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Expression of beta-catenin and APC protein in ovarian epithelial tumor and its implication

  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

To investigate the expression of beta-catenin, APC protein and its implication in ovarian epithelial tumor.

Methods

Immunohistochemical staining with SP method was conducted to determine the expression of beta-catenin and APC protein in 48 cases of ovarian epithelial tumor.

Results

The abnormal expression rates of beta-catenin in ovarian malignant and borderline epithelial tumors were higher than that in benign epithelial tumors. The expression of APC protein in benign epithelial tumors was significantly greater than that in malignant epithelial tumors. A significant negative correlation was found between beta-catenin and APC protein in ovarian epithelial tumors.

Conclusion

Beta-catenin and APC protein have important effect on pathogenesis and development of ovarian epithelial tumors.

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References

  1. Zhang MJ, Wang Q, Wang YH. Immunohistochemical detection and clinical significance of beta-catenin expression in human colorectal cancer [J]. Acad J Sec Mil Med Univ (Chin) 2000; 21:239–41.

    Google Scholar 

  2. Shimizu M, Saitoh Y, Itoh H. Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues [J]. Hum Pathol 1990; 21:607–12.

    Article  PubMed  CAS  Google Scholar 

  3. Gamallo C, Palacios J, Moreno G, et al. Beta-catenin expression pattern in stage I and II ovarian carcinomas: relationship with beta-catenin gene mutations, clinico-pathological features, and clinical outcome [J]. Am J Pathol 1999; 155:527–36.

    PubMed  CAS  Google Scholar 

  4. Moreno-Bueno G, Gamallo C, Perez-Grallego L, et al. Beta-catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas [J]. Diagn Mol Pathol 2001; 10:116–22.

    Article  PubMed  CAS  Google Scholar 

  5. Wu R, Zhai Y, Fearon ER, et al. Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas [J]. Cancer Res 2001; 61:8247–55.

    PubMed  CAS  Google Scholar 

  6. Karbova E, Davidson B, Metodiev K, et al. Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma [J]. Int J Surg Pathol 2002; 10:175–80.

    PubMed  CAS  Google Scholar 

  7. Jarrett CR, Blancato J, Cao T, et al. Human APC2 localization and allelic imbalance [J]. Cancer Res 2001; 61:7978–84.

    PubMed  CAS  Google Scholar 

  8. Thliveris A, Samowitz W, Matsunami N, et al. Demonstration of promoter activity and alternative splicing in the region 5′ to exon 1 of the APC gene [J]. Cancer Res 1994; 54:2991–5.

    PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

Authors

Corresponding author

Correspondence to Li Yu  (李昱).

Additional information

This project was supported by the Scientific and Technology Committee of Chongqing (No. 040307) and Research Start Fund of Chongqing Medical University (QD 200201).

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Lin, X., Li, Y. & Mi, C. Expression of beta-catenin and APC protein in ovarian epithelial tumor and its implication. Chin. J. Cancer Res. 19, 72–75 (2007). https://doi.org/10.1007/s11670-007-0072-y

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  • DOI: https://doi.org/10.1007/s11670-007-0072-y

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