Abstract
Objective
To investigate the expressions of beta-catenin, SUFU and VEGFR-2 proteins in medulloblastoma.
Methods
Immunohistochemical staining with SP method was conducted to determine the expressions of beta-catenin, SUFU and VEGFR-2 in 33 cases of medulloblastoma and 10 normal cerebellar tissues.
Results
The abnormal expression rates of beta-catenin and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue. While the positive expression of SUFU gene in medulloblastoma was significantly lower than that in 10 normal cerebellar tissues. A significant negative correlation was found between beta-catenin and SUFU proteins and a positive correlation between beta-catenin and VEGFR-2 was found in medulloblastoma.
Conclusion
Beta-catenin, VEGFR-2 and SUFU have important effects on the pathogenesis and development of medulloblastoma.
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References
Frank T. Kolligs, Guido Bommer, Burkhard Göke. Wnt/Beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis[J]. Digestion 2002; 66: 131–144.
Takemaru KI, Yamaguchi S, Lee YS, et al. A nuclear β-catenin-associated antagonist of the Wnt/wingless pathway[J]. Nature 2003; 422: 905–909.
Masood R, Cai J, Zheng T, et al. Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors[J]. Blood 2001; 98: 1904–1913.
Michael DT, Liu L, Corey R, et al. Mutations in SUFU predispose to medulloblastoma[J]. Nature Genetics 2002; 31: 306–310.
David WE, Olabisi EO, Janet CL, et al. Beta-catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children’s Cancer Study Group Brain tumor Committee[J]. J Clin Oncol 2005; 23: 7951–7957.
Eberhart CG, Tihan T, Burger PC. Nuclear localization and mutation of β-catenin in medulloblastomas[J]. Neuropathol Exp Neurol 2000; 59: 333–337.
Kuhnert F, Davis CR, Wang HT, et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1[J]. Proc Natl Acad Sci USA 2004; 101: 66–71.
Katrin L, Marc AB, Carmen E, et al. Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin[J]. Clin Cancer Res 2005; 11: 4934–4940.
Skurk C, Maatz H, Rocnik E, et al. Glycogen-Synthase Kinase-3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells[J]. Circ Res 2005; 96: 308–318.
Goodlad RA, Ryan AJ, Wedge SR, et al. Inhibiting vascular endothelial growth factor signaling reduces tumor burden in the Apc Min/+ mouse model of early intestinal cancer[J]. Carcinogenesis 2006; 27: 2133–2139.
Ayanna FC, Kuan PY, Martina B, et al. Cardiac and CNS defects in a mouse with targeted disruption of suppressor of sused[J]. Development 2005; 132: 4407–4417.
Taylor MD, Zhang X, Liu L, et al. Failure of a medulloblastdsoma-derived mutant of SUFU to suppress WNT signaling[J]. Oncogene 2004; 23: 4577–4583.
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Zhang, X., Zhang, Hm., Li, Y. et al. Expressions of beta-catenin, SUFU and VEGFR-2 proteins in medulloblastoma. Chin. J. Cancer Res. 19, 299–303 (2007). https://doi.org/10.1007/s11670-007-0299-7
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DOI: https://doi.org/10.1007/s11670-007-0299-7