Aberrant regional homogeneity of resting-state executive control, default mode, and salience networks in adult patients with moyamoya disease
- 235 Downloads
Aberrant local connectivity within cerebral intrinsic connectivity networks (ICNs) at rest has not been reported in adult moyamoya disease (MMD). Our aim was to examine the regional homogeneity (ReHo) of executive control (ECN), default mode (DMN), and salience networks (SN) in patients with executive dysfunction to explore the underlying mechanism. Twenty-six adult patients with MMD and 24 normal control (NC) subjects were recruited. Executive function was evaluated by Trail Making Test Part B (TMT-B) and executive subtests of Memory and Executive Screening (MES-EX). Compared with NC, the case group exhibited ReHo decrease mainly in the frontal and parietal gyrus, and increase only in the left middle temporal gyrus. Subsequent ICNs analysis indicated that compared with NC, patients with MMD exhibited significantly decreased ReHo in the dorsolateral prefrontal cortex (DLPFC) and inferior parietal gyrus (IPG) of left ECN; the IPG, superior frontal gyrus, and DLPFC of the right ECN; the right precuneus, left medial superior frontal gyrus, and right medial orbitofrontal gyrus of the DMN; as well as the left middle frontal gyrus and right supplemental motor area of SN. When referring to the Suzuki’s 6-stage classification, a trend of ReHo decrease with disease severity was observed in all of the ICNs examined, but only bilateral ECNs reached statistical significance. Finally, only bilateral ECNs exhibited a significant correlation of averaged ReHo values with executive performance. Our results provide new insight into the pathophysiology of adult MMD.
KeywordsExecutive function Functional magnetic resonance imaging Moyamoya disease Regional homogeneity
This work is supported by grant 2014CB541604 from the National Key Basic Research Program of China (973 Program) and grant 81371307 from the National Natural Science Foundation of China.
Compliance with ethical standards
All research procedures were approved by the Institutional Ethics Committee of Huashan Hospital of Fudan University, and were conducted in accordance with the 1964 Helsinki declaration and its later amendments. All participants gave written informed consent after totally understanding the purposes of our study.
Conflicts of interest
Yu Lei, Jiabin Su, Hanqiang Jiang, Qihao Guo, Wei Ni, Heng Yang, Yuxiang Gu, and Ying Mao declare that they have no conflicts of interest.
- Calviere, L., Catalaa, I., Marlats, F., Viguier, A., Bonneville, F., Cognard, C., et al. (2010). Correlation between cognitive impairment and cerebral hemodynamic disturbances on perfusion magnetic resonance imaging in European adults with moyamoya disease. Clinical article. Journal of Neurosurgery, 133(4), 753–759.CrossRefGoogle Scholar
- Gorelick, P. B., Scuteri, A., Black, S. E., Decarli, C., Greenberg, S. M., Iadecola, C., et al. (2011). Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American heart association/American stroke association. Stroke, 42(9), 2672–2713.CrossRefPubMedPubMedCentralGoogle Scholar
- Sridharan, D., Levitin, D. J., & Menon, V. (2008). A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proceedings of the National Academy of Sciences of the United States of America, 105(34), 12569–12574.CrossRefPubMedPubMedCentralGoogle Scholar