Abstract
Objective: To investigate the clinicopathology and DNA ploidy of gastric mucosa associated lymphoid tissue (MALT) lymphoma infiltraving the leiomyomas of the uterus of a patient. Methods: The routine paraffin slides were cut, stained with HE, immunochemically by ABC methodusing the and stained by Feulgen method. Then the DNA ploidy of tumor cells was measured with an image cytometer. Results: In the mucosa, submucosa and the smooth muscle layer of the stomach and in the leiomyomas of the uterus there was diffusive and dense infiltration of centrocyte-like cells. The DNA measurement results were that the distribution of DNA mass of lymphoma cells in stomach and in lymph nodes had a single main aneuploidy peak each, and the distribution of DNA mass of lymphoma cells in leiomyomas of uterus had two peaks; one of them was the diploid, the other aneuploid. Conclusion: The MALT lymphoma cell invasion in uterus must be differentiated with a primary lymphoma in the uterus, the chronic lymphocyte leukemia in uterus and an endometrial stromal sarcoma. The present prognosis of the patient under discussion was poor. The follow-up results indicated the DNA index seemed to be important for predicting the malignancy degree and prognosis.
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References
Isaacson PG, Wright DH. Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 1984; 53: 2515.
Jaffe ES, Harris NL, Chan JKC, et al. Proposed World Health Organization classification of neoplastic diseases of hematopoietic and lymphoid tissues. Am J Surg pathol 1997; 21: 114.
Zhang Yajie, Gao Xulan, Li Yulin. The immunochemistry probe of five cases of MALT lymphoma. Chin J Pathol 1995; 6: 175.
Zhang Yajie, Li Yulin, Zhu Guibin, et al. Pathological study of gastrointestinal mucosa-associated lymphoid tissue-derived lymphoma. J Clin Exp Pathol 1994; 10: 119.
Zuo Lianfu, Gao Guodong, Guo Jianwen, et al. The analysis of malignant lymphoma with flow cytometer. Chin J Pathol 1989; 18: 151.
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This work was supported by a grant from the State Committee of Education of China (No. 436, 1997)
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Xiang, L., Xiangzhou, L., Yihua, W. et al. The clinical pathology and DNA ploidy of gastric mucosa associated lymphoid tissue (malt) lymphoma infiltrating the leiomyomas of the uterus. Chin. J. Cancer Res. 11, 282–284 (1999). https://doi.org/10.1007/s11670-999-0035-6
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DOI: https://doi.org/10.1007/s11670-999-0035-6