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Brain region white matter associations with visual selective attention

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Abstract

To understand how normal variations in white matter relate to cognition, magnetization transfer imaging ratios (MTR) of a hypothesized neural network were associated with a test of visual selective attention (VST). Healthy adults (N = 16) without abnormal signal on brain scans viewed a version of DeSchepper and Treisman’s test of VST (1996) with two levels of processing (novel shape matching with and without distractors, contingency feedback). A hypothesized neural network and component regions was significantly associated with accuracy and response times when distractors were present, with betas predicting 55% of variance in accuracy, and 59% of response times. MTR for anterior and posterior cingulate, prefrontal region, and thalami comprised a model predicting 55% of accuracy when distractors were present, and the anterior cingulate accounted for the majority of this effect. Prefrontal MTR predicted longer response times which was associated with increased accuracy. Distal neural areas involved in complex, processing-driven tasks (error processing, response selection, and variable response competition and processing load) may be dependent on white matter fibers to connect distal brain regions/nuclei of a macronetwork, including prefrontal executive functions.

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Acknowledgements

This study was supported in part by a grant to the corresponding author from the National Cancer Institute RO1 CA65438, and by the research funds of Peter Phillips, M.D., Director of the Neuro-Oncology Program of Children’s Hospital of Philadelphia, and Hubert J.P. and Anne Faulkner Schoemaker Endowed Chair in Pediatric Neuro-Oncology.

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  1. Division of Oncology/Neuro-Oncology, Children’s Hospital of Philadelphia, 3535 Market Street, Philadelphia, PA, 19104, USA

    Christie Burger Seiler & Kelly E. Jones

  2. Department of Biostatistics, Children’s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, USA

    David Shera

  3. Division of Oncology/Neuro-Oncology and the Department of Neurology, Children’s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA, 19104, USA

    Carol L. Armstrong

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Correspondence to Carol L. Armstrong.

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Seiler, C.B., Jones, K.E., Shera, D. et al. Brain region white matter associations with visual selective attention. Brain Imaging and Behavior 5, 262–273 (2011). https://doi.org/10.1007/s11682-011-9130-7

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