Abstract
An Inattentive/Overactive (I/O) behavioral phenotype has been reported in a significant percentage of children raised from birth in orphanages. While a number of studies have identified both functional and structural brain abnormalities in children raised from birth in orphanages, no published studies have evaluated potential neural correlates of the I/O phenotype. We applied diffusion tensor imaging (DTI) to 15 pre-teen children raised in orphanages in Eastern Europe or Asia and later adopted to the US. Fiber tracts were constructed from DTI data using probabilistic fiber tracking and the cortical fiber distribution of fibers originating from the head of the caudate was compared between the early deprivation (ED) group and 12 age-matched controls. The ED group showed a more diffuse connectivity pattern, especially in the right hemisphere, potentially related to incomplete neuronal pruning during development. These structural abnormalities may be associated with inattention and overactivity encountered in children with ED.
References
Behen, M. E., Helder, E., Rothermel, R., Solomon, K., & Chugani, H. T. (2008). Incidence of specific absolute neurocognitive impairment in globally intact children with histories of early severe deprivation. Child Neuropsychology, 14, 453–469.
Chatterjee, D., Chatterjee-Chakraborty, M., Rees, S., Cauchi, J., de Medeiros, C. B., & Fleming, A. S. (2007). Maternal isolation alters the expression of neural proteins during development: 'Stroking' stimulation reverses these effects. Brain Research, 1158, 11–27.
Chugani, H. T., Behen, M. E., Muzik, O., Juhasz, C., Nagy, F., & Chugani, D. C. (2001). Local brain functional activity following early deprivation: A study of postinstitutionalized Romanian orphans. Neuroimage, 14, 1290–1301.
Coe, C. L., Kramer, M., Czéh, B., Gould, E., Reeves, A. J., Kirschbaum, C., et al. (2003). Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys. Biological Psychiatry, 54, 1025–34.
Cordero, M. E., D'Acuna, E., Benveniste, S., Prado, R., Nunez, J. A., & Colombo, M. (1993). Dendritic development in neocortex of infants with early postnatal life undernutrition. Pediatric Neurology, 9, 457–464.
Eluvathingal, T. J., Chugani, H. T., Behen, M. E., Juhasz, C., Muzik, O., Maqbool, M., et al. (2006). Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study. Pediatrics, 117, 2093–2100.
Friman, O., Farnebäck, G., & Westin, C. F. (2006). A Bayesian approach for stochastic white matter tractography. IEEE Transactions on Medical Imaging, 25, 965–78.
Giedd, J. N., Blumenthal, J., Molloy, E., & Castellanos, F. X. (2001). Brain imaging of attention deficit/hyperactivity disorder. Annals of the New York Academy of Sciences, 931, 33–49.
Gordon, M., & Mettelman, B. (1988). The assessment of attention: I Standardization and reliability of behavior-based measure. Journal of Clinical Psychology, 44(5), 682–690.
Govindan, R. M., Makki, M. I., Sundaram, S. K., et al. (2008). Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy. Epilepsy Research, 80(1), 30–41.
Gunnar, M. R., Morison, S. J., Chisholm, K., & Schuder, M. (2001). Salivary cortisol levels in children adopted from romanian orphanages. Development and Psychopathology, 13, 611–628.
Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000). Effects of early adverse experiences on brain structure and function: Clinical implications. Biological Psychiatry, 48, 778–790.
Lozoff, B. (2007). Iron deficiency and child development. Food & Nutrition Bulletin, 28, S560–571.
Miller, L. C., Chan, W., Reece, R. A., Tirella, L. G., & Pertman, A. (2007). Child abuse fatalities among internationally adopted children. Child Maltreatment, 12, 378–80.
Mirescu, C., Peters, J. D., & Gould, E. (2004). Early life experience alters response of adult neurogenesis to stress. Nature Neuroscience, 7, 841–6.
Muzik, O., Chugani, D. C., Zou, G., Hua, J., Lu, Y., Lu, S., et al. (2007). Multimodality data integration in epilepsy. International Journal of Biomedical Imaging 13963.
Pavuluri, M. N., Yang, S., Kamineni, K., et al. (2009). Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit/hyperactivity disorder. Biological Psychiatry, 65, 586–593.
Reynolds, C. R., & Kamphaus, R. W. (1992). Behavior assessment scale for children. Circle Pines, MN: AGS.
Shaw, P., Eckstrand, K., Sharp, W., Blumenthal, J., Lerch, J. P., Greenstein, D., et al. (2007). Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences of the United States of America, 104(49), 19649–54.
Spadoni, A. D., McGee, C. L., Fryer, S. L., & Riley, E. P. (2007). Neuroimaging and fetal alcohol spectrum disorders. Neuroscience and Biobehavioral Reviews, 31, 239–245.
Stevens, S. E., Sonuga-Barke, E. J., Kreppner, J. M., Beckett, C., Castle, J., Colvert, E., et al. (2008). Inattention/overactivity following early severe institutional deprivation: presentation and associations in early adolescence. Journal of Abnormal Child Psychology, 36, 385–398.
Van den Bergh, B. R., Mulder, E. J., Mennes, M., & Glover, V. (2005). Antenatal maternal anxiety and stress and the neurobehavioural development of the fetus and child: links and possible mechanisms. A review. Neuroscience and Biobehavioral Reviews, 29, 237–258.
Wechsler, D. (1991). Wechsler intelligence scale for children (3rd ed.). San Antonio, TX: Psychological Corp.
Zou, G., Hua, J., Gu, X., & Muzik, O. (2006). An approach for 3D brain function analysis based on statistical conformal geometry. In: Proceedings of International Conference on Image Processing.
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The project described was partially supported by Grant number K08MH079176 from the National Institute of Mental Health to the first author. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Mental Health or the National Institutes of Health.
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Behen, M.E., Muzik, O., Saporta, A.S.D. et al. Abnormal Fronto-striatal Connectivity in Children with Histories of Early Deprivation: A Diffusion Tensor Imaging Study. Brain Imaging and Behavior 3, 292–297 (2009). https://doi.org/10.1007/s11682-009-9071-6
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DOI: https://doi.org/10.1007/s11682-009-9071-6