Brain Imaging and Behavior

, Volume 9, Issue 4, pp 910–912 | Cite as

Alice in Wonderland Syndrome associated with a temporo-parietal cavernoma

  • Michelle PhilipEmail author
  • Jeffery Kornitzer
  • David Marks
  • Huey-Jen Lee
  • Nizar Souayah


Alice in Wonderland Syndrome (AIWS) is characterized by a rare constellation of perceptual disturbances including distorted body image, metamorphopsia, and visual hallucinations. In this report, we relate a unique case of AIWS in a woman with a right temporo-parietal cavernoma. AIWS in this patient may be secondary to epileptiform activity associated with the cavernoma and improved with anti-epileptic treatment.


Epilepsy Hallucinations Alice in Wonderland Syndrome Cavernoma 


  1. Damasio, A. R. (1985). Disorders of complex visual processing. In M. M. Mesulam (Ed.), rinciples of Behavioural Neurology. Philadelphia: FA Davis.Google Scholar
  2. Evans, R. W., & Rolak, L. A. (2004). The Alice in Wonderland Syndrome. Headache, 44(6), 624–625. doi: 10.1111/j.1526-4610.2004.446013.x.CrossRefPubMedGoogle Scholar
  3. Gencoglu, E. A., Alehan, F., Erol, I., Koyuncu, A., & Aras, M. (2005). Brain SPECT findings in a patient with Alice in Wonderland syndrome. Clinical Nuclear Medicine, 30(11), 758–759.CrossRefPubMedGoogle Scholar
  4. Grant, A. C., Donnelly, K. M., Chubb, C., Barr, W. B., Kuzniecky, R., & Devinsky, O. (2008). Temporal lobe epilepsy does not impair visual perception. Epilepsia, 49(4), 710–713. doi: 10.1111/j.1528-1167.2007.01483.x.CrossRefPubMedGoogle Scholar
  5. Hauf, M., Wiest, R., Schindler, K., Jann, K., Dierks, T., Strik, W., et al. (2013). Common mechanisms of auditory hallucinations-perfusion studies in epilepsy. Psychiatry Research, 211(3), 268–270. doi: 10.1016/j.pscychresns.2012.06.007.CrossRefPubMedGoogle Scholar
  6. Kassubek, J., Otte, M., Wolter, T., Greenlee, M. W., Mergner, T., & Lucking, C. H. (1999). Brain imaging in a patient with hemimicropsia. Neuropsychologia, 37(12), 1327–1334.CrossRefPubMedGoogle Scholar
  7. Kuo, Y. T., Chiu, N. C., Shen, E. Y., Ho, C. S., & Wu, M. C. (1998). Cerebral perfusion in children with Alice in Wonderland syndrome. Pediatric Neurology, 19(2), 105–108.CrossRefPubMedGoogle Scholar
  8. Mocellin, R., Walterfang, M., & Velakoulis, D. (2006). Neuropsychiatry of complex visual hallucinations. The Australian and New Zealand Journal of Psychiatry, 40, 742–751.CrossRefPubMedGoogle Scholar
  9. Shahani, L. (2013). Complex visual hallucinations associated with parietal infarct. Journal of Neuropsychiatry and Clinical Neurosciences, 25(1), E29.CrossRefPubMedGoogle Scholar
  10. Sommer, I., Diederen, K., Blom, J., Willems, A., Kushan, L., Slotema, K., et al. (2008). Complex auditory and verbal hallucinations predominantly activate the right inferior frontal area. Brain, 131(3), 169–3177.Google Scholar
  11. Todd, J. (1955). The syndrome of Alice in Wonderland. Canadian Medical Association Journal, 73(9), 701–704.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Michelle Philip
    • 1
    Email author
  • Jeffery Kornitzer
    • 1
  • David Marks
    • 1
  • Huey-Jen Lee
    • 2
  • Nizar Souayah
    • 1
  1. 1.Department of Neurology and NeurosciencesRutgers-New Jersey Medical SchoolNewarkUSA
  2. 2.Department of RadiologyRutgers-New Jersey Medical SchoolNewarkUSA

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