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Brain Imaging and Behavior

, Volume 11, Issue 1, pp 1–7 | Cite as

Occipital cortical gyrification reductions associate with decreased functional connectivity in amyotrophic lateral sclerosis

  • Yuanchao Zhang
  • Tao Fang
  • Yue Wang
  • Xin Guo
  • Abdulqawi Alarefi
  • Jian Wang
  • Tianzi Jiang
  • Jiuquan Zhang
Original Research

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscular weakness and atrophy. Several morphometric studies have been conducted to investigate the gray matter volume or thickness changes in ALS, whereas the cortical folding pattern remains poorly understood. In the present study, we applied a surface-based local gyrification index (LGI) from high resolution MRI data to quantify the cortical folding in matched samples of 25 ALS patients versus 25 healthy controls. Using resting-state fMRI data, we further conducted seed-based functional connectivity analysis to explore the functional correlate of the cortical folding changes. We found that ALS patients had significantly reduced LGI in right occipital cortex and that abnormality in this region associated with decreased functional connectivity in the bilateral precuneus. This set of findings was speculated to result from disturbed white matter connectivity in ALS. In the patient group, we revealed significant negative correlations between disease duration and the LGIs of a cluster in the left superior frontal gyrus, which may reflect the cognitive deterioration in ALS. In summary, our results suggest that LGI may provide a useful means to assess ALS-related neurodegeneration and to study the pathophysiology of ALS.

Keywords

Amyotrophic lateral sclerosis Cortical folding Local gyrification index Functional connectivity White matter connectivity 

Notes

Compliance with ethical standards

All procedures performed in this study of human participants were in accordance with the ethical standards of the institutional review board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all the participants. The study was approved by the Medical Research Ethics Committee of Southwest Hospital, The Third Military Medical University, People’s Republic of China.

Conflict of interest

All authors declare that they have no conflict of interest.

Funding

This work was funded by the National Basic Research Program of China (973 program, Grant No. 2011CB707800), the Natural Science Foundation of China (Grant Nos. 81101000), and Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province (Grant No. 2014SZ0014).

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Yuanchao Zhang
    • 1
  • Tao Fang
    • 1
  • Yue Wang
    • 1
  • Xin Guo
    • 1
  • Abdulqawi Alarefi
    • 1
  • Jian Wang
    • 2
  • Tianzi Jiang
    • 1
    • 3
  • Jiuquan Zhang
    • 2
  1. 1.Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduChina
  2. 2.Department of Radiology, Southwest HospitalThird Military Medical UniversityChongqingChina
  3. 3.National Laboratory of Pattern Recognition, Institute of AutomationChinese Academy of SciencesBeijingChina

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