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Effects of temporarily disrupting BBB on activity-induced manganese-dependent functional MRI

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Abstract

This study further investigates the influence of temporarily disrupting the blood-brain barrier (BBB) on the level of manganese used in AIM fMRI other than the recognized function of allowing that substance to enter into the activated brain regions more effectively during the BBB opening. We injected manganese into Wistar rats through ICA following the disruption of BBB with mannitol in a functional MRI test of the visual cortex. Through comparing MRI signal intensity and manganese contents in the visual cortex of rats received visual stimuli of unequal degree after the restoration of BBB, we found that the signal in the visual cortex could be further enhanced on T1WI given visual stimulation after the restoration of BBB. Temporary BBB disruption has an additional advantage in allowing Mn2+ to enter the CSF or brain for later transference to the activated brain area. So the dosage of manganese in AIM fMRI could be minimized by extending the stimulus.

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Acknowledgements

This research was supported by Funds for Key Sci-Tech Research Projects of Guangdong Province [YUECAIJIAO (2008) 258-2008A030201019, YUE KEJIBAN (2007) 05/06-7005206], and Funds for Key Sci-Tech Research Projects of Guangzhou [SUIKETIAOZI (2008)3-2008A1-E4011-6, 09B52120112-2009J1-C418-2] to Prof. Xiaodan Jiang.

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Authors and Affiliations

  1. Department of Neurosurgery, Neurosurgery Institute, Key Laboratory on Brain Function Repair and Regeneration of Guangdong, Zhujiang Hospital of Southern Medical University, 253# Gongye Road, Guangzhou, 510282, People’s Republic of China

    Zhiqiang Fa, Run Zhang, Peng Li, Peng Zhang, Qu Wu, Lujun Yang, Haigang Chang & Xiaodan Jiang

  2. Biomechanics & Medical Information Institute, Beijing University of Technology, Beijing, 100022, China

    Jing Zhang & Yanjun Zeng

  3. Department of Gynecology and obstetrics, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China

    Shaofang Zhu

  4. Department of Imageology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China

    Fanheng Huang & Zhibo Wen

  5. Department of Psychology, Center for Functional Brain Imaging, Sun Yat-Sen University, Guangzhou, 510275, China

    Yanping Liu & Dingguo Gao

Authors
  1. Zhiqiang Fa
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  2. Run Zhang
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  3. Peng Li
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  4. Jing Zhang
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  5. Peng Zhang
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  6. Shaofang Zhu
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  7. Qu Wu
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  8. Fanheng Huang
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  9. Yanping Liu
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  10. Lujun Yang
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  11. Haigang Chang
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  12. Zhibo Wen
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  13. Dingguo Gao
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  14. Yanjun Zeng
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  15. Xiaodan Jiang
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Corresponding authors

Correspondence to Dingguo Gao, Yanjun Zeng or Xiaodan Jiang.

Additional information

Zhiqiang Fa, Run Zhang and Peng Li, These authors contributed equally to this research

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Fa, Z., Zhang, R., Li, P. et al. Effects of temporarily disrupting BBB on activity-induced manganese-dependent functional MRI. Brain Imaging and Behavior 5, 181–188 (2011). https://doi.org/10.1007/s11682-011-9122-7

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  • DOI: https://doi.org/10.1007/s11682-011-9122-7

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