Brain Imaging and Behavior

, Volume 5, Issue 4, pp 285–294

Investigation of amygdala volume in men with the fragile X premutation

  • Diana Selmeczy
  • Kami Koldewyn
  • John M. Wang
  • Aaron Lee
  • Danielle Harvey
  • David R. Hessl
  • Flora Tassone
  • Patrick Adams
  • Randi J. Hagerman
  • Paul J. Hagerman
  • Susan M. Rivera
Original Research

Abstract

Premutation fragile X carriers have a CGG repeat expansion (55 to 200 repeats) in the promoter region of the fragile X mental retardation 1 (FMR1) gene. Amygdala dysfunction has been observed in premutation symptomatology, and recent research has suggested the amygdala as an area susceptible to the molecular effects of the premutation. The current study utilizes structural magnetic resonance imaging (MRI) to examine the relationship between amygdala volume, CGG expansion size, FMR1 mRNA, and psychological symptoms in male premutation carriers without FXTAS compared with age and IQ matched controls. No significant between group differences in amygdala volume were found. However, a significant negative correlation between amygdala volume and CGG was found in the lower range of CGG repeat expansions, but not in the higher range of CGG repeat expansions.

Keywords

Fragile X premutation Amygdala FMR1 mRNA Structural MRI 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Diana Selmeczy
    • 1
  • Kami Koldewyn
    • 1
    • 2
  • John M. Wang
    • 1
  • Aaron Lee
    • 2
  • Danielle Harvey
    • 3
  • David R. Hessl
    • 2
    • 4
  • Flora Tassone
    • 2
    • 5
  • Patrick Adams
    • 2
  • Randi J. Hagerman
    • 2
    • 6
  • Paul J. Hagerman
    • 2
    • 5
  • Susan M. Rivera
    • 1
    • 2
    • 7
  1. 1.Center for Mind and BrainUniversity of CaliforniaDavisUSA
  2. 2.M.I.N.D. InstituteUniversity of CaliforniaDavisUSA
  3. 3.Department of Public Health SciencesUniversity of CaliforniaDavisUSA
  4. 4.Department of Psychiatry and Behavioral SciencesUniversity of CaliforniaDavisUSA
  5. 5.Department of Biochemistry and Molecular MedicineUniversity of CaliforniaDavisUSA
  6. 6.Department of PediatricsUniversity of CaliforniaDavisUSA
  7. 7.Department of PsychologyUniversity of CaliforniaDavisUSA

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