Brain functional connectivity in lung cancer population: an exploratory study
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The present study aimed to explore the functional connectivity differences in Resting State Networks (RSNs) induced by cancer and chemotherapy in Lung Cancer (LC) patients using an Independent Component Analysis (ICA). Three matched groups of 15 LC patients following Chemotherapy (C+), 15 LC patients before Chemotherapy (C-) and 15 Healthy Controls (HC) were included. Analysis was performed using ICA and a multivariate pattern analysis (MVPA) to classify groups based on profiles of functional connectivity. We found significant differences in four of the RSN identified: Default Mode Network (DMN), Predominantly Left and Right Anterior Temporal Network, and Cerebellum Network. Whereas DMN showed decreased connectivity, the other RSNs exhibited increased connectivity in both LC groups compared to HC and in C+ in comparison to C-. MVPA discriminated significantly and accurately between all groups. Our study showed that disrupted functional connectivity associated with cancer and chemotherapy-induced cognitive deficits is not only related to DMN decreased connectivity abnormalities but also to an increased connectivity of other RSNs, suggesting a potential compensatory mechanism.
KeywordsResting-state functional magnetic resonance imaging Chemotherapy Lung cancer Default mode network Functional connectivity
Compliance with ethical standards
This work was supported by la Fundació Marató-TV3 [Acquired Spinal Cord and Brain Injuries Program (2012–2015) awarded to ARF] and Hospital of Bellvitge Research Award 2016. Marta Simó is a recipient of a Juan Rodés contract from the Carlos III National Health Institute (Spanish Government)- European Social Fund (ESF).
Conflicts of interest
All the signing authors have seen and approved the manuscript content and there is no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.
Informed consent was obtained from all individual participants included in the study.
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