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Correlation between laminin and cathespin D expressions in breast carcinoma

  • Published:
Chinese Journal of Cancer Research

Abstract

Objective

Laminin is a major glycoprotein component of basement membrance which is an important barrier to tumor cells which must be breeched before metastatic spread can occur. Proteolytic enzymes play an important role in mediating the passage of cancer cells through the basement membrane (BM) and extracellular matrix. We compared the patterns of laminin and cathepsin D (CD) expressions in a range of benign and malignant breast lesions to better understand the process of tumor progression.

Methods

One hundred and sixty-two cases of breast samples comprising 18 fibroadeomas, 22 cases of fibrocystic disease, 96 cases of invasive ductal carcinoma and 26 carcinomas with intraductal components were evaluated for laminin and cathepsin D expressions by immunohistochemical staining.

Results

The prevalence of CD positivity in both neoplastic and stromal cell components were significantly higher in higher histological grade tumors compared to lower grades (P<0.001). Various severity of BM disruption correlated with histological grade of the carcinomas (P<0.001). There was a negative correlation between the laminin expression and CD presence.

Conclusion

In the process of cancer cell invasion and metastasis, the basement membrane is disrupted by proteinase secreted by cancer cells, especially by stroma cells of cancer.

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Authors and Affiliations

  1. Department of Pathology, Renji Hospital Chongming Branch, Shanghai Jiaotong University, Shanghai, 202150, China

    Chen Feng  (陈峰)

  2. Department of Pathology, Changhai Hospital, Shanghai, 200433, China

    Chen Wei-hong  (陈伟红), Zheng Jian-ming  (郑建明) & Huang Ling  (黄玲)

Authors
  1. Chen Feng  (陈峰)
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  2. Chen Wei-hong  (陈伟红)
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  3. Zheng Jian-ming  (郑建明)
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  4. Huang Ling  (黄玲)
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Corresponding author

Correspondence to Chen Feng  (陈峰).

Additional information

Biography: CHEN Feng (1967–), male, attending pysician, Renji Hospital Chongming Branch, majors in pathology.

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Chen, F., Chen, Wh., Zheng, Jm. et al. Correlation between laminin and cathespin D expressions in breast carcinoma. Chin. J. Cancer Res. 18, 261–264 (2006). https://doi.org/10.1007/s11670-006-0261-0

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  • DOI: https://doi.org/10.1007/s11670-006-0261-0

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