Skip to main content
SpringerLink
Log in

Pathological features of gastric cancer in Zhuanghe high-risk area in China during 1992–2005

  • Gastrointestinal Cancer
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

To investigate the pathological features and chronological changes of 1003 cases with gastric cancer in Zhuanghe high-risk area during 1992–2005 and the relationship between the changes and etiology factors in order to make a clue for gastric cancer prevention.

Methods

A total of 1003 gastric cancer specimens resected surgically between 1992–2005 in Zhuanghe Center Hospital were studied. The specimens were fixed in formalin and diagnosed by routine pathology.

Results

The incidence of patients with gastric cancer was highest at age of 60–69, the next high was at age of 50–59 and it was significantly higher in male than in female (P<0.001), the ratio was 3.0:1. During the past 14 years, there were 159 (15.9%) EGC, 195 (19.4%) moderate and 649 (64.7%) advanced gastric cancer detected. In macroscopical features, type III remained dominant in EGC, the next was mixed type in EGC. In advanced gastric cancer the Borrmann’s type III remained the dominant, the next was type II. For nodal metastasis, positive cases were decreasing and negative were increasing in EGC, moreover negative cases were higher than positive ones each year. There was no obvious trend in advanced cancer but positive cases were higher than negative ones each year. In histological features, papillary, moderately and poorly differentiated tubular adenocarcinoma remained downtrend, mucus adenocarcinoma and undifferentiation cancer remained uptrend year after year. The radio of intestinal to diffuse type decreased from 0.78 to 0.62 during the past 14 years.

Conclusion

There were significant chorological trends of pathological characteristic of gastric cancer in Zhuanghe high-risk area during the past 14 years.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Wang JY, Hsieh JS, Huang CJ, et al. Clinico-pathologic study of advanced gastric cancer without serosal invasion in young and old patients[J]. J Surg Oncol 1996; 63: 36–40.

    Article  PubMed  CAS  Google Scholar 

  2. Roder DM. The epidemiology of gastric cancer[J]. Gastric Cancer 2002; 5: 5–11.

    Article  PubMed  Google Scholar 

  3. Sunny L, Yeole BB, Hakama M. Decreasing trend in the incidence of stomach cancer in Mumbai, India, during 1988 to 1999[J]. Asian Pac J Cancer Prev 2004; 5: 169–174.

    PubMed  Google Scholar 

  4. Alberts SR, Cervantes A, van de Velde CJ. Gastric cancer: epidemiology, pathology and treatment[J]. Ann Oncol 2003; 14(Suppl.2): 1131–1136.

    Google Scholar 

  5. Yuan Y. Comprehensive prevention and treatment for high risk population in high risk area with gastric cancer in Zhuanghe region, Liaoning Province[J]. Zhongguo Zhongliu(in Chin) 2005; 14: 307–311.

    Google Scholar 

  6. Roviello F, Rossi S, Marrelli D, et al. Number of lymph node metastases and its prognostic significance in early gastric cancer: a multicenter Italian study[J]. J Surg Oncol 2006; 94: 275–280.

    Article  PubMed  Google Scholar 

  7. Marmo R, Rotondano G, Piscopo R, et al. Combination of age and sex improves the ability to predict upper gastrointestinal malignancy in patients with uncomplicated dyspepsia: a prospective multicentre database study[J]. Am J Gastroenterol 2005; 100: 784–791.

    Article  PubMed  Google Scholar 

  8. Türkdogan MK, Akman N, Tuncer I, et al. Epidemiological aspects of endemic upper gastro-intestinal cancers in eastern Turkey[J]. Hepatogastro-enterology 2005; 52: 496–500.

    Google Scholar 

  9. Faycal J, Bessaguet C, Nousbaum JB, et al. Epidemiology and long term survival of gastric carcinoma in the French district of Finistere between 1984 and 1995[J]. Gastroenterol Clin Biol 2005; 29: 23–32.

    Article  PubMed  Google Scholar 

  10. Bani-Hani KE, Yaghan RJ, Heis HA, et al. Gastric malignancies in Northern Jordan with special emphasis on descriptive epidemiology[J]. World J Gastroenterol 2004; 10: 2174–2178.

    PubMed  Google Scholar 

  11. Dobru D, Pascu O, Tantau M, et al. An epidemiological study of gastric cancer in the adult population referred to gastroenterology medical services in Romania a multicentric study[J]. Rom J Gastroenterol 2004; 13: 275–279.

    PubMed  Google Scholar 

  12. Sasazuki S, Inoue M, Hanaoka T, et al. Green tea consumption and subsequent risk of gastric cancer by subsite: the JPHC Study[J]. Cancer Causes Control 2004; 15: 483–491.

    Article  PubMed  Google Scholar 

  13. Tanaka K, Kiyohara Y, Kato I, et al. Incidence and prognosis of gastric cancer in a population-based cohort survey: the Hisayama study[J]. Scand J Gastroenterol 2004; 39: 459–463.

    Article  PubMed  CAS  Google Scholar 

  14. Khan MM, Goto R, Kobayashi K, et al. Dietary habits and cancer mortality among middle aged and older Japanese living in hokkaido, Japan by cancer site and sex[J]. Asian Pac J Cancer Prev 2004; 5: 58–65.

    PubMed  CAS  Google Scholar 

  15. Ershler WB, Longo DL. The biology of aging[J]. Cancer 1997; 80: 1284–1293.

    Article  PubMed  CAS  Google Scholar 

  16. Xing CZ, Yuan Y, Wang FC, et al. Characteristics of Gastric Cancer in screening[J]. Chin J Dig Endosc(in Chin) 2000; 17: 150–152.

    Google Scholar 

  17. Yuan Y, Gong W, Xu RT, et al. Gastric Cancer Screening in 30 villages of Zhuanghe Region-A Mass Screening Report from High Risk Area of Gastric Cancer in China[D]. The Proceeding of 4th International Gastric Cancer Congress, New York, USA, 2001; P637–P642.

  18. Lauren, P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma[J]. Acta Pathol Microbiol Scand 1965; 64: 31–49.

    PubMed  CAS  Google Scholar 

  19. Lauren PA, Nevalainen TJ. Epidemiology of intestinal and diffuse types of gastric carcinoma: a time-trend study in Finland with comparison between studies from high-and low-risk areas[J]. Cancer 1993; 71: 2926–2933.

    Article  PubMed  CAS  Google Scholar 

  20. Lin HZ, Zhang YC, Yuan Y, et al. Characteristics and Chronological Changes of Gastric Cancer in Liaoning Province[J]. J Chin Med Univ (in Chin)1990; 19: 185–188.

    Google Scholar 

  21. Chikusaku Nagayo. Decreasing trend of stomach cancer in Japan[J]. Jpn J Cancer Res (CANN) 1987; 78:1

    Google Scholar 

  22. Sipponen P, Järvi O. Decreased incidence of intestinal and diffuse type of gastric carcinoma in Finland during 20 year period[J]. Scand J Gastroenterol 1987; 22: 865.

    Article  PubMed  CAS  Google Scholar 

  23. Bahmanyar S, Ye W. Dietary patterns and risk of squamous-cell carcinoma and adenocarcinoma of the esophagus and adenocarcinoma of the gastric cardia: a population-based case-control study in Sweden[J]. Nutr Cancer 2006; 54: 171–178.

    Article  PubMed  Google Scholar 

  24. Kurosawa M, Kikuchi S, Xu J, et al. Highly salted food and mountain herbs elevate the risk for stomach cancer death in a rural area of Japan[J]. J Gastroenterol Hepatol 2006; 21: 1681–1686.

    Article  PubMed  Google Scholar 

  25. Sipponen P, Kekki M, Siurala M. Atrophic chronic gastritis and intestinal metaplasia in gastric carcinoma[J]. Cancer 1983; 52: 1062–1068.

    Article  PubMed  CAS  Google Scholar 

  26. Sun LP, Gong YH, Yuan Y. Serum pepsinogen concerntration as an index for Helicobacter pylori eradication[J]. World Chin J Digestol(in Chin) 2004; 12: 1827–1830.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Institute, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Yue-hua Gong  (宫月华), Li-ping Sun  (孙丽萍) & Yuan Yuan  (袁媛)

  2. Zhuanghe Center Hospital, Shenyang, Liaoning Province, 116400, China

    Yan-hou Liu  (刘彦厚), he Huang  (黄河), Guo-peng Sun  (孙国鹏), Quan-gang Wang  (王全刚) & Yuan-jun Yin  (尹远君)

Authors
  1. Yue-hua Gong  (宫月华)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li-ping Sun  (孙丽萍)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yan-hou Liu  (刘彦厚)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. he Huang  (黄河)
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Guo-peng Sun  (孙国鹏)
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Quan-gang Wang  (王全刚)
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yuan-jun Yin  (尹远君)
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yuan Yuan  (袁媛)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yuan Yuan  (袁媛).

Additional information

This work was supported by the National “Tenth-Five” Key Technologies R&D Program of China (2004BA703B04-02)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gong, Yh., Sun, Lp., Liu, Yh. et al. Pathological features of gastric cancer in Zhuanghe high-risk area in China during 1992–2005. Chin. J. Cancer Res. 20, 262–267 (2008). https://doi.org/10.1007/s11670-008-0262-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11670-008-0262-2

Key words

CLC number

Search

Navigation