Altered resting state functional connectivity of anterior insula in young smokers
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The insula has been implicated in cognitive control and craving, all of which are critical to the clinical manifestations of nicotine dependence. However, little evidence exists about the abnormalities in resting state functional connectivity (RSFC) of the insula in young smokers, which might improve our understanding of the neural mechanisms of nicotine dependence. Due to the structural and functional heterogeneity of the insula, the RSFC patterns of both left and right anterior (AI) and posterior insula (PI) were investigated in young smokers and non-smokers. Meanwhile, the relationship was assessed between the neuroimaging findings and clinical information (pack-years, FTND, and craving) as well as cognitive control deficits measured by Stroop task performance. Compared with non-smokers, young smokers showed reduced RSFC between right AI and anterior cingulate cortex (ACC), ventromedial prefrontal cortex (VMPFC), amygdala, left dorsolateral prefrontal cortex, and dorsal striatum. Additionally, left AI showed reduced RSFC with ACC. Both left and right PI network differences were not observed between two groups. Moreover, in young smokers, FTND and incongruent errors in the Stroop task were negatively correlated with the RSFC between AI and ACC. Craving scores showed a significantly negative relationship with the RSFC strength between right AI and left VMPFC. These results provide a more thorough network-level understanding the role of insula in cigarette smoking. The findings provide new insights into the roles of AI-ACC circuit in cognitive control deficits and right AI-VMPFC circuit relevant to the craving of nicotine dependence for young smokers.
KeywordsInsula Resting state functional connectivity Young smokers Cognitive control Craving
This paper is supported by the Project for the National Key Basic Research and Development Program (973) under Grant nos. 2014CB543203, 2011CB707700, 2012CB518501, the National Natural Science Foundation of China under Grant nos. 81571751, 81571753, 61502376, 81401478, 81401488, 81271644, 81271546, 81271549, 81470816, 81471737, 81301281, the Natural Science Basic Research Plan in Shaanxi Province of China under Grant no. 2014JQ4118, and the Fundamental Research Funds for the Central Universities under the Grant nos. JB151204, JB121405, the Natural Science Foundation of Inner Mongolia under Grant no. 2014BS0610, the Innovation Fund Project of Inner Mongolia University of Science and Technology Nos. 2015QNGG03, 2014QDL002, General Financial Grant the China Post- doctoral Science Foundation under Grant no. 2014 M552416.
Compliance with ethical standards
Conflict of interest
Yanzhi Bi, Kai Yuan, Yanyan Guan, Jiadong Cheng, Yajuan Zhang, Yangding Li, Dahua Yu, Wei Qin, Jie Tian declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- Cai, C., Yuan, K., Yin, J., Feng, D., Bi, Y., Li, Y., et al. (2015). Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder. Brain Imaging and Behavior, 1-9. doi: 10.1007/s11682-015-9358-8.
- Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008). Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philosophical Transactions of the Royal Society B: Biological Sciences, 363(1507), 3125–3135.CrossRefGoogle Scholar
- Feng, D., Yuan, K., Li, Y., Cai, C., Yin, J., Bi, Y., Cheng, J., Guan, Y., Shi, S., Yu, D., Jin, C., Lu, X., Qin, W., & Tian, J. (2015). Intra-regional and inter-regional abnormalities and cognitive control deficits in young adult smokers. Brain Imaging and Behavior. doi: 10.1007/s11682-015-9427-z.
- Hanlon, C. A., Owens, M. M., Joseph, J. E., Zhu, X., George, M. S., Brady, K. T., et al. (2014). Lower subcortical gray matter volume in both younger smokers and established smokers relative to non-smokers. Addiction biology. doi: 10.1111/adb.12171.
- Li, X., Hartwell, K. J., Borckardt, J., Prisciandaro, J. J., Saladin, M. E., Morgan, P. S., et al. (2013). Volitional reduction of anterior cingulate cortex activity produces decreased cue craving in smoking cessation: a preliminary real-time fMRI study. Addiction Biology, 18(4), 739–748.CrossRefPubMedGoogle Scholar
- McClernon, F. J., Hiott, F. B., Liu, J., Salley, A. N., Behm, F. M., & Rose, J. E. (2007). IMAGING STUDY: selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study. Addiction Biology, 12(3–4), 503–512.CrossRefPubMedGoogle Scholar
- Sutherland, M. T., Carroll, A. J., Salmeron, B. J., Ross, T. J., Hong, L. E., & Stein, E. A. (2013a). Down-regulation of amygdala and insula functional circuits by varenicline and nicotine in abstinent cigarette smokers. Biological Psychiatry, 74(7), 538–546.CrossRefPubMedPubMedCentralGoogle Scholar
- White, H. R., Bray, B. C., Fleming, C. B., & Catalano, R. F. (2009). Transitions into and out of light and intermittent smoking during emerging adulthood. Nicotine & Tobacco Research, ntn017.Google Scholar
- Yuan, K., Qin, W., Yu, D., Bi, Y., Xing, L., Jin, C., et al. (2015). Core brain networks interactions and cognitive control in internet gaming disorder individuals in late adolescence/early adulthood. Brain Structure and Function, 1-16. doi: 10.1007/s00429-014-0982-7.