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Gray matter volume and dual-task gait performance in mild cognitive impairment

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Abstract

Dual-task gait performance is impaired in older adults with mild cognitive impairment, but the brain substrates associated with dual-task gait performance are not well-established. The relationship between gray matter and gait speed under single-task and dual-task conditions (walking while counting backward) was examined in 560 seniors with mild cognitive impairment (non-amnestic mild cognitive impairment: n = 270; mean age = 72.4 yrs., 63.6 % women; amnestic mild cognitive impairment: n = 290; mean age = 73.4 yrs., 45.4 % women). Multivariate covariance-based analyses of magnetic resonance imaging data, adjusted for potential confounders including single-task gait speed, were performed to identify gray matter patterns associated with dual-task gait speed. There were no differences in gait speed or cognitive performance during dual-task gait between individuals with non-amnestic mild cognitive impairment and amnestic mild cognitive impairment. Overall, increased dual-task gait speed was associated with a gray matter pattern of increased volume in medial frontal gyrus, superior frontal gyrus, anterior cingulate, cingulate, precuneus, fusiform gyrus, middle occipital gyrus, inferior temporal gyrus and middle temporal gyrus. The relationship between dual-task gait speed and brain substrates also differed by mild cognitive impairment subtype. Our study revealed a pattern of gray matter regions associated with dual-task performance. Although dual-task gait performance was similar in amnestic and non-amnestic mild cognitive impairment, the gray matter patterns associated with dual-task gait performance differed by mild cognitive impairment subtype. These findings suggest that the brain substrates supporting dual-task gait performance in amnestic and non-amnestic subtypes are different, and consequently may respond differently to interventions, or require different interventions.

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Acknowledgments

We thank the Obu and Nagoya city offices for help with participant recruitment.

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Authors and Affiliations

  1. Department of Preventive Gerontology, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, Japan

    Takehiko Doi, Hiroyuki Shimada, Hyuma Makizako, Kota Tsutsumimoto, Ryo Hotta & Sho Nakakubo

  2. Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo, Japan

    Takehiko Doi

  3. Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA

    Takehiko Doi, Helena M. Blumen & Joe Verghese

  4. Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA

    Takehiko Doi, Helena M. Blumen & Joe Verghese

  5. National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, 474-8511, Japan

    Takao Suzuki

  6. Graduate School of Gerontology, J.F. Oberlin University, Machida, Tokyo, Japan

    Takao Suzuki

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  1. Takehiko Doi
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Correspondence to Takehiko Doi.

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Funding

This work was supported by Health and Labor Sciences Research Grants (Comprehensive Research on Aging and Health); a Grant-in-Aid for Scientific Research (B) (23300205); a Grant-in-Aid for Young Scientists (A) (15H05369); a Grant-in-Aid for JSPS Fellows (259435); and Research Funding for Longevity Sciences (22–16) from the National Center for Geriatrics and Gerontology, Japan.

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None of the authors have any financial, personal, or potential conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of ethics committee of the National Center for Geriatrics and Gerontology and with the Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study

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Doi, T., Blumen, H.M., Verghese, J. et al. Gray matter volume and dual-task gait performance in mild cognitive impairment. Brain Imaging and Behavior 11, 887–898 (2017). https://doi.org/10.1007/s11682-016-9562-1

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