Skip to main content
SpringerLink
Log in

Inhibitory effect of Cantharidin on proliferation of A549 cells

  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

To study the inhibition of Cantharidin against the proliferation of human lung cancer A549 cells and its mechanism.

Methods

MTT assay was employed to determine the inhibition of Cantharidin against proliferation of A549 cells and flow Cytometry was applied to analyze A549 cell cycle and the effect of Cantharidin on cell cycle.

Results

Cantharidin showed inhibition against the proliferation of A549 cells, and the inhibition was mediated by blocking A549 cell cycle at G2/M phase significantly.

Conclusion

Cantharidin exhibits inhibition against the proliferation of human lung cancer A549 cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Jiang LH, Wang MY. Research progress on Mylabris[J]. Herald Med 2004; 23: 385–386.

    CAS  Google Scholar 

  2. Jin W, Wang YW, Zhou ZX, et al. The effects of canthacidiu on HL-60 and QGY7703 cell line[J]. Acta Chin Med Pharmacal 2001; 29: 42–43.

    Google Scholar 

  3. Li B, Ling CQ. Advances in basic and clinical studies of norcantharidin[J]. Chin Tradit Herbs Drugs(in Chin) 2002; 33: 184–185.

    Google Scholar 

  4. Li FZ, Ambrosini G, Chu EY, et al. Control of apoptosis and mitotic spindle checkpoint by Survivin[J]. Nature 1998; 396: 580–584.

    Article  PubMed  CAS  Google Scholar 

  5. Sun ZX, Wei YL, Zhao TD, et al. the studies of CTD and Norcantharidin induced HEL; human erythroleukemia K562 apoptosis[J]. J Anat(in Chin) 2000; 31: 56–60.

    CAS  Google Scholar 

  6. Sherr CJ. The pezcoler lecture: Cancer cell-cycles revisited[J]. Cancer Res 2000; 60: 3689–3695.

    PubMed  CAS  Google Scholar 

  7. Roberts JR, Allison DC, Donehower RC, et al. development of polyploidization in taxol resistant human leukemia cells in vitro[J]. Cancer Res 1990; 50: 710–716.

    PubMed  CAS  Google Scholar 

  8. Kerr JF, winterford CM, Harmon BV. Apoptosis, its significance in cancer and cancer therapy[J]. Cancer 1994; 73: 3108.

    Article  Google Scholar 

  9. Blagosklonny MV, Pardee AB. Exploiting cancer cell cycling for selective protection of normal cell[J]. Cancer Res 2001; 61: 4301–4305.

    PubMed  CAS  Google Scholar 

  10. Hartwell L, Kastsan MB. Cell cycle control and cancer[J]. Science 1994; 266: 1820–1828.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cancer Research Institute, First Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Wang Xiao-hua  (王晓华), Yin Yuan-qin  (尹元琴), Sui Cheng-guang  (隋承光), Meng Fan-dong  (孟凡东), Ma Ping  (马萍) & Jiang You-hong  (姜又红)

Authors
  1. Wang Xiao-hua  (王晓华)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yin Yuan-qin  (尹元琴)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sui Cheng-guang  (隋承光)
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Meng Fan-dong  (孟凡东)
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ma Ping  (马萍)
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jiang You-hong  (姜又红)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiang You-hong  (姜又红).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, Xh., Yin, Yq., Sui, Cg. et al. Inhibitory effect of Cantharidin on proliferation of A549 cells. Chin. J. Cancer Res. 19, 283–286 (2007). https://doi.org/10.1007/s11670-007-0283-2

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11670-007-0283-2

CLC number

Key words

Search

Navigation