptak, R., & Schnider, A. (2010). The dorsal attention network mediates orienting toward behaviorally relevant stimuli in spatial neglect. The Journal of Neuroscience, 30(38), 12557–12565.CrossRefPubMedGoogle Scholar
  50. Rafal, R. D., & Posner, M. I. (1987). Deficits in human visual spatial attention following thalamic lesions. Proceedings of the National Academy of Sciences of the United States of America, 84(20), 7349–7353.CrossRefPubMedPubMedCentralGoogle Scholar
  51. Rengachary, J., He, B. J., Shulman, G. L., & Corbetta, M. (2011). A behavioral analysis of spatial neglect and its recovery after stroke. Frontiers in Human Neuroscience, 5, 29.CrossRefPubMedPubMedCentralGoogle Scholar
  52. Ringman, J. M., Saver, J. L., Woolson, R. F., Clarke, W. R., & Adams, H. P. (2004). Frequency, risk factors, anatomy, and course of unilateral neglect in an acute stroke cohort. Neurology, 63(3), 468–474.CrossRefPubMedGoogle Scholar
  53. Rorden, C., & Brett, M. (2000). Stereotaxic display of brain lesions. Behavioural Neurology, 12(4), 191–200.CrossRefPubMedGoogle Scholar
  54. Rushworth, M. F., Behrens, T. E., & Johansen-Berg, H. (2006). Connection patterns distinguish 3 regions of human parietal cortex. Cerebral Cortex, 16(10), 1418–1430.CrossRefPubMedGoogle Scholar
  55. Sarubbo, S., De Benedictis, A., Maldonado, I. L., Basso, G., & Duffau, H. (2013). Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle. Brain Structure & Function, 218(1), 21–37.CrossRefGoogle Scholar
  56. Schmahmann, J. D. (2003). Vascular syndromes of the thalamus. Stroke, 34(9), 2264–2278.CrossRefPubMedGoogle Scholar
  57. Schmahmann, J. D., & Pandya, D. N. (2007). The complex history of the fronto-occipital fasciculus. Journal of the History of the Neurosciences, 16(4), 362–377.CrossRefPubMedGoogle Scholar
  58. Schmahmann, J. D., Pandya, D. N., Wang, R., Dai, G., D'Arceuil, H. E., de Crespigny, A. J., et al. (2007). Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. Brain, 130(Pt 3), 630–653.CrossRefPubMedGoogle Scholar
  59. Shomstein, S., Lee, J., & Behrmann, M. (2010). Top-down and bottom-up attentional guidance: investigating the role of the dorsal and ventral parietal cortices. Experimental Brain Research, 206(2), 197–208.CrossRefPubMedPubMedCentralGoogle Scholar
  60. Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E., Johansen-Berg, H., et al. (2004). Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage, 23(Suppl 1), S208–S219.CrossRefPubMedGoogle Scholar
  61. Thiebaut de Schotten, M., Urbanski, M., Duffau, H., Volle, E., Levy, R., Dubois, B., et al. (2005). Direct evidence for a parietal-frontal pathway subserving spatial awareness in humans. Science, 309(5744), 2226–2228.CrossRefPubMedGoogle Scholar
  62. Thiebaut de Schotten, M., Dell'Acqua, F., Forkel, S. J., Simmons, A., Vergani, F., Murphy, D. G., et al. (2011). A lateralized brain network for visuospatial attention. Nature Neuroscience, 14(10), 1245–1246.CrossRefPubMedGoogle Scholar
  63. Thiebaut de Schotten, M., Tomaiuolo, F., Aiello, M., Merola, S., Silvetti, M., Lecce, F., et al. (2014). Damage to white matter pathways in subacute and chronic spatial neglect: a group study and 2 single-case studies with complete virtual "in vivo" tractography dissection. Cerebral Cortex, 24(3), 691–706.CrossRefPubMedGoogle Scholar
  64. Thompson, K. G., Biscoe, K. L., & Sato, T. R. (2005). Neuronal basis of covert spatial attention in the frontal eye field. The Journal of Neuroscience, 25(41), 9479–9487.CrossRefPubMedPubMedCentralGoogle Scholar
  65. Umarova, R. M., Saur, D., Schnell, S., Kaller, C. P., Vry, M. S., Glauche, V., et al. (2010). Structural connectivity for visuospatial attention: significance of ventral pathways. Cerebral Cortex, 20(1), 121–129.CrossRefPubMedGoogle Scholar
  66. Urbanski, M., Thiebaut de Schotten, M., Rodrigo, S., Catani, M., Oppenheim, C., Touze, E., et al. (2008). Brain networks of spatial awareness: evidence from diffusion tensor imaging tractography. Journal of Neurology, Neurosurgery, and Psychiatry, 79(5), 598–601.CrossRefPubMedGoogle Scholar
  67. Urbanski, M., Thiebaut de Schotten, M., Rodrigo, S., Oppenheim, C., Touze, E., Meder, J. F., et al. (2011). DTI-MR tractography of white matter damage in stroke patients with neglect. Experimental Brain Research, 208(4), 491–505.CrossRefPubMedGoogle Scholar
  68. Vallar, G. (2001). Extrapersonal visual unilateral spatial neglect and its neuroanatomy. NeuroImage, 14(1 Pt 2), S52–S58.CrossRefPubMedGoogle Scholar
  69. Vallar, G., Bello, L., Bricolo, E., Castellano, A., Casarotti, A., Falini, A., et al. (2014). Cerebral correlates of visuospatial neglect: A direct cerebral stimulation study. Human Brain Mapping, 35(4), 1334–1350.CrossRefPubMedGoogle Scholar
  70. Vandenberghe, R., Molenberghs, P., & Gillebert, C. R. (2012). Spatial attention deficits in humans: the critical role of superior compared to inferior parietal lesions. Neuropsychologia, 50(6), 1092–1103.CrossRefPubMedGoogle Scholar
  71. Vargas, M. E., & Barres, B. A. (2007). Why is Wallerian degeneration in the CNS so slow? Annual Review of Neuroscience, 30, 153–179.CrossRefPubMedGoogle Scholar
  72. Verdon, V., Schwartz, S., Lovblad, K. O., Hauert, C. A., & Vuilleumier, P. (2010). Neuroanatomy of hemispatial neglect and its functional components: a study using voxel-based lesion-symptom mapping. Brain, 133(Pt 3), 880–894.CrossRefPubMedGoogle Scholar
  73. Vernet, M., Quentin, R., Chanes, L., Mitsumasu, A., & Valero-Cabre, A. (2014). Frontal eye field, where art thou? Anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations. Frontiers in Integrative Neuroscience, 8, 66.PubMedPubMedCentralGoogle Scholar
  74. Wardak, C., Olivier, E., & Duhamel, J. R. (2004). A deficit in covert attention after parietal cortex inactivation in the monkey. Neuron, 42(3), 501–508.CrossRefPubMedGoogle Scholar
  75. Watson, R. T., & Heilman, K. M. (1979). Thalamic neglect. Neurology, 29(5), 690–694.CrossRefPubMedGoogle Scholar
  76. Weber, J. T., & Yin, T. C. (1984). Subcortical projections of the inferior parietal cortex (area 7) in the stump-tailed monkey. The Journal of Comparative Neurology, 224(2), 206–230.CrossRefPubMedGoogle Scholar
  77. Winkler, A. M., Ridgway, G. R., Webster, M. A., Smith, S. M., & Nichols, T. E. (2014). Permutation inference for the general linear model. NeuroImage, 92, 381–397.CrossRefPubMedPubMedCentralGoogle Scholar
  78. Yeterian, E. H., & Pandya, D. N. (1989). Thalamic connections of the cortex of the superior temporal sulcus in the rhesus monkey. The Journal of Comparative Neurology, 282(1), 80–97.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Takaaki Hattori
    • 1
  • Kenji Ito
    • 2
  • Chika Nakazawa
    • 3
  • Yoshiyuki Numasawa
    • 1
  • Mayumi Watanabe
    • 3
  • Shigeki Aoki
    • 4
  • Hidehiro Mizusawa
    • 5
  • Sumio Ishiai
    • 6
  • Takanori Yokota
    • 1
  1. 1.Department of Neurology and Neurological ScienceTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Division of Ultra-High Field MRI, Institute for Biomedical SciencesIwate Medical UniversityIwateJapan
  3. 3.Department of RehabilitationJA Toride Medical CenterIbarakiJapan
  4. 4.Department of RadiologyJuntendo UniversityTokyoJapan
  5. 5.National Center of Neurology and PsychiatryTokyoJapan
  6. 6.Department for RehabilitationSapporo Medical UniversitySapporoJapan

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