Skip to main content
SpringerLink
Log in

Metachronous second primary cancers: Clinical analyses of 506 cases in a single institution

  • Articles
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective: To elucidate the clinical features and prognosis of multiple primary cancers, in order to make improvement of diagnosis and treatment. Methods: A total of 506 patients with two primary cancers admitted from 1973 to 2004 were analyzed retrospectively. Results: These cases accounted for 0.9% of all the hospitalized cases in the same period among which 126 were males, with the ratio of male to female 1:3. The median age at the onset of the first disease was 48 y (ranged from 24 to 77). The interval between the two cancers was longer in patients under 50 y and in males, but without statistical significance. The onset age of the two primary cancers was mainly centered around 40 to 60 y, while 70% of the second cancer occurred within 80 m after the first cancer but half of them occurred within five years. The interval between the two cancers played crucial role in affecting the prognosis (P<0.005). Conclusion: Fewer lethal cancers are involved in either the primary or the secondary malignancies. The interval between the two primaries contributes most to the prognoses.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Schoenberg BS, Greenberg RA, Eisenberg H. Occurrence of certain multiple primary cancers in females [J]. J Natl Cancer Inst 1969; 43:15–32.

    PubMed  CAS  Google Scholar 

  2. Schoenberg BS. Multiple primary malignant neoplasms. The Connecticut experience, 1935–1964 [J]. Recent Results Cancer Res 1977; 58:1–173.

    PubMed  CAS  Google Scholar 

  3. Warren S, Gates O. Multiple primary malignant tumors. A survey of the literature and a statistical study [J]. Am J Cancer 1932; 16:1358–414.

    Google Scholar 

  4. Chaudary MA, Millis RR, Hoskins EO, et al. Bilateral primary breast cancer: a prospective study of disease incidence [J]. Br J Surg 1984; 71:711–4.

    Article  PubMed  CAS  Google Scholar 

  5. Lee TK, Barringer M, Myers RT, et al. Multiple primary carcinomas of the colon and associated extracolonic primary malignant tumors [J]. Ann Surg 1982; 195:501–7.

    Article  PubMed  CAS  Google Scholar 

  6. Schenker JG, Levinsky R, Ohel G. Multiple primary malignant neoplasms in breast cancer patients in Israel [J]. Cancer 1984; 54:145–50.

    Article  PubMed  CAS  Google Scholar 

  7. Hemminki K, Jiang Y. Second primary neoplasms after 19281 endocrine gland tumors: aetiological links? Eur J Cancer 2001; 37:1886–94.

    Article  PubMed  CAS  Google Scholar 

  8. Bhatia S, Robinson LL, Oberlin O, et al. Breast cancer and other second neoplasms after childhood Hodgkin’s disease [J]. N Engl J Med 1996; 334:745–51.

    Article  PubMed  CAS  Google Scholar 

  9. Neugut AI, Murray T, Santos J, et al. Increased risk of lung cancer after breast cancer radiation therapy in cigarette smokers [J]. Cancer 1994; 73:1615–20.

    Article  PubMed  CAS  Google Scholar 

  10. Wynder EL, Mushinski MH, Spivak JC. Tobacco and alcohol consumption in relation to the development of multiple primary cancers [J]. Cancer 1977; 40:1872–8.

    Article  PubMed  CAS  Google Scholar 

  11. Schwartz LH, Ozsahin M, Zhang GN, et al. Synchronous and metachronous head and neck carcinomas [J]. Cancer 1994; 74:1933–8.

    Article  PubMed  CAS  Google Scholar 

  12. Van-Halteren HK, Taal BG, van-Tinteren H, et al. Risk factors for the development ofoesophageal cancer as a second primary tumor [J]. Eur J Cancer 1995; 31(A):1836–9.

    Article  Google Scholar 

  13. Engeland A, Bjorge T, Haldorsen T, et al. Use of multiple primary cancers to indicate associations between smoking and cancer incidence: an analysis of 500,000 cancer cases diagnosed in Norway during 1953–93 [L]. Int J Cancer 1997; 7:401–7.

    Article  Google Scholar 

  14. Li FP, Fraumeni JF Jr. Prospective study of a family cancer syndrome [J]. JAMA 1982; 247:2692–4.

    Article  PubMed  CAS  Google Scholar 

  15. Wooster R, Neuhausen SL, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12–13 [J]. Science 1994; 265:2088–90.

    Article  PubMed  CAS  Google Scholar 

  16. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 [J]. Science 1994; 266:66–71.

    Article  PubMed  CAS  Google Scholar 

  17. Varley JM, Evans DG, Birch JM. Li-Fraumeni syndrome—a molecular and clinical review [J]. Br J Cancer 1997; 76:1–14.

    PubMed  CAS  Google Scholar 

  18. Cianciulli AM, Venture I, Leonado F. Mutagen sensitive and cancer susceptibility in patients with multiple primary cancers [J]. Oncol REP 1995; 2:1021–26.

    Google Scholar 

  19. Teppo L, Pukkala E, Saxen E. Multiple cancer—an epidemiologic exercise in Finland [J]. J Natl Cancer Inst 1985; 75:207–17.

    PubMed  CAS  Google Scholar 

  20. Prior P, Waterhouse JA. Multiple primary cancers of the breast and ovary [J]. Br J Cancer 1981; 44:628–36.

    PubMed  CAS  Google Scholar 

  21. Gulay H, Hamaloglu E, Bulut O, et al. Bilateral breast carcinoma: 28 years’ experience [J]. World J Surg 1990; 14:529–33.

    Article  PubMed  CAS  Google Scholar 

  22. Enblad P, Adami HO, Glimelius B, et al. The risk of subsequent primary malignant diseases after cancers of the colon and rectum. A nationwide cohort study [J]. Cancer 1990; 65:2091–100.

    Article  PubMed  CAS  Google Scholar 

  23. Santos MC, Gardner B, Feldman J. Analysis of multiple primary cancers in a single institution [J]. J Surg Oncol 1994; 55:95–9.

    Article  PubMed  CAS  Google Scholar 

  24. Liu FS, Qin DX, Wang QL. A clinico-pathological analysis of 172 patients with multiple primary malignant tumors (MPMT) [J]. Chin J Oncol 1979; 1:113–9.

    CAS  Google Scholar 

  25. Crocetti E, Buiattib E, Falini P. Multiple primary cancer incidence in Italy [J]. Eur J Cancer 2001; 37:2449–56.

    Article  PubMed  CAS  Google Scholar 

  26. Aydiner A, Karadeniz A, Uygun K, et al. Multiple primary neoplasms at a single institution: differences between synchronous and metachronous neoplasms [J]. Am J Clin Oncol 2000; 23:364–70.

    Article  PubMed  CAS  Google Scholar 

  27. Ikeguchi M, Ohfuji S, Oka A. Synchronous and metachronous primary malignancies in organs other than the stomach in patients with early gastric cancer [J]. Hepatogastoenterology 1995; 42:672–6.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgical Oncology, Beijing Cancer Hospital, Peking University School of Oncology, 100036, Beijing

    Su Xiang-qian, Hao Chun-yi & Gao Fei

Authors
  1. Su Xiang-qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hao Chun-yi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gao Fei
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Su Xiang-qian.

Additional information

Biography: SU Xiang-qian (1962–), male, doctor of medicine, associate professor, Peking University School of Oncology, majors in surgical oncology.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Su, Xq., Hao, Cy. & Gao, F. Metachronous second primary cancers: Clinical analyses of 506 cases in a single institution. Chin. J. Cancer Res. 17, 57–62 (2005). https://doi.org/10.1007/s11670-005-0012-7

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11670-005-0012-7

Key words

CLC number

Search

Navigation