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Relationship of serum interleukin-18 and interleukin-12 levels with clinicopathology in renal cell carcinoma

  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

To investigate the relationship between serum interleukin-18 and interleukin-12 levels and clinicopathology of renal cell carcinoma.

Methods

Peripheral blood samples were obtained from 20 healthy volunteers and 60 patients with renal cell carcinoma before curative surgery. IL-12 and IL-18 levels were determined by enzyme-linked immunosorbent assay.

Results

Mean serum IL-12 and IL-18 levels were significantly higher in patients with renal cell carcinoma compared with healthy volunteers (P<0.05) and mean serum IL-12 and IL-18 levels increased in patients as the pathologic stage progressed. A positive correlation was observed between serum IL-12 and IL-18 levels (P<0.05). In patients with renal cell carcinoma, increasing serum IL-12 and IL-18 levels correlated with pathological stage and Fuhrman grade.

Conclusion

Serum IL-12 and IL-18 might be useful tumor markers in patients with renal cell carcinoma.

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Authors and Affiliations

  1. Department of Urology, The First Affiliated Hospital, Soochow University, Suzhou, 215006, China

    Nong Shao-jun  (农绍军), Wen Duan-gai  (温端改), Fan Cai-bin  (樊彩斌) & Ouyang Jun  (欧阳骏)

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  1. Nong Shao-jun  (农绍军)
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  2. Wen Duan-gai  (温端改)
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  3. Fan Cai-bin  (樊彩斌)
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  4. Ouyang Jun  (欧阳骏)
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Correspondence to Wen Duan-gai  (温端改).

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Nong, Sj., Wen, Dg., Fan, Cb. et al. Relationship of serum interleukin-18 and interleukin-12 levels with clinicopathology in renal cell carcinoma. Chin. J. Cancer Res. 19, 304–308 (2007). https://doi.org/10.1007/s11670-007-0304-1

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  • DOI: https://doi.org/10.1007/s11670-007-0304-1

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