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Diagnosis of tumor-like polypoid lesions of gallbladder by serum proteomic fingerprint

  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

To search the specific serum proteins in tumor-like polypoid lesions of the gallbladder(PLG) patients.

Methods

Surface enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF-MS) technique and WCX Magnetic Beads were used to detect the serum proteomic fingerprint of 23 patients with tumor-like PLG, 21 patients with non tumor-like PLG and 26 normal persons. Biomarker Wizard and Biomarker Patterns Software were used in combination to analyze the data.

Results

In the preliminary screening, 22 representative specific proteins for tumor-like PLG were found. Seven specific proteins showed increased expression and 15 specific proteins showed decreased expression in the tumor-like PLG patients. Three specific proteins are selected for the diagnosis of the tumor-like PLG.

Conclusion

SELDI-TOF-MS technique can be used to select specific proteins for tumor-like PLG patients, which may be useful for the diagnosis of the tumor-like PLG and the differential diagnosis with the non tumor-like PLG.

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Authors and Affiliations

  1. Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Chun-lin Ge  (葛春林), Feng-ming Luan  (栾凤鸣) & Ning Ma  (马宁)

  2. Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, 100730, China

    Yong-zhe Li  (李永哲), Chao-jun Hu  (胡朝军) & Ning Li  (李宁)

Authors
  1. Chun-lin Ge  (葛春林)
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  2. Feng-ming Luan  (栾凤鸣)
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  3. Ning Ma  (马宁)
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  4. Yong-zhe Li  (李永哲)
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  5. Chao-jun Hu  (胡朝军)
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  6. Ning Li  (李宁)
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Corresponding author

Correspondence to Chun-lin Ge  (葛春林).

Additional information

This work was supported by the Scientific Research Foundation of the High School from Education Department of Liaoning Province (No. 20060923).

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Ge, Cl., Luan, Fm., Ma, N. et al. Diagnosis of tumor-like polypoid lesions of gallbladder by serum proteomic fingerprint. Chin. J. Cancer Res. 20, 286–289 (2008). https://doi.org/10.1007/s11670-008-0286-7

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  • DOI: https://doi.org/10.1007/s11670-008-0286-7

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