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Ätiologie und Pathogenese der Arthrofibrose am Ellenbogen

Etiology and pathogenesis of arthrofibrosis of the elbow

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Zusammenfassung

Hintergrund

Die Arthrofibrose des Ellenbogens bringt Einschränkungen der Funktionalität des Arms mit sich. Diese Arbeit stellt eine Literaturübersicht zum aktuellen Stand der Wissenschaft dar.

Material und Methode

Übersichtsarbeit der aktuellen Literatur zum Thema Arthrofibrose am Ellenbogen und Analyse der beschriebenen ätiologischen Faktoren.

Ergebnisse

Die genaue Pathogenese der Arthrofibrose ist bisher ungeklärt. Es zeigen sich Hinweise auf auslösende Mechanismen auf zellulärer Ebene. Zytokine haben einen Einfluss auf lokale Inflammationsprozesse, die eine Veränderung der extrazellulären Matrix (EZM) von Myofibroblasten zur Folge haben. Das Verständnis der genauen Mechanismen ist bisher unvollständig.

Schlussfolgerung

Einzelne Mechanismen geben Grund zur Hoffnung, dass die Arthrofibrose am Ellenbogen in Zukunft besser verstanden und medikamentös behandelt werden könnte. Weitere Grundlagenforschung in diesem Gebiet ist notwendig.

Abstract

Background

Arthrofibrosis of the elbow is a common complication of elbow injuries and involves limitations in upper limb functionality. This is a review paper on the current state of research about elbow arthrofibrosis.

Methods

Review of the current literature on the subject; analysis of etiological factors.

Results

The exact pathogenesis of arthrofibrosis is still unclear. There are indications of triggering mechanisms at the cellular level. Cytokines affect local inflammatory responses, leading to a change in the extracellular matrix of myofibroblasts. However, the mechanisms are not yet fully understood.

Conclusion

Individual mechanisms give reason to hope that arthrofibrosis of the elbow could be better understood and treated with drugs in the future. Further basic research in this area is necessary.

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Authors and Affiliations

  1. Klinik und Poliklinik für Orthopädie, Unfallchirurgie und Plastisch-Ästhetische Chirurgie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland

    F. Krane B.Sc., M. Hackl, L. P. Müller & T. Leschinger

Authors
  1. F. Krane B.Sc.
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  2. M. Hackl
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  3. L. P. Müller
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  4. T. Leschinger
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Correspondence to F. Krane B.Sc..

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Interessenkonflikt

F. Krane, M. Hackl, L. P. Müller und T. Leschinger geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Krane, F., Hackl, M., Müller, L.P. et al. Ätiologie und Pathogenese der Arthrofibrose am Ellenbogen. Obere Extremität 18, 137–141 (2023). https://doi.org/10.1007/s11678-023-00751-x

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  • DOI: https://doi.org/10.1007/s11678-023-00751-x

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