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Altered Finger Representations in Sensorimotor Cortex of Musicians with Focal Dystonia: Precentral Cortex

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Abstract

Using functional magnetic resonance imaging (fMRI), finger representations were characterized in the precentral cortex of 11 normal musicians and 14 musicians with focal task-specific dystonia. Finger representations were identified from differential activation during repetitive movements of each finger relative to others. Despite group similarities in topography, abnormalities in representations of affected fingers were identified. For the finger showing chronic flexion (primary dystonic finger or PDF), the cortical “disparity” from its normal location and the distance to the adjacent finger were increased. By contrast, representational characteristics of the finger showing chronic extension (primary compensatory finger or PCF) did not differ significantly from the control group, but did differ from those of the PDF. Regardless of whether either finger's representation differed substantively from normal, the PCF consistently showed greater volume of activation than the PDF or other fingers. These findings reflect dysfunctional interactions between at least two fingers and their cortical representations.

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References

  • Backes, W. H., & van Dijk, P. (2002). Simultaneous sampling of event-related BOLD responses in auditory cortex and brainstem. Magnetic Resonance in Medicine, 47(1), 90–96. doi:10.1002/mrm.10015.

    Article  PubMed  CAS  Google Scholar 

  • Beisteiner, R., Gartus, A., Erdler, M., Mayer, D., Lanzenberger, R., & Deecke, L. (2004). Magnetoencephalography indicates finger motor somatotopy. The European Journal of Neuroscience, 19(2), 465–472. doi:10.1111/j.1460-9568.2004.03115.x.

    Article  PubMed  Google Scholar 

  • Beisteiner, R., Windischberger, C., Lanzenberger, R., Edward, V., Cunnington, R., Erdler, M., et al. (2001). Finger somatotopy in human motor cortex. NeuroImage, 13(6 Pt 1), 1016–1026 see comment. doi:10.1006/nimg.2000.0737.

    Article  PubMed  CAS  Google Scholar 

  • Bitan, T., Burman, D. D., Lu, D., Cone, N. E., Gitelman, D. R., Mesulam, M. M., et al. (2006). Weaker top-down modulation from the left inferior frontal gyrus in children. NeuroImage, 33(3), 991–998. doi:10.1016/j.neuroimage.2006.07.007.

    Article  PubMed  Google Scholar 

  • Black, K. J., Ongur, D., & Perlmutter, J. S. (1998). Putamen volume in idiopathic focal dystonia. Neurology, 51(3), 819–824.

    PubMed  CAS  Google Scholar 

  • Boroojerdi, B., Foltys, H., Krings, T., Spetzger, U., Thron, A., & Topper, R. (1999). Localization of the motor hand area using transcranial magnetic stimulation and functional magnetic resonance imaging. Clinical Neurophysiology, 110(4), 699–704. doi:10.1016/S1388-2457(98)00027-3.

    Article  PubMed  CAS  Google Scholar 

  • Butterworth, S., Francis, S., Kelly, E., McGlone, F., Bowtell, R., & Sawle, G. V. (2003). Abnormal cortical sensory activation in dystonia: an fMRI study. Movement Disorders, 18(6), 673–682. doi:10.1002/mds.10416.

    Article  PubMed  Google Scholar 

  • Byl, N. N., McKenzie, A., & Nagarajan, S. S. (2000). Differences in somatosensory hand organization in a healthy flutist and a flutist with focal hand dystonia: a case report. Journal of Hand Therapy, 13(4), 302–309.

    PubMed  CAS  Google Scholar 

  • Byl, N. N., Nagajaran, S., & McKenzie, A. L. (2003). Effect of sensory discrimination training on structure and function in patients with focal hand dystonia: a case series. Archives of Physical Medicine and Rehabilitation, 84(10), 1505–1514. doi:10.1016/S0003-9993(03)00276-4.

    Article  PubMed  Google Scholar 

  • Candia, V., Schafer, T., Taub, E., Rau, H., Altenmuller, E., Rockstroh, B., et al. (2002). Sensory motor retuning: a behavioral treatment for focal hand dystonia of pianists and guitarists. Archives of Physical Medicine and Rehabilitation, 83(10), 1342–1348. doi:10.1053/apmr.2002.35094.

    Article  PubMed  Google Scholar 

  • Ceballos-Baumann, A. O., & Brooks, D. J. (1997). Basal ganglia function and dysfunction revealed by PET activation studies. Advances in Neurology, 74, 127–139.

    PubMed  CAS  Google Scholar 

  • Cohen, L. G., & Hallett, M. (1988). Hand cramps: clinical features and electromyographic patterns in a focal dystonia. Neurology, 38(7), 1005–1012.

    PubMed  CAS  Google Scholar 

  • Dechent, P., & Frahm, J. (2003). Functional somatotopy of finger representations in human primary motor cortex. Human Brain Mapping, 18(4), 272–283. doi:10.1002/hbm.10084.

    Article  PubMed  Google Scholar 

  • Delmaire, C., Krainik, A., Tezenas du Montcel, S., Gerardin, E., Meunier, S., Mangin, J. F., et al. (2005). Disorganized somatotopy in the putamen of patients with focal hand dystonia. Neurology, 64(8), 1391–1396.

    PubMed  CAS  Google Scholar 

  • Delmaire, C., Vidailhet, M., Elbaz, A., Bourdain, F., Bleton, J. P., Sangla, S., et al. (2007). Structural abnormalities in the cerebellum and sensorimotor circuit in writer's cramp. Neurology, 69(4), 376–380 see comment. doi:10.1212/01.wnl.0000266591.49624.1a.

    Article  PubMed  CAS  Google Scholar 

  • Deuschl, G., Toro, G., Matsumoto, J., & Hallett, M. (1995). Movement-related cortical potentials in writer's cramp. Annals of Neurology, 38, 862–868. doi:10.1002/ana.410380606.

    Article  PubMed  CAS  Google Scholar 

  • Dresel, C., Castrop, F., Haslinger, B., Wohlschlaeger, A. M., Hennenlotter, A., & Ceballos-Baumann, A. O. (2005). The functional neuroanatomy of coordinated orofacial movements: sparse sampling fMRI of whistling. NeuroImage, 28(3), 588–597. doi:10.1016/j.neuroimage.2005.06.021.

    Article  PubMed  Google Scholar 

  • Elbert, T., Candia, V., Altenmuller, E., Rau, H., Sterr, A., Rockstroh, B., et al. (1998). Alteration of digital representations in somatosensory cortex in focal hand dystonia. Neuroreport, 9(16), 3571–3575. doi:10.1097/00001756-199811160-00006.

    Article  PubMed  CAS  Google Scholar 

  • Fahn, S. (1988). Blepharospasm: a form of focal dystonia. Advances in Neurology, 49, 125–133.

    PubMed  CAS  Google Scholar 

  • Georgopoulos, A. P., Pellizzer, G., Poliakov, A. V., & Schieber, M. H. (1999). Neural coding of finger and wrist movements. Journal of Computational Neuroscience, 6(3), 279–288. doi:10.1023/A:1008810007672.

    Article  PubMed  CAS  Google Scholar 

  • Grafton, S. T., Woods, R. P., Mazziotta, J. C., & Phelps, M. E. (1991). Somatotopic mapping of the primary motor cortex in humans: activation studies with cerebral blood flow and positron emission tomography. Journal of Neurophysiology, 66(3), 735–743.

    PubMed  CAS  Google Scholar 

  • Hall, D. A., Haggard, M. P., Akeroyd, M. A., Palmer, A. R., Summerfield, A. Q., Elliott, M. R., et al. (1999). “Sparse” temporal sampling in auditory fMRI. Human Brain Mapping, 7(3), 213–223. doi:10.1002/(SICI)1097-0193(1999)7:3<213::AID-HBM5>3.0.CO;2-N.

    Article  PubMed  CAS  Google Scholar 

  • Hallett, M. (1993). Physiology of basal ganglia disorders: an overview. The Canadian Journal of Neurological Sciences, 20(3), 177–183.

    PubMed  CAS  Google Scholar 

  • Hallett, M. (1998). The neurophysiology of dystonia. Archives of Neurology, 55(5), 601–603. doi:10.1001/archneur.55.5.601.

    Article  PubMed  CAS  Google Scholar 

  • Hallett, M. (2004). Dystonia: abnormal movements result from loss of inhibition. Advances in Neurology, 94, 1–9.

    PubMed  Google Scholar 

  • Hlustik, P., Solodkin, A., Gullapalli, R. P., Noll, D. C., & Small, S. L. (2001). Somatotopy in human primary motor and somatosensory hand representations revisited. Cerebral Cortex (New York, N.Y.), 11(4), 312–321. doi:10.1093/cercor/11.4.312.

    Article  CAS  Google Scholar 

  • Hlustik, P., Solodkin, A., Noll, D. C., & Small, S. L. (2004). Cortical plasticity during three-week motor skill learning. Journal of Clinical Neurophysiology, 21(3), 180–191. doi:10.1097/00004691-200405000-00006.

    Article  PubMed  Google Scholar 

  • Ibanez, V., Sadato, N., Karp, B., Deiber, M. P., & Hallett, M. (1999). Deficient activation of the motor cortical network in patients with writer's cramp. Neurology, 53(1), 96–105.

    PubMed  CAS  Google Scholar 

  • Karbe, H., Holthoff, V. A., Rudolf, J., Herholz, K., & Heiss, W. D. (1992). Positron emission tomography demonstrates frontal cortex and basal ganglia hypometabolism in dystonia. Neurology, 42(8), 1540–1544.

    PubMed  CAS  Google Scholar 

  • Kleinschmidt, A., Nitschke, M. F., & Frahm, J. (1997). Somatotopy in the human motor cortex hand area. A high-resolution functional MRI study. The European Journal of Neuroscience, 9(10), 2178–2186. doi:10.1111/j.1460-9568.1997.tb01384.x.

    Article  PubMed  CAS  Google Scholar 

  • Krings, T., Topper, R., Foltys, H., Erberich, S., Sparing, R., Willmes, K., et al. (2000). Cortical activation patterns during complex motor tasks in piano players and control subjects. A functional magnetic resonance imaging study. Neuroscience Letters, 278, 189–193. doi:10.1016/S0304-3940(99)00930-1.

    Article  PubMed  CAS  Google Scholar 

  • Krumhansl, C. L. (2003). Experimental strategies for understanding the role of experience in music cognition. Annals of the New York Academy of Sciences, 999, 414–428. doi:10.1196/annals.1284.052.

    Article  PubMed  Google Scholar 

  • Leijnse, J. N. (1997). Anatomical factors predisposing to focal dystonia in the musician's hand-principles, theoretical examples, clinical significance. Journal of Biomechanics, 30(7), 659–669. doi:10.1016/S0021-9290(97)00008-0.

    Article  PubMed  CAS  Google Scholar 

  • Lerner, A., Shill, H., Hanakawa, T., Bushara, K., Goldfine, A., & Hallett, M. (2004). Regional cerebral blood flow correlates of the severity of writer's cramp symptoms. NeuroImage, 21(3), 904–913. doi:10.1016/j.neuroimage.2003.10.019.

    Article  PubMed  Google Scholar 

  • Lim, V. K., Altenmuller, E., & Bradshaw, J. L. (2001). Focal dystonia: current theories. Human Movement Science, 20(6), 875–914. doi:10.1016/S0167-9457(01)00076-8.

    Article  PubMed  CAS  Google Scholar 

  • Lotze, M., Erb, M., Flor, H., Huelsmann, E., Godde, B., & Grodd, W. (2000). fMRI evaluation of somatotopic representation in human primary motor cortex. NeuroImage, 11(5 Pt 1), 473–481. doi:10.1006/nimg.2000.0556.

    Article  PubMed  CAS  Google Scholar 

  • Marsden, C. D., Obeso, J. A., Zarranz, J. J., & Lang, A. E. (1985). The anatomical basis of symptomatic hemidystonia. Brain, 108(Pt 2), 463–483. doi:10.1093/brain/108.2.463.

    Article  PubMed  Google Scholar 

  • Meister, I., Krings, T., Foltys, H., Boroojerdi, B., Muller, M., Topper, R., et al. (2005). Effects of long-term practice and task complexity in musicians and nonmusicians performing simple and complex motor tasks: implications for cortical motor organization. Human Brain Mapping, 25(3), 345–352. doi:10.1002/hbm.20112.

    Article  PubMed  Google Scholar 

  • Munte, T. F., Altenmuller, E., & Jancke, L. (2002). The musician's brain as a model of neuroplasticity. Nature Reviews. Neuroscience, 3(6), 473–478.

    PubMed  Google Scholar 

  • Niyazov, D. M., Butler, A. J., Kadah, Y. M., Epstein, C. M., & Hu, X. P. (2005). Functional magnetic resonance imaging and transcranial magnetic stimulation: effects of motor imagery, movement and coil orientation. Clinical Neurophysiology, 116(7), 1601–1610. doi:10.1016/j.clinph.2005.02.028.

    Article  PubMed  CAS  Google Scholar 

  • Pantev, C., Engelien, A., Candia, V., & Elbert, T. (2001). Representational cortex in musicians. Plastic alterations in response to musical practice. Annals of the New York Academy of Sciences, 930, 300–314.

    PubMed  CAS  Google Scholar 

  • Pascual-Leone, A., Nguyet, D., Cohen, L. G., Brasil-Neto, J. P., Cammarota, A., & Hallett, M. (1995). Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. Journal of Neurophysiology, 74, 1037–1045.

    PubMed  CAS  Google Scholar 

  • Peller, M., Zeuner, K. E., Munchau, A., Quartarone, A., Weiss, M., Knutzen, A., et al. (2006). The basal ganglia are hyperactive during the discrimination of tactile stimuli in writer's cramp. Brain, 129(Pt 10), 2697–2708. doi:10.1093/brain/awl181.

    Article  PubMed  CAS  Google Scholar 

  • Penfield, W., & Rasmussen, T. (1950). Somatomotor responses. In W. Penfield, & T. Rasmussen (Eds.), The Cerebral Cortex of Man (pp. 46–57). New York: Macmillan.

    Google Scholar 

  • Pujol, J., Roset-Llobet, J., Rosines-Cubells, D., Deus, J., Narberhaus, B., Valls-Sole, J., et al. (2000). Brain cortical activation during guitar-induced hand dystonia studied by functional MRI. NeuroImage, 12(3), 257–267. doi:10.1006/nimg.2000.0615.

    Article  PubMed  CAS  Google Scholar 

  • Rao, S. M., Binder, J. R., Hammeke, T. A., Bandettini, P. A., Bobholz, J. A., Frost, J. A., et al. (1995). Somatotopic mapping of the human primary motor cortex with functional magnetic resonance imaging. Neurology, 45, 919–924.

    PubMed  CAS  Google Scholar 

  • Raos, V., Franchi, G., Gallese, V., & Fogassi, L. (2003). Somatotopic organization of the lateral part of area F2 (dorsal premotor cortex) of the macaque monkey. Journal of Neurophysiology, 89(3), 1503–1518. doi:10.1152/jn.00661.2002.

    Article  PubMed  Google Scholar 

  • Roberts, T. P., Zusman, E., McDermott, M., Barbaro, N., & Rowley, H. A. (1995). Correlation of functional magnetic source imaging with intraoperative cortical stimulation in neurosurgical patients. Journal of Image Guided Surgery, 1(6), 339–347. doi:10.1002/(SICI)1522-712X(1995)1:6<339::AID-IGS5>3.0.CO;2-B.

    Article  PubMed  CAS  Google Scholar 

  • Rotte, M., Kanowski, M., & Heinze, H. J. (2002). Functional magnetic resonance imaging for the evaluation of the motor system: primary and secondary brain areas in different motor tasks. Stereotactic and Functional Neurosurgery, 78(1), 3–16. doi:10.1159/000063834.

    Article  PubMed  Google Scholar 

  • Sanes, J. N., & Donoghue, J. P. (2000). Plasticity and primary motor cortex. Annual Review of Neuroscience, 23, 393–415. doi:10.1146/annurev.neuro.23.1.393.

    Article  PubMed  CAS  Google Scholar 

  • Sanes, J. N., Donoghue, J. P., Thangaraj, V., Edelman, R. R., & Warach, S. (1995). Shared neural substrates controlling hand movements in human motor cortex. Science, 268(5218), 1775–1777 see comment. doi:10.1126/science.7792606.

    Article  PubMed  CAS  Google Scholar 

  • Schieber, M. H. (1999). Somatotopic gradients in the distributed organization of the human primary motor cortex hand area: evidence from small infarcts. Experimental Brain Research, 128(1–2), 139–148. doi:10.1007/s002210050829.

    Article  CAS  Google Scholar 

  • Schieber, M. H. (2001). Constraints on somatotopic organization in the primary motor cortex. Journal of Neurophysiology, 86(5), 2125–2143.

    PubMed  CAS  Google Scholar 

  • Schieber, M. H., & Hibbard, L. S. (1993). How somatotopic is the motor cortex hand area? Science, 261(5120), 489–492. doi:10.1126/science.8332915.

    Article  PubMed  CAS  Google Scholar 

  • Schlaug, G., Sanes, J. N., Thangaraj, V., Darby, D. G., Jancke, L., Edelman, R. R., et al. (1996). Cerebral activation covaries with movement rate. Neuroreport, 7(4), 879–883. doi:10.1097/00001756-199603220-00009.

    Article  PubMed  CAS  Google Scholar 

  • Schwenkreis, P., El Tom, S., Ragert, P., Pleger, B., Tegenthoff, M., & Dinse, H. R. (2007). Assessment of sensorimotor cortical representation asymmetries and motor skills in violin players. The European Journal of Neuroscience, 26(11), 3291–3302. doi:10.1111/j.1460-9568.2007.05894.x.

    Article  PubMed  Google Scholar 

  • Shoham, D., & Grinvald, A. (2001). The cortical representation of the hand in macaque and human area S-I: high resolution optical imaging. The Journal of Neuroscience, 21(17), 6820–6835.

    PubMed  CAS  Google Scholar 

  • Slobounov, S., Chiang, H., Johnston, J., & Ray, W. (2002). Modulated cortical control of individual fingers in experienced musicians: an EEG study. Clinical Neurophysiology, 113(12), 2013–2024. doi:10.1016/S1388-2457(02)00298-5.

    Article  PubMed  CAS  Google Scholar 

  • Smith, J. F., Chen, K., Johnson, S., Morrone-Strupinsky, J., Reiman, E. M., Nelson, A., et al. (2006). Network analysis of single-subject fMRI during a finger opposition task. NeuroImage, 32, 325–332. doi:10.1016/j.neuroimage.2005.12.010.

    Article  PubMed  Google Scholar 

  • Stippich, C., Ochmann, H., & Sartor, K. (2002). Somatotopic mapping of the human primary sensorimotor cortex during motor imagery and motor execution by functional magnetic resonance imaging. Neuroscience Letters, 331(1), 50–54. doi:10.1016/S0304-3940(02)00826-1.

    Article  PubMed  CAS  Google Scholar 

  • Tempel, L. W., & Perlmutter, J. S. (1993). Abnormal cortical responses in patients with writer's cramp. Neurology, 43(11), 2252–2257 erratum appears in Neurology 1994 Dec;44(12):2411.

    PubMed  CAS  Google Scholar 

  • Terao, Y., Ugawa, Y., Sakai, K., Miyauchi, S., Fukuda, H., Sasaki, Y., et al. (1998). Localizing the site of magnetic brain stimulation by functional MRI. Experimental Brain Research, 121(2), 145–152. doi:10.1007/s002210050446.

    Article  CAS  Google Scholar 

  • van Westen, D., Fransson, P., Olsrud, J., Rosen, B., Lundborg, G., & Larsson, E. M. (2004). Finger somatotopy in area 3b: an fMRI-study. BMC Neuroscience, 5, 28. doi:10.1186/1471-2202-5-28.

    Article  PubMed  Google Scholar 

  • Volkmann, J., Schnitzler, A., Witte, O. W., & Freund, H. (1998). Handedness and asymmetry of hand representation in human motor cortex. Journal of Neurophysiology, 79(4), 2149–2154.

    PubMed  CAS  Google Scholar 

  • Woolsey, C. N., Erickson, T. C., & Gilson, W. E. (1979). Localization in somatic sensory and motor areas of human cerebral cortex as determined by direct recording of evoked potentials and electrical stimulation. Journal of Neurosurgery, 51(4), 476–506.

    Article  PubMed  CAS  Google Scholar 

  • Zhuang, P., Li, Y., & Hallett, M. (2004). Neuronal activity in the basal ganglia and thalamus in patients with dystonia. Clinical Neurophysiology, 115(11), 2542–2557. doi:10.1016/j.clinph.2004.06.006.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of Scientific Research and Education, Wilmette, IL, USA

    Douglas D. Burman

  2. Dept. of Radiology, Evanston Northwestern Healthcare, Evanston, IL, USA

    Douglas D. Burman & Joel R. Meyer

  3. Dept. of Communication Sciences and Disorders, Northwestern University, Evanston, IL, USA

    Douglas D. Burman

  4. Rehabilitation Institute of Chicago, Chicago, IL, USA

    Theresa Lie-Nemeth, Alice G. Brandfonbrener & Thomas Parisi

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Burman, D.D., Lie-Nemeth, T., Brandfonbrener, A.G. et al. Altered Finger Representations in Sensorimotor Cortex of Musicians with Focal Dystonia: Precentral Cortex. Brain Imaging and Behavior 3, 10–23 (2009). https://doi.org/10.1007/s11682-008-9046-z

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