Skip to main content
Log in

Expression of beta-catenin and APC protein in ovarian epithelial tumor and its implication

  • Published:
Chinese Journal of Cancer Research



To investigate the expression of beta-catenin, APC protein and its implication in ovarian epithelial tumor.


Immunohistochemical staining with SP method was conducted to determine the expression of beta-catenin and APC protein in 48 cases of ovarian epithelial tumor.


The abnormal expression rates of beta-catenin in ovarian malignant and borderline epithelial tumors were higher than that in benign epithelial tumors. The expression of APC protein in benign epithelial tumors was significantly greater than that in malignant epithelial tumors. A significant negative correlation was found between beta-catenin and APC protein in ovarian epithelial tumors.


Beta-catenin and APC protein have important effect on pathogenesis and development of ovarian epithelial tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Zhang MJ, Wang Q, Wang YH. Immunohistochemical detection and clinical significance of beta-catenin expression in human colorectal cancer [J]. Acad J Sec Mil Med Univ (Chin) 2000; 21:239–41.

    Google Scholar 

  2. Shimizu M, Saitoh Y, Itoh H. Immunohistochemical staining of Ha-ras oncogene product in normal, benign, and malignant human pancreatic tissues [J]. Hum Pathol 1990; 21:607–12.

    Article  PubMed  CAS  Google Scholar 

  3. Gamallo C, Palacios J, Moreno G, et al. Beta-catenin expression pattern in stage I and II ovarian carcinomas: relationship with beta-catenin gene mutations, clinico-pathological features, and clinical outcome [J]. Am J Pathol 1999; 155:527–36.

    PubMed  CAS  Google Scholar 

  4. Moreno-Bueno G, Gamallo C, Perez-Grallego L, et al. Beta-catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas [J]. Diagn Mol Pathol 2001; 10:116–22.

    Article  PubMed  CAS  Google Scholar 

  5. Wu R, Zhai Y, Fearon ER, et al. Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas [J]. Cancer Res 2001; 61:8247–55.

    PubMed  CAS  Google Scholar 

  6. Karbova E, Davidson B, Metodiev K, et al. Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma [J]. Int J Surg Pathol 2002; 10:175–80.

    PubMed  CAS  Google Scholar 

  7. Jarrett CR, Blancato J, Cao T, et al. Human APC2 localization and allelic imbalance [J]. Cancer Res 2001; 61:7978–84.

    PubMed  CAS  Google Scholar 

  8. Thliveris A, Samowitz W, Matsunami N, et al. Demonstration of promoter activity and alternative splicing in the region 5′ to exon 1 of the APC gene [J]. Cancer Res 1994; 54:2991–5.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Li Yu  (李昱).

Additional information

This project was supported by the Scientific and Technology Committee of Chongqing (No. 040307) and Research Start Fund of Chongqing Medical University (QD 200201).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lin, X., Li, Y. & Mi, C. Expression of beta-catenin and APC protein in ovarian epithelial tumor and its implication. Chin. J. Cancer Res. 19, 72–75 (2007).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

CLC number

Key words