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Proapoptotic function of FHIT gene

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  • Published:
Chinese Journal of Cancer Research

Abstract

Tumor suppressor gene plays an important role in maintaining the homeostasis between cell loss and growth. Fragile histidine triad (FHIT) gene found recently was studied in a deep going way; it becomes the focus as a result of its role of anti-tumor in human various type of tissue. Due to the high efficiency of FHIT gene benefiting the anti-tumor, it is proposed as a candidate of tumor suppressor gene though there are several opposite opinions.

We stress the summary of some properties of FHIT gene on proapoptosis according to the published data which showed the stronger proapoptotic function of FHIT gene; the apoptosis induced by FHIT depends on the expression level and status of FHIT; and FHIT gene can alternate the cell cycling properties and reduce the tumorigenic potential; the apoptotic process induced by FHIT has no relation to p53 gene. In a ward, in consideration of its multiple functions against malignancies, FHIT gene deserves attention and exploration as a selective target for searching the mechanism of tumorigenesis and clinical therapeutic applications in further.

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Authors and Affiliations

  1. Head and Neck Surgery Research Center, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, 100005, China

    Qiu Zhe-fu  (邱喆夫), Han De-min  (韩德民), Zhang Luo  (张罗) & Zhang Wei  (张伟)

Authors
  1. Qiu Zhe-fu  (邱喆夫)
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  2. Han De-min  (韩德民)
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  3. Zhang Luo  (张罗)
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  4. Zhang Wei  (张伟)
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Corresponding author

Correspondence to Qiu Zhe-fu  (邱喆夫).

Additional information

Biography: QIU Zhe-fu(1956–), male, doctor of medicine, attending physician, Head and Neck Surgery Research Center, Beijing Tongren Hospital, Capital University of Medical Sciences, majors in Surgical Oncology.

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Qiu, Zf., Han, Dm., Zhang, L. et al. Proapoptotic function of FHIT gene. Chin. J. Cancer Res. 18, 154–160 (2006). https://doi.org/10.1007/s11670-006-0154-2

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  • DOI: https://doi.org/10.1007/s11670-006-0154-2

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